The Femmunity Study
The Femmunity Study , led by Dr. Tal Pecht (LIMES institute, UKB & DZNE) and Jun. Prof. Marie-Christine Simon (University of Bonn), is a multidisciplinary research initiative exploring how menstrual cycles and hormonal contraceptives influence immune function, metabolism, and gut microbiome dynamics. The study seeks to advance our understanding of female physiology and identify potential biomarkers of menstrual and immune health.
Research Aims
- Characterize immune system dynamics across the menstrual cycle:
Investigate how natural hormonal fluctuations influence immune activity in healthy women. - Assess the effects of oral contraceptives on immunity and metabolism:
Determine whether hormonal contraceptives alter immune function, metabolic parameters, or gut microbiome composition. - Explore menstrual fluid as a biomarker of endometrial and immune health:
Analyze menstrual fluid to identify immune and molecular signals that reflect reproductive and systemic health. - Examine interactions between hormones, metabolism, and gut microbiome:
Understand how cyclical hormonal changes affect metabolic pathways and gut microbiota composition.
Participant Eligibility
We are seeking participants who:
- Are 20–30 years old
- Are non-smokers
- Have no chronic diseases
Project-Specific Criteria:
- Project 1 – Natural Cycle: Regular menstrual cycles, not using hormonal contraceptives or intra-uterine device (IUD)
- Project 2 – Oral Contraceptives: Currently using birth control pills
- Project 3 – Menstrual Fluid: Conveniently providing menstrual fluid samples
How does the study work?
We have several interconnected studies running, and we invite you to take part! Join us to contribute to groundbreaking research and gain insights into your own health.
MHOON Project
Menstruation, HOrmones, Ovulation & immuNity
Over a period of 5–6 weeks, you will have 5 morning appointments, each lasting about one hour.
During the study, you’ll keep a cycle diary and document your lifestyle habits at home.
You will wear two small sensors: one that continuously measures your body temperature, and another that continuously measures your blood sugar.
At each appointment, we will check your health status, measure your body composition, and take blood samples to evaluate your immune and metabolic state.
MHOON-Pill-Project
Menstruation, hormonal contraceptives, ovulation, and immunity
You’ll have 4 morning appointments: 2 while you are on the pill and 2 while you are off the pill.
During the study, you’ll keep a short daily diary and record your lifestyle habits at home.
You will wear two small sensors: one that continuously measures your body temperature and another that continuously measures your blood sugar.
At each appointment, we will check your health status, measure your body composition, and take blood samples to learn more about your immune and metabolic balance.
ENDOSCOP Project
ENDOmetrium Einzelzell-Omics-Profiling
Menstrual blood contains cells, hormones, proteins, and immune factors that are important for understanding human health, but it has been little studied so far.
We aim to investigate the immunological characteristics of menstrual blood in healthy participants to gain valuable insights into health and immunity.
We ask you to collect your menstrual blood on the 2nd day of your period for about 8 hours using a menstrual cup, which will be provided.
Participants in the study will receive compensation for their participation.
How to Participate
By participating, you will contribute to advancing knowledge of menstrual and immune health in women.
Complete the Femmunity Study Survey →
For inquiries, contact the study team at femmunity@dzne.de