We aim to employ DNA- and RNA nanotechnology to develop mRNA packaging and unpackaging systems for targeted delivery to specific cells or tissues. Objectives include enhancing the stability of mRNA within nanoparticles, minimizing immunogenicity, and maximizing delivery efficiency. Through a combination of computational modeling, molecular biology techniques, and in vitro experimentation, the project seeks to create a versatile platform that can be tailored for various therapeutic applications.

DNA- and RNA nanostructures have the potential of being used as a means to construct molecular logic gates by leveraging the programmability and versatility of DNA. Potential applications range from biocomputing and nanotechnology to synthetic biology. This project seeks to contribute to the advancement of molecular computing and its integration into various scientific fields.

Aptamers are single-stranded oligonucleotides that bind specific targets with high affinity. They are produced through SELEX, a process where a library of random sequences undergoes iterative selection rounds to enrich the highest-affinity binders. Our goal is to develop selection methods that facilitate the selection of aptamers based on their functional properties rather than on their binding capabilities.