Working with us means joining a research institute within the University of Bonn that is dedicated to the promotion of talented young researchers. It means the opportunity to conduct cutting-edge research in a multidisciplinary, resource-rich environment where people come together to collaborate, share ideas and inspire each other's research aspirations.
Open PhD position to study membrane-mediated protein self-assembly
The group of Protein Design and Self-Assembly at the Life and Medical Sciences Institute, University of Bonn is offering a PhD position (TV-L EG 13 50%) to study membrane-mediated protein self-assembly.
The Khmelinskaia lab has a novel hybrid approach to study protein self-assembly: we combine de novo computational protein design and in vitro biophysical characterization to dissect the physical principles behind this ubiquitous phenomenon. In this project, we aim to understand the fine balance between protein-protein and protein-membrane interactions, protein structural flexibility and membrane elasticity that allow for the formation of curvature inducing protein coats, involved in a number of important biological processes such as viral envelopment and endocytic signaling pathways. De novo designed proteins can not only recapitulate the self-assembling behavior of natural systems but are also more resilient to modification then their natural counterparts, while in vitro model systems allow us to investigate the process in a controlled environment. We use computational tools, such as Rosetta based protein design and structural predictions, to create protein scaffolds with precise properties and characterize their assembly pathways in vitro using structural biophysical methods, model lipid membranes and microcopy techniques. We aim to capture the behavior of naturally occurring systems and further map out the possible assembly space.
- Enthusiasm for research in a collaborative environment
- Strong interest in solving fundamental biological problems
- Experience in molecular biology, protein biochemistry, physics, biophysics and/or computational biology (Master’s degree or equivalent)
- Excellent degrees and track record
- Very good communication skills (English)
- Challenging projects at the interface of biophysics, molecular biology and computational biology
- A stimulating, multidisciplinary and international research environment
- Supportive mentoring
- Salary will be according to the German salary scale TV-L EG 13
- A “Jobticket” (subsidized public transport) is available
- There is also a possibility to use the day care center
- Supplementary benefits in the public sector (pension plan according to VBL)
- numerous offers of university sports
We welcome people from all backgrounds to join our lab! To apply, please send your CV, short motivation letter and contact information of 2 scientific referees to Alena Khmelinskaia via e-mail (email@example.com).
Position vacancies for non-academic staff will be advertised on this page and that of the University of Bonn.
For people interested in studying with us, please visit our Education and Training page for more details on study courses and application information.
People holding fellowships at any career level, are strongly encouraged to apply directly to the lab head of a specific research group of interest at any time. Information regarding German Research Funding opportunities can be found below.
International staff and students are also encouraged to visit our International LIMES page for more helpful links and information about life at the LIMES institute.
There are many funding streams supporting scientists transitioning from different labs, countries and career levels. Ranging from organizations such as the German Academic Exchange Service (DAAD), EMBO, and foundations such as the Alexander von Humboldt Foundation, to programs including the Human Frontiers Science Program, you will find something suitable for you.
To help kick-start start your research, the Research in Germany website provides comprehensive information about the German research funding system, funding organizations and funding programs for international researchers at all career levels.
In addition, the Human Resource Development team at the University of Bonn offers both researchers and technical and administrative staff members a wide range of consultation offers and seminars.
The city of Bonn, on the river Rhine with a population of 320,000 is a vibrant, multicultural university town and ideal location for our institute. The university district is dominated by the ‘Bonner’ youth and numerous cafés, restaurants and bars add to the lively atmosphere in the inner city. Bonn is the birthplace of Ludwig van Beethoven, who lived here for over 20 years before his life took him to Vienna. It is a cultural center that hosts prestigious concerts and exhibitions, attracting over 1 million visitors from around the world to its Museum Mile each year.
The city is also home to 18 United Nations organizations and several world-class research and education institutions. The international University of Bonn (German: Rheinische Friedrich-Wilhelms-Universität Bonn) was founded in its present form in 1818, by King Frederick William III of Prussia and is now one of Germany's most reputable institutions of higher learning with over 30,000 students. Among its most famous alumni are seven Nobel Prize winners, fourteen laureates of the Gottfried Wilhelm Leibniz Prize, two winners of the Fields Medal, Pope Benedict XVI, Heinrich Heine, Karl Marx, Konrad Adenauer, Joseph Schumpeter and Friedrich Nietzsche. It is also one of the German universities, which was included as part of the Excellence Initiative in the funding lines the Cluster of Excellence and Graduate Schools.