Publications

2021

Frishberg A, Kooistra E, Nuesch-Germano M, Pecht T, Milman N, Reusch N, Warnat-Herresthal S, Bruse N, Händler K, Theis H, Kraut M, van Rijssen E, van Cranenbroek B, Koenen HJ, Heesakkers H, van den Boogaard M, Zegers M, Pickkers P, Becker M, Aschenbrenner AC, Ulas T, Theis FJ, Shen-Orr SS, Schultze JL, Kox M. Mature neutrophils and a NF-κB-to-IFN transition determine the unifying disease recovery dynamics in COVID-19. Cell Rep Med. 2022 May 17:100652.

Li Q, Wang Y, Sun Q, Knopf J, Herrmann M, Lin L, Jiang J, Shao C, Li P, He X, Hua F, Niu Z, Ma C, Zhu Y, Ippolito G, Piacentini M, Estaquier J, Melino S, Weiss FD, Andreano E, Latz E, Schultze JL, Rappuoli R, Mantovani A, Mak TW, Melino G & Shi Y. Immune response in COVID-19: what is next? Cell Death Differ. 2022 May 17:1–16.

Jackson J, Wischhof L, Scifo E, Pellizzer A, Wang Y, Piazzesi A, Gentile D, Siddig S, Stork M, Hopkins CE, Händler K, Weis J, Roos A, Schultze JL, Nicotera P, Ehninger D & Bano D. SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells. Mol Metab. 2022 Apr 19;61:101503

Duy PQ, Weise SC, Marini C, Li XJ, Liang D, Dahl PJ, Ma S, Spajic A, Dong W, Juusola J, Kiziltug E, Kundishora AJ, Koundal S, Pedram MZ, Torres-Fernández LA, Händler K, De Domenico E, Becker M, Ulas T, Juranek SA, Cuevas E, Hao LT, Jux B, Sousa AMM, Liu F, Kim SK, Li M, Yang Y, Takeo Y, Duque A, Nelson-Williams C, Ha Y, Selvaganesan K, Robert SM, Singh AK, Allington G, Furey CG, Timberlake AT, Reeves BC, Smith H, Dunbar A, DeSpenza T Jr, Goto J, Marlier A, Moreno-De-Luca A, Yu X, Butler WE, Carter BS, Lake EMR, Constable RT, Rakic P, Lin H, Deniz E, Benveniste H, Malvankar NS, Estrada-Veras JI, Walsh CA, Alper SL, Schultze JL, Paeschke K, Doetzlhofer A, Wulczyn FG, Jin SC, Lifton RP, Sestan N, Kolanus W, Kahle KT. Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus. Nat Neurosci. 2022 Apr;25(4):458-473.

Schultze JL, Gabriel M, Nicotera P. Time for a voluntary crisis research service. Cell Death Differ. 2022 Apr;29(4):888-890.

Piazzesi A, Wang Y, Jackson J, Wischhof L, Zeisler-Diehl V, Scifo E, Oganezova I, Hoffmann T, Gómez Martín P, Bertan F, Wrobel CJJ, Schroeder FC, Ehninger D, Händler K, Schultze JL, Schreiber L, van Echten-Deckert G, Nicotera P & Bano D. CEST-2.2 overexpression alters lipid metabolism and extends longevity of mitochondrial mutants. EMBO Rep. 2022 May 4;23(5):e52606.

Günes Günsel G, Conlon TM, Jeridi A, Kim R, Ertüz Z, Lang NJ, Ansari M, Novikova M, Jiang D, Strunz M, Gaianova M, Hollauer C, Gabriel C, Angelidis I, Doll S, Pestoni JC, Edelmann SL, Kohlhepp MS, Guillot A, Bassler K, Van Eeckhoutte HP, Kayalar Ö, Konyalilar N, Kanashova T, Rodius S, Ballester-López C, Genes Robles CM, Smirnova N, Rehberg M, Agarwal C, Krikki I, Piavaux B, Verleden SE, Vanaudenaerde B, Königshoff M, Dittmar G, Bracke KR, Schultze JL, Watz H, Eickelberg O, Stoeger T, Burgstaller G, Tacke F, Heissmeyer V, Rinkevich Y, Bayram H, Schiller HB, Conrad M, Schneider R, Yildirim AÖ. The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD. Nat Commun. 2022 Mar 14;13(1):1303

Schimke LF, Marques AHC, Baiocchi GC, de Souza Prado CA, Fonseca DLM, Freire PP, Rodrigues Plaça D, Salerno Filgueiras I, Coelho Salgado R, Jansen-Marques G, Rocha Oliveira AE, Peron JPS, Cabral-Miranda G, Barbuto JAM, Camara NOS, Calich VLG, Ochs HD, Condino-Neto A, Overmyer KA, Coon JJ, Balnis J, Jaitovich A, Schulte-Schrepping J, Ulas T, Schultze JL, Nakaya HI, Jurisica I, Cabral-Marques O. Severe COVID-19 Shares a Common Neutrophil Activation Signature with Other Acute Inflammatory States. Cells. 2022 Mar 1;11(5):847

Temba GS, Vadaq N, Wan J, Kullaya V, Huskens D, Pecht T, Jaeger M, Boahen CK, Matzaraki V, Broeders W, Joosten LAB, Faradz SMH, Kibiki G, Middeldorp S, Cavalieri D, Lionetti P, de Groot PG, Schultze JL, Netea MG, Kumar V, de Laat B, Mmbaga BT, van der Ven AJ, Roest M & de Mast Q. Differences in thrombin and plasmin generation potential between East African and Western European adults: The role of genetic and non-genetic factors. J Thromb Haemost. 2022 Feb 1.

Georg P, Astaburuaga-García R, Bonaguro L, Brumhard S, Michalick L, Lippert LJ, Kostevc T, Gäbel C, Schneider M, Streitz M, Demichev V, Gemünd I, Barone M, Tober-Lau P, Helbig ET, Hillus D, Petrov L, Stein J, Dey HP, Paclik D, Iwert C, Mülleder M, Aulakh SK, Djudjaj S, Bülow RD, Mei HE, Schulz AR, Thiel A, Hippenstiel S, Saliba AE, Eils R, Lehmann I, Mall MA, Stricker S, Röhmel J, Corman VM, Beule D, Wyler E, Landthaler M, Obermayer B, von Stillfried S, Boor P, Demir M, Wesselmann H, Suttorp N, Uhrig A, Müller-Redetzky H, Nattermann J, Kuebler WM, Meisel C, Ralser M, Schultze JL, Aschenbrenner AC, Thibeault C, Kurth F, Sander LE, Blüthgen N, Sawitzki B & PA-COVID-19 Study Group. Complement activation induces excessive T cell cytotoxicity in severe COVID-19.Cell. 2022 Feb 3;185(3):493-512.e25.

2021

Langkabel J, Horne A, Bonaguro L, Holsten L, Hesse T, Knaus A, Riedel Y, Becker M, Händler K, Elmzzahi T, Bassler K, Reusch N, Yeghiazarian LH, Pecht T, Saglam A, Ulas T, Aschenbrenner AC, Kaiser F, Kubaczka C, Schultze JL, & Schorle H. Induction of Rosette-to-Lumen stage embryoids using reprogramming paradigms in ESCsNat Commun. 2021 Dec 16;12(1):7322.

Wendisch D, Dietrich O, Mari T, von Stillfried S, Ibarra IL, Mittermaier M, Mache C, Chua RL, Knoll R, Timm S, Brumhard S, Krammer T, Zauber H, Hiller AL, Pascual-Reguant A, Mothes R, Bülow RD, Schulze J, Leipold AM, Djudjaj S, Erhard F, Geffers R, Pott F, Kazmierski J, Radke J, Pergantis P, Baßler K, Conrad C, Aschenbrenner AC, Sawitzki B, Landthaler M, Wyler E, Horst D; Deutsche COVID-19 OMICS Initiative (DeCOI), Hippenstiel S, Hocke A, Heppner FL, Uhrig A, Garcia C, Machleidt F, Herold S, Elezkurtaj S, Thibeault C, Witzenrath M, Cochain C, Suttorp N, Drosten C, Goffinet C, Kurth F, Schultze JL, Radbruch H, Ochs M, Eils R, Müller-Redetzky H, Hauser AE, Luecken MD, Theis FJ, Conrad C, Wolff T, Boor P, Selbach M, Saliba AE, & Sander LE. SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis. Cell. 2021 Dec 22;184(26):6243-6261.e27.

Gerber JP, Russ J, Chandrasekar V, Offermann N, Lee HM, Spear S, Guzzi N, Maida S, Pattabiraman S, Zhang R, Kayvanjoo AH, Datta P, Kasturiarachchi J, Sposito T, Izotova N, Händler K, Adams PD, Marafioti T, Enver T, Wenzel J, Beyer M, Mass E, Bellodi C, Schultze JL, Capasso M, Nimmo R & Salomoni P. Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation. Nat Cell Biol. 2021 Dec 7. doi: 10.1038/s41556-021-00774-y.

Kummer MP, Ising C, Kummer C, Sarlus H, Griep A, Vieira-Saecker A, Schwartz S, Halle A, Brückner M, Händler K, Schultze JL, Beyer M, Latz E & Heneka MT. Microglial PD-1 stimulation by astrocytic PD-L1 suppresses neuroinflammation and Alzheimer's disease pathology. EMBO J. 2021 Nov 26:e108662. doi: 10.15252/embj.2021108662.

Willenborg S, Sanin DE, Jais A, Ding X, Ulas T, Nüchel J, Popović M, MacVicar T, Langer T, Schultze JL, Gerbaulet A, Roers A, Pearce EJ, Brüning JC, Trifunovic A & Eming SA. Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing. Cell Metab. 2021 Dec 7;33(12):2398-2414.e9. doi: 10.1016/j.cmet.2021.10.004.

Katzmarski N, Domínguez-Andrés J, Cirovic B, Renieris G, Ciarlo E, Le Roy D, Lepikhov K, Kattler K, Gasparoni G, Händler K, Theis H, Beyer M, van der Meer JWM, Joosten LAB, Walter J, Schultze JL, Roger T, Giamarellos-Bourboulis EJ, Schlitzer A & Netea MG. Transmission of trained immunity and heterologous resistance to infections across generations. Nat Immunol. 2021 Nov;22(11):1382-1390. doi: 10.1038/s41590-021-01052-7.

Krämer B, Knoll R, Bonaguro L, ToVinh M, Raabe J, Astaburuaga-García R, Schulte-Schrepping J, Kaiser KM, Rieke GJ, Bischoff J, Monin MB, Hoffmeister C, Schlabe S, De Domenico E, Reusch N, Händler K, Reynolds G, Blüthgen N, Hack G, Finnemann C, Nischalke HD, Strassburg CP, Stephenson E, Su Y, Gardner L, Yuan D, Chen D, Goldman J, Rosenstiel P, Schmidt SV, Latz E, Hrusovsky K, Ball AJ, Johnson JM, Koenig PA, Schmidt FI, Haniffa M, Heath JR, Kümmerer BM, Keitel V, Jensen B, Stubbemann P, Kurth F, Sander LE, Sawitzki B; Deutsche COVID-19 OMICS Initiative (DeCOI), Aschenbrenner AC, Schultze JL & Nattermann J. Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19. Immunity. 2021 Nov 9;54(11):2650-2669.e14. doi: 10.1016/j.immuni.2021.09.002.

Kern P, Balzer NR, Blank N, Cygon C, Wunderling K, Bender F, Frolov A, Sowa JP, Bonaguro L, Ulas T, Homrich M, Kiermaier E, Thiele C, Schultze JL, Canbay A, Bauer R & Mass E. Creld2 function during unfolded protein response is essential for liver metabolism homeostasis. FASEB J. 2021 Oct;35(10):e21939. doi: 10.1096/fj.202002713RR.

Fujii W, Kapellos TS, Baßler K, Händler K, Holsten L, Knoll R, Warnat-Herresthal S, Oestreich M, Hinkley ER, Hasenauer J, Pizarro C, Thiele C, Aschenbrenner AC, Ulas T, Skowasch D & Schultze JL.Alveolar macrophage transcriptomic profiling in COPD shows major lipid metabolism changes. ERJ Open Res. 2021 Sep 13;7(3):00915-2020. doi: 10.1183/23120541.00915-2020.

Oestreich M, Chen D, Schultze JL, Fritz M & Becker M.Privacy considerations for sharing genomics data. EXCLI J. 2021 Jul 16;20:1243-1260. doi: 10.17179/excli2021-4002.

Zocher S, Overall RW, Berdugo-Vega G, Rund N, Karasinsky A, Adusumilli VS, Steinhauer C, Scheibenstock S, Händler K, Schultze JL, Calegari F & Kempermann G. De novo DNA methylation controls neuronal maturation during adult hippocampal neurogenesis. EMBO J. 2021 Sep 15;40(18):e107100. doi: 10.15252/embj.2020107100.

Knoll R., Schultze JL. & Schulte-Schrepping J.Monocytes and Macrophages in COVID-19. Frontiers in Immunology. 2021 ;12:2952. doi: 10.3389/fimmu.2021.720109.

Embgenbroich M, van der Zande HJP, Hussaarts L, Schulte-Schrepping J, Pelgrom LR, García-Tardón N, Schlautmann L, Stoetzel I, Händler K, Lambooij JM, Zawistowska-Deniziak A, Hoving L, de Ruiter K, Wijngaarden M, Pijl H, Willems van Dijk K, Everts B, van Harmelen V, Yazdanbakhsh M, Schultze JL, Guigas B, Burgdorf S. Soluble mannose receptor induces proinflammatory macrophage activation and metaflammation. Proc Natl Acad Sci U S A. 2021 Aug 3;118(31):e2103304118. doi: 10.1073/pnas.2103304118. PMID: 34326259

Bui LT, Winters NI, Chung MI, Joseph C, Gutierrez AJ, Habermann AC, Adams TS, Schupp JC, Poli S, Peter LM, Taylor CJ, Blackburn JB, Richmond BW, Nicholson AG, Rassl D, Wallace WA, Rosas IO, Jenkins RG, Kaminski N, Kropski JA, Banovich NE & Human Cell Atlas Lung Biological Network. Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity. Nat Commun. 2021 Jul 14;12(1):4314. doi: 10.1038/s41467-021-24467-0. PMID: 34262047

Warnat-Herresthal S, Schultze H, Shastry KL, Manamohan S, Mukherjee S, Garg V, Sarveswara R, Händler K, Pickkers P, Aziz NA, Ktena S, Tran F, Bitzer M, Ossowski S, Casadei N, Herr C, Petersheim D, Behrends U, Kern F, Fehlmann T, Schommers P, Lehmann C, Augustin M, Rybniker J, Altmüller J, Mishra N, Bernardes JP, Krämer B, Bonaguro L, Schulte-Schrepping J, De Domenico E, Siever C, Kraut M, Desai M, Monnet B, Saridaki M, Siegel CM, Drews A, Nuesch-Germano M, Theis H, Heyckendorf J, Schreiber S, Kim-Hellmuth S; COVID-19 Aachen Study (COVAS), Nattermann J, Skowasch D, Kurth I, Keller A, Bals R, Nürnberg P, Rieß O, Rosenstiel P, Netea MG, Theis F, Mukherjee S, Backes M, Aschenbrenner AC, Ulas T; Deutsche COVID-19 Omics Initiative (DeCOI), Breteler MMB, Giamarellos-Bourboulis EJ, Kox M, Becker M, Cheran S, Woodacre MS, Goh EL & Schultze JL. Swarm Learning for decentralized and confidential clinical machine learning. Nature. 2021 Jun;594(7862):265-270. doi: 10.1038/s41586-021-03583-3. Epub 2021 May 26. PMID: 34040261

Torres Fernández LA, Mitschka S, Ulas T, Weise S, Dahm K, Becker M, Händler K, Beyer M, Windhausen J, Schultze JL & Kolanus W. The stem cell-specific protein TRIM71 inhibits maturation and activity of the pro-differentiation miRNA let-7 via two independent molecular mechanisms. RNA. 2021 May 11;27(7):805–28. doi: 10.1261/rna.078696.121. PMID: 33975917; PMCID: PMC8208056.

Reusch N, De Domenico E, Bonaguro L, Schulte-Schrepping J, Baßler K, Schultze JL & Aschenbrenner AC.Neutrophils in COVID-19. Front Immunol. 2021 Mar 25;12:652470. doi: 10.3389/fimmu.2021.652470. PMID: 33841435

Schultze JL & Aschenbrenner AC.COVID-19 and the human innate immune system. Cell. 2021 Apr 1;184(7):1671-1692. doi: 10.1016/j.cell.2021.02.029. Epub 2021 Feb 16. PMID: 33743212

Muus C, Luecken MD, Eraslan G, Sikkema L, Waghray A, Heimberg G, Kobayashi Y, Vaishnav ED, Subramanian A, Smillie C, Jagadeesh KA, Duong ET, Fiskin E, Triglia ET, Ansari M, Cai P, Lin B, Buchanan J, Chen S, Shu J, Haber AL, Chung H, Montoro DT, Adams T, Aliee H, Allon SJ, Andrusivova Z, Angelidis I, Ashenberg O, Bassler K, Bécavin C, Benhar I, Bergenstråhle J, Bergenstråhle L, Bolt L, Braun E, Bui LT, Callori S, Chaffin M, Chichelnitskiy E, Chiou J, Conlon TM, Cuoco MS, Cuomo ASE, Deprez M, Duclos G, Fine D, Fischer DS, Ghazanfar S, Gillich A, Giotti B, Gould J, Guo M, Gutierrez AJ, Habermann AC, Harvey T, He P, Hou X, Hu L, Hu Y, Jaiswal A, Ji L, Jiang P, Kapellos TS, Kuo CS, Larsson L, Leney-Greene MA, Lim K, Litviňuková M, Ludwig LS, Lukassen S, Luo W, Maatz H, Madissoon E, Mamanova L, Manakongtreecheep K, Leroy S, Mayr CH, Mbano IM, McAdams AM, Nabhan AN, Nyquist SK, Penland L, Poirion OB, Poli S, Qi C, Queen R, Reichart D, Rosas I, Schupp JC, Shea CV, Shi X, Sinha R, Sit RV, Slowikowski K, Slyper M, Smith NP, Sountoulidis A, Strunz M, Sullivan TB, Sun D, Talavera-López C, Tan P, Tantivit J, Travaglini KJ, Tucker NR, Vernon KA, Wadsworth MH, Waldman J, Wang X, Xu K, Yan W, Zhao W, Ziegler CGK; NHLBI LungMap Consortium; Human Cell Atlas Lung Biological Network. Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics. Nat Med. 2021 Mar;27(3):546-559. doi: 10.1038/s41591-020-01227-z. Epub 2021 Mar 2. PMID: 33654293.

Temba GS, Kullaya V, Pecht T, Mmbaga BT, Aschenbrenner AC, Ulas T, Kibiki G, Lyamuya F, Boahen CK, Kumar V, Joosten LAB, Schultze JL, van der Ven AJ, Netea MG & de Mast Q. Urban living in healthy Tanzanians is associated with an inflammatory status driven by dietary and metabolic changes. Nat Immunol. 2021 Mar;22(3):287-300. doi: 10.1038/s41590-021-00867-8. Epub 2021 Feb 11. PMID: 33574617.

Enderes J, Mallesh S, Schneider R, Hupa KJ, Lysson M, Schneiker B, Händler K, Schlotmann B, Günther P, Schultze JL, Kalff JC & Wehner S. A Population of Radio-Resistant Macrophages in the Deep Myenteric Plexus Contributes to Postoperative Ileus Via Toll-Like Receptor 3 Signaling. Front Immunol. 2021 Jan 13;11:581111. doi: 10.3389/fimmu.2020.581111. PMID: 33519804

Aschenbrenner AC, Mouktaroudi M, Krämer B, Oestreich M, Antonakos N, Nuesch-Germano M, Gkizeli K, Bonaguro L, Reusch N, Baßler K, Saridaki M, Knoll R, Pecht T, Kapellos TS, Doulou S, Kröger C, Herbert M, Holsten L, Horne A, Gemünd ID, Rovina N, Agrawal S, Dahm K, van Uelft M, Drews A, Lenkeit L, Bruse N, Gerretsen J, Gierlich J, Becker M, Händler K, Kraut M, Theis H, Mengiste S, De Domenico E, Schulte-Schrepping J, Seep L, Raabe J, Hoffmeister C, ToVinh M, Keitel V, Rieke G, Talevi V, Skowasch D, Aziz NA, Pickkers P, van de Veerdonk FL, Netea MG, Schultze JL, Kox M, Breteler MMB, Nattermann J, Koutsoukou A, Giamarellos-Bourboulis EJ & Ulas T; German COVID-19 Omics Initiative (DeCOI). Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients. Genome Med. 2021 Jan 13;13(1):7. doi: 10.1186/s13073-020-00823-5. PMID: 33441124.

Wang M, Yang Y, Cansever D, Wang Y, Kantores C, Messiaen S, Moison D, Livera G, Chakarov S, Weinberger T, Stremmel C, Fijak M, Klein B, Pleuger C, Lian Z, Ma W, Liu Q, Klee K, Händler K, Ulas T, Schlitzer A, Schultze JL, Becher B, Greter M, Liu Z, Ginhoux F, Epelman S, Schulz C, Meinhardt A & Bhushan S. Two populations of self-maintaining monocyte-independent macrophages exist in adult epididymis and testis. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2013686117. doi: 10.1073/pnas.2013686117. PMID: 33372158.

2020

De Domenico E, Bonaguro L, Schulte-Schrepping J, Becker M, Händler K & Schultze JL. Optimized workflow for single-cell transcriptomics on infectious diseases including COVID-19. STAR Protoc. 2020 Dec 16;1(3):100233. doi: 10.1016/j.xpro.2020.100233. PMID: 33377120; PMCID: PMC7757730.

Bernardes JP, Mishra N, Tran F, Bahmer T, Best L, Blase JI, Bordoni D, Franzenburg J, Geisen U, Josephs-Spaulding J, Köhler P, Künstner A, Rosati E, Aschenbrenner AC, Bacher P, Baran N, Boysen T, Brandt B, Bruse N, Dörr J, Dräger A, Elke G, Ellinghaus D, Fischer J, Forster M, Franke A, Franzenburg S, Frey N, Friedrichs A, Fuß J, Glück A, Hamm J, Hinrichsen F, Hoeppner MP, Imm S, Junker R, Kaiser S, Kan YH, Knoll R, Lange C, Laue G, Lier C, Lindner M, Marinos G, Markewitz R, Nattermann J, Noth R, Pickkers P, Rabe KF, Renz A, Röcken C, Rupp J, Schaffarzyk A, Scheffold A, Schulte-Schrepping J, Schunk D, Skowasch D, Ulas T, Wandinger KP, Wittig M, Zimmermann J, Busch H, Hoyer BF, Kaleta C, Heyckendorf J, Kox M, Rybniker J, Schreiber S, Schultze JL & Rosenstiel P; HCA Lung Biological Network; Deutsche COVID-19 Omics Initiative (DeCOI). Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19. Immunity. 2020 Nov 26:S1074-7613(20)30504-5. doi: 10.1016/j.immuni.2020.11.017.

Divangahi M, Aaby P, Khader SA, Barreiro LB, Bekkering S, Chavakis T, van Crevel R, Curtis N, DiNardo AR, Dominguez-Andres J, Duivenwoorden R, Fanucchi S, Fayad Z, Fuchs E, Hamon M, Jeffrey KL, Khan N, Joosten LAB, Kaufmann E, Latz E, Matarese G, van der Meer JWM, Mhlanga M, Moorlag SJCFM, Mulder WJM, Naik S, Novakovic B, O'Neill L, Ochando J, Ozato K, Riksen NP, Sauerwein R, Sherwood ER, Schlitzer A, Schultze JL, Sieweke MH, Benn CS, Stunnenberg H, Sun J, van de Veerdonk FL, Weis S, Williams DL, Xavier R & Netea MG. Trained immunity, tolerance, priming and differentiation: distinct immunological processes. Nat Immunol. 2020 Dec 8. doi: 10.1038/s41590-020-00845-6.

Bonaguro, L., Köhne, M., Schmidleithner, L., Schulte-Schrepping, J., Warnat-Herresthal, S., Horne, A., Kern, P., Günther, P., ter Horst, R., Jaeger, M., Rahmouni, S., Georges, M., Falk, C. S., Li, Y., Mass, E., Beyer, M., Joosten, L. A. B., Netea, M. G., Ulas, T., Schultze, J. L. & Aschenbrenner, A. C.CRELD1 modulates homeostasis of the immune system in mice and humans. Nat. Immunol. (2020). doi:10.1038/s41590-020-00811-2

Kalafati L, Kourtzelis I, Schulte-Schrepping J, Li X, Hatzioannou A, Grinenko T, Hagag E, Sinha A, Has C, Dietz S, de Jesus Domingues AM, Nati M, Sormendi S, Neuwirth A, Chatzigeorgiou A, Ziogas A, Lesche M, Dahl A, Henry I, Subramanian P, Wielockx B, Murray P, Mirtschink P, Chung KJ, Schultze JL, Netea MG, Hajishengallis G, Verginis P, Mitroulis I & Chavakis T. Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity. Cell. 2020 Oct 29;183(3):771-785.e12. doi: 10.1016/j.cell.2020.09.058.

Becker M, Schultze H, Bresniker K, Singhal S, Ulas T & Schultze JL.A novel computational architecture for large-scale genomics. Nat Biotechnol. 2020 Sep 30. doi: 10.1038/s41587-020-0699-5.

Rabold K, Aschenbrenner A, Thiele C, Boahen CK, Schiltmans A, Smit JWA, Schultze JL, Netea MG, Adema GJ & Netea-Maier RT. Enhanced lipid biosynthesis in human tumor-induced macrophages contributes to their protumoral characteristics. J Immunother Cancer. 2020 Sep;8(2):e000638. doi: 10.1136/jitc-2020-000638.

Rajewsky N, Almouzni G, Gorski SA, Aerts S, Amit I, Bertero MG, Bock C, Bredenoord AL, Cavalli G, Chiocca S, Clevers H, De Strooper B, Eggert A, Ellenberg J, Fernández XM, Figlerowicz M, Gasser SM, Hubner N, Kjems J, Knoblich JA, Krabbe G, Lichter P, Linnarsson S, Marine JC, Marioni J, Marti-Renom MA, Netea MG, Nickel D, Nollmann M, Novak HR, Parkinson H, Piccolo S, Pinheiro I, Pombo A, Popp C, Reik W, Roman-Roman S, Rosenstiel P, Schultze JL, Stegle O, Tanay A, Testa G, Thanos D, Theis FJ, Torres-Padilla ME, Valencia A, Vallot C, van Oudenaarden A, Vidal M, Voet T; LifeTime Community. LifeTime and improving European healthcare through cell-based interceptive medicine. Nature. 2020 Sep 7. doi: 10.1038/s41586-020-2715-9

Schulte-Schrepping J, Reusch N, Paclik D, Baßler K, Schlickeiser S, Zhang B, Krämer B, Krammer T, Brumhard S, Bonaguro L, De Domenico E, Wendisch D, Grasshoff M, Kapellos TS, Beckstette M, Pecht T, Saglam A, Dietrich O, Mei HE, Schulz AR, Conrad C, Kunkel D, Vafadarnejad E, Xu CJ, Horne A, Herbert M, Drews A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, Müller-Redetzky H, Heim KM, Machleidt F, Uhrig A, Bosquillon de Jarcy L, Jürgens L, Stegemann M, Glösenkamp CR, Volk HD, Goffinet C, Landthaler M, Wyler E, Georg P, Schneider M, Dang-Heine C, Neuwinger N, Kappert K, Tauber R, Corman V, Raabe J, Kaiser KM, Vinh MT, Rieke G, Meisel C, Ulas T, Becker M, Geffers R, Witzenrath M, Drosten C, Suttorp N, von Kalle C, Kurth F, Händler K, Schultze JL, Aschenbrenner AC, Li Y, Nattermann J, Sawitzki B, Saliba AE, & Sander LE; Deutsche COVID-19 OMICS Initiative (DeCOI). Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment. Cell. 2020 Aug 5:S0092-8674(20)30992-2. doi: 10.1016/j.cell.2020.08.001

Willers M, Ulas T, Völlger L, Vogl T, Heinemann AS, Pirr S, Pagel J, Fehlhaber B, Halle O, Schöning J, Schreek S, Löber U, Essex M, Hombach P, Graspeuntner S, Basic M, Bleich A, Cloppenborg-Schmidt K, Künzel S, Jonigk D, Rupp J, Hansen G, Förster R, Baines JF, Härtel C, Schultze JL, Forslund SK, Roth J, & Viemann D. S100A8 and S100A9 are Important for Postnatal Development of Gut Microbiota and Immune System in Mice and Infants. Gastroenterology. 2020 Aug 14:S0016-5085(20)35058-7. doi: 10.1053/j.gastro.2020.08.019.

Cirovic, B., de Bree, L. C. J., Groh, L., Blok, B. A., Chan, J., van der Velden, W. J. F. M., Bremmers, M. E. J., van Crevel, R., Händler, K., Picelli, S., Schulte-Schrepping, J., Klee, K., Oosting, M., Koeken, V. A. C. M., van Ingen, J., Li, Y., Benn, C. S., Schultze, J. L., Joosten, L. A. B., Curtis, N., Netea, M. G. & Schlitzer, A. BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment. Cell Host Microbe (2020). doi:https://doi.org/10.1016/j.chom.2020.05.014

Neubert, P., Homann, A., Wendelborn, D., Bär, A.-L., Krampert, L., Trum, M., Schröder, A., Ebner, S., Weichselbaum, A., Schatz, V., Linz, P., Veelken, R., Schulte-Schrepping, J., Aschenbrenner, A. C., Quast, T., Kurts, C., Geisberger, S., Kunzelmann, K., Hammer, K., Binger, K. J., Titze, J., Müller, D. N., Kolanus, W., Schultze, J. L., Wagner, S. & Jantsch NCX1 represents an ionic Na+ sensing mechanism in macrophages. NCX1 represents an ionic Na+ sensing mechanism in macrophages. PLOS Biol. 18, e3000722 (2020)

Fischer-Riepe, L., Daber, N., Schulte-Schrepping, J., Véras De Carvalho, B. C., Russo, A., Pohlen, M., Fischer, J., Chasan, A. I., Wolf, M., Ulas, T., Glander, S., Schulz, C., Skryabin, B., Wollbrink, A., Steingraeber, N., Stremmel, C., Koehle, M., Gärtner, F., Vettorazzi, S., Holzinger, D., Gross, J., Rosenbauer, F., Stoll, M., Niemann, S., Tuckermann, J., Schultze, J. L., Roth, J. & Barczyk-Kahlert, K.CD163 expression defines specific, IRF8-dependent, immune-modulatory macrophages in the bone marrow. J. Allergy Clin. Immunol. (2020). doi:10.1016/j.jaci.2020.02.034

Georganaki, M., Ramachandran, M., Tuit, S., Núñez, N. G., Karampatzakis, A., Fotaki, G., van Hooren, L., Huang, H., Lugano, R., Ulas, T., Kaunisto, A., Holland, E. C., Ellmark, P., Mangsbo, S. M., Schultze, J., Essand, M., Tugues, S. & Dimberg, A. Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy. Oncoimmunology 9, 1730538 (2020).

Netea, M. G., Domínguez-Andrés, J., Barreiro, L. B., Chavakis, T., Divangahi, M., Fuchs, E., Joosten, L. A. B., van der Meer, J. W. M., Mhlanga, M. M., Mulder, W. J. M., Riksen, N. P., Schlitzer, A., Schultze, J. L., Stabell Benn, C., Sun, J. C., Xavier, R. J. & Latz, E. Defining trained immunity and its role in health and disease. Nat. Rev. Immunol. (2020). doi:10.1038/s41577-020-0285-6

Werner, Y., Mass, E., Ashok Kumar, P., Ulas, T., Händler, K., Horne, A., Klee, K., Lupp, A., Schütz, D., Saaber, F., Redecker, C., Schultze, J. L., Geissmann, F. & Stumm, R. Cxcr4 distinguishes HSC-derived monocytes from microglia and reveals monocyte immune responses to experimental stroke. Nat. Neurosci. (2020). doi:10.1038/s41593-020-0585-y

Liepelt, A., Hohlstein, P., Gussen, H., Xue, J., Aschenbrenner, C. A., Ulas, T., Buendgens, L., Warzecha, T. K., Bartneck, M., Luedde, T., Trautwein, C., Schultze, L. J., Koch, A. & Tacke, F. Differential Gene Expression in Circulating CD14+ Monocytes Indicates the Prognosis of Critically Ill Patients with Sepsis. J. Clin. Med. 9, (2020). doi.org/10.3390/jcm9010127

2019

Pecht, T., Aschenbrenner, A. C., Ulas, T. & Succurro, A. Modeling population heterogeneity from microbial communities to immune response in cells. Cell. Mol. Life Sci. (2019). doi:10.1007/s00018-019-03378-w

Warnat-Herresthal, S., Perrakis, K., Taschler, B., Becker, M., Baßler, K., Beyer, M., Günther, P., Schulte-Schrepping, J., Seep, L., Klee, K., Ulas, T., Haferlach, T., Mukherjee, S. & Schultze, J Scalable prediction of acute myeloid leukemia using high-dimensional machine learning and blood transcriptomics. iScience (2019). doi:10.1016/j.isci.2019.100780

Schultze, J. L. Specificity meets function. Nat. Immunol. 20, 1565–1567 (2019).

Camell, C. D., Günther, P., Lee, A., Goldberg, E. L., Spadaro, O., Youm, Y.-H., Bartke, A., Hubbard, G. B., Ikeno, Y., Ruddle, N. H., Schultze, J & Dixit, V. D. Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis. Cell Metab. (2019). doi:https://doi.org/10.1016/j.cmet.2019.10.006

Tuit, S., Salvagno, C., Kapellos, T. S., Hau, C.-S., Seep, L., Oestreich, M., Klee, K., de Visser, K. E., Ulas, T. & Schultze, J. L. Transcriptional Signature Derived from Murine Tumor-Associated Macrophages Correlates with Poor Outcome in Breast Cancer Patients. Cell Rep. 29, 1221-1235.e5 (2019).

Günther, P. & Schultze, J. L. Mind the Map: Technology Shapes the Myeloid Cell Space. Front. Immunol. 10, 2287 (2019).

Kapellos, T. S., Bonaguro, L., Gemünd, I., Reusch, N., Saglam, A., Hinkley, E. R. & Schultze, J. L. Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases. Front. Immunol. 10, 1–13 (2019).

Placek, K., Schultze, J. L. & Aschenbrenner, A. C. Epigenetic reprogramming of immune cells in injury, repair, and resolution. J. Clin. Invest. 129, 2994–3005 (2019).

Sundararajan, Z., Knoll, R., Hombach, P., Becker, M., Schultze, J. L. & Ulas, T. Shiny-Seq: advanced guided transcriptome analysis. BMC Res. Notes 12, 432 (2019).

Sloot, Y. J. E., Rabold, K., Ulas, T., De Graaf, D. M., Heinhuis, B., Händler, K., Schultze, J. L., Netea, M. G., Smit, J. W. A., Joosten, L. A. B. & Netea-Maier, R. T.Interplay between thyroid cancer cells and macrophages: effects on IL-32 mediated cell death and thyroid cancer cell migration. Cell. Oncol. (2019). doi:10.1007/s13402-019-00457-9

Schmidleithner L, Thabet Y, Schönfeld E, Köhne M, Sommer D, Abdullah Z, Sadlon T, Osei-Sarpong C, Subbaramaiah K, Copperi F, Haendler K, Varga T, Schanz O, Bourry S, Bassler K, Krebs W, Peters AE, Baumgart AK, Schneeweiss M, Klee K, Schmidt SV, Nüssing S, Sander J, Ohkura N, Waha A, Sparwasser T, Wunderlich FT, Förster I, Ulas T, Weighardt H, Sakaguchi S, Pfeifer A, Blüher M, Dannenberg AJ, Ferreirós N, Muglia LJ, Wickenhauser C, Barry SC, Schultze JL & Beyer M.Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction. Immunity. 2019 Apr 15

Placek K, Schultze JL, Netea MG. Immune memory characteristics of innate lymphoid cells. Curr Opin Infect Dis. 2019 Jun

Goossens, P., Rodriguez-Vita, J., Etzerodt, A., Masse, M., Rastoin, O., Gouirand, V., Ulas, T., Papantonopoulou, O., Van Eck, M., Auphan-Anezin, N., Bebien, M., Verthuy, C., Vu Manh, T. P., Turner, M., Dalod, M., Schultze, J. L. & Lawrence, T. Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression. Cell Metab. (2019)

Civit, L., Theodorou, I., Frey, F., Weber, H., Lingnau, A., Gröber, C., Blank, M., Dambrune, C., Stunden, J., Beyer, M., Schultze, J., Latz, E., Ducongé, F., Kubbutat, M. H. G. & Mayer, G. Targeting hormone refractory prostate cancer by in vivo selected DNA libraries in an orthotopic xenograft mouse model. Sci. Rep. 9, 4976 (2019)

Salvagno, C., Ciampricotti, M., Tuit, S., Hau, C.-S., van Weverwijk, A., Coffelt, S. B., Kersten, K., Vrijland, K., Kos, K., Ulas, T., Song, J.-Y., Ooi, C.-H., Rüttinger, D., Cassier, P. A., Jonkers, J., Schultze, J. L., Ries, C. H. & de Visser, K. E. Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response. Nat. Cell Biol. (2019)

an der Poel, M., Ulas, T., Mizee, M. R., Hsiao, C.-C., Miedema, S. S. M., Adelia, Schuurman, K. G., Helder, B., Tas, S. W., Schultze, J. L., Hamann, J. & Huitinga, I. Transcriptional profiling of human microglia reveals grey–white matter heterogeneity and multiple sclerosis-associated changes Nat. Comm. (2019).

Schultze, J. L., Mass, E. & Schlitzer, A. Emerging Principles in Myelopoiesis at Homeostasis and during Infection and Inflammation. Immunity 50, 288–301 (2019).

Schultze, J. L.Myocardial infarction cell by cell. Nat. Immunol. 20, 7–9 (2019).

Bassler, K., Schulte-Schrepping, J., Warnat-Herresthal, S., Aschenbrenner, A. C. & Schultze, J. L.The Myeloid Cell Compartment—Cell by Cell. Annu. Rev. Immunol. (2019). doi:10.1146/annurev-immunol-042718-041728

Netea, M. G., Schlitzer, A., Placek, K., Joosten, L. A. B. & Schultze, J. L.Innate and Adaptive Immune Memory: an Evolutionary Continuum in the Host’s Response to Pathogens. Cell Host Microbe 25, 13–26 (2019).

2018

Rakers, C., Schleif, M., Blank, N., Matušková, H., Ulas, T., Händler, K., Torres, S. V., Schumacher, T., Tai, K., Schultze, J. L., Jackson, W. S. & Petzold, G. C. Stroke target identification guided by astrocyte transcriptome analysisStroke target identification guided by astrocyte transcriptome analysis. Glia 619–633 (2018).

Kabrani, E., Chu, V. T., Tasouri, E., Sommermann, T., Baßler, K., Ulas, T., Zenz, T., Bullinger, L., Schultze, J.L., Rajewsky, K. & Sander, S. Nuclear FOXO1 promotes lymphomagenesis in germinal center B cells. Blood (2018). doi:10.1182/blood-2018-06-856203

Ravussin, A., Youm, Y. H., Sander, J., Ryu, S., Nguyen, K., Varela, L., Shulman, G. I., Sidorov, S., Horvath, T. L., Schultze, J. L. & Dixit, V. D. Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity. Cell Rep. 24, 1085–1092.e6 (2018).

Pfeiffer, F., Gröber, C., Blank, M., Händler, K., Beyer, M., Schultze, J. L. & Mayer, G. Systematic evaluation of error rates and causes in short samples in next-generation sequencing. Sci. Rep. 8, 1–14 (2018).

Doebbeler, M., Koenig, C., Krzyzak, L., Seitz, C., Wild, A., Ulas, T., Baßler, K., Kopelyanskiy, D., Butterhof, A., Kuhnt, C., Kreiser, S., Stich, L., Zinser, E., Knippertz, I., Wirtz, S., Riegel, C., Hoffmann, P., Edinger, M., Nitschke, L., Winkler, T., Schultze, J. L., Steinkasserer, A. & Lechmann, M. CD83 expression is essential for Treg cell differentiation and stability. JCI Insight 3, (2018).

Bickert, A., Kern, P., van Uelft, M., Herresthal, S., Ulas, T., Gutbrod, K., Breiden, B., Degen, J., Sandhoff, K., Schultze, J. L., Dörmann, P., Hartmann, D., Bauer, R. & Willecke, K. Inactivation of ceramide synthase 2 catalytic activity in mice affects transcription of genes involved in lipid metabolism and cell division.Biochim. Biophys. Acta - Mol. Cell Biol. Lipids 1863, 734–749 (2018).

Vogl, T., Stratis, A., Wixler, V., Völler, T., Thurainayagam, S., Jorch, S. K., Zenker, S., Dreiling, A., Chakraborty, D., Fröhling, M., Paruzel, P., Wehmeyer, C., Hermann, S., Papantonopoulou, O., Geyer, C., Loser, K., Schäfers, M., Ludwig, S., Stoll, M., Leanderson, T., Schultze, J. L., König, S., Pap, T. & Roth, J. Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation J. Clin. Invest. 128, 1852–1866 (2018).

Schultze, J. L., SYSCID consortium, Rosenstiel P.Systems Medicine in Chronic Inflammatory Diseases.. Immunity (2018).

Pan WH, Sommer F, Falk-Paulsen M, Ulas T, Best P, Fazio A, Kachroo P, Luzius A, Jentzsch M, Rehman A, Müller F, Lengauer T, Walter J, Künzel S, Baines JF, Schreiber S, Franke A, Schultze, J. L., Bäckhed F, Rosenstiel P. Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development. Genome Med. (2018).

Bickert A, Kern P, van Uelft M, Herresthal S, Ulas T, Gutbrod K, Breiden B, Degen J, Sandhoff K, Schultze, J. L., Dörmann P, Hartmann D, Bauer R, Willecke K. Inactivation of ceramide synthase 2 catalytic activity in mice affects transcription of genes involved in lipid metabolism and cell division.. Biophys Acta. (2018).

Vogl T, Stratis A, Wixler V, Völler T, Thurainayagam S, Jorch SK, Zenker S, Dreiling A, Chakraborty D, Fröhling M, Paruzel P, Wehmeyer C, Hermann S, Papantonopoulou O, Geyer C, Loser K, Schäfers M, Ludwig S, Stoll M, Leanderson T, Schultze, J. L., König S, Pap T, Roth J.Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation. J Clin Invest (2018).

Wendeln AC, Degenhardt K, Kaurani L, Gertig M, Ulas T, Jain G, Wagner J, Häsler LM, Wild K, Skodras A, Blank T, Staszewski O, Datta M, Centeno TP, Capece V, Islam MR, Kerimoglu C, Staufenbiel M, Schultze, J. L., Beyer M, Prinz M, Jucker M, Fischer A, Neher JJ.Innate immune memory in the brain shapes neurological disease hallmarks. Nature (2018).

Gulei, D., Irimie, A. I., Cojocneanu-Petric, R., Schultze, J. L. and Berindan-Neagoe, I Exosomes-Small Players, Big Sound.. Bioconjug. Chem. 29, 635–648 (2018).

Schultze, J. L. & Aschenbrenner, A. C. Systems immunology allows a new view on human dendritic cells.. Semin. Cell Dev. Biol. (2018).

Fulle, L., Steiner, N., Funke, M., Gondorf, F., Pfeiffer, F., Siegl, J., Opitz, F. V, Hassel, S. K., Erazo, A. B., Schanz, O., Stunden, H. J., Blank, M., Grober, C., Handler, K., Beyer, M., Weighardt, H., Latz, E., Schultze, J. L., Mayer, G. and Forster, I. RNA Aptamers Recognizing Murine CCL17 Inhibit T Cell Chemotaxis and Reduce Contact Hypersensitivity. In Vivo. Mol. Ther (2018).

Thion, M. S., Low, D., Silvin, A., Chen, J., Grisel, P., Schulte-Schrepping, J., Blecher, R., Ulas, T., Squarzoni, P., Hoeffel, G., Coulpier, F., Siopi, E., David, F. S., Scholz, C., Shihui, F., Lum, J., Amoyo, A. A., Larbi, A., Poidinger, M., Buttgereit, A., Lledo, P.-M., Greter, M., Chan, J. K. Y., Amit, I., Beyer, M., Schultze, J. L., Schlitzer, A., Pettersson, S., Ginhoux, F. Garel, S. J. Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner.. Cell 172, 500–516.e16 (2018).

Christ, A., Gunther, P., Lauterbach, M. A. R., Duewell, P., Biswas, D., Pelka, K., Scholz, C. J., Oosting, M., Haendler, K., Bassler, K., Klee, K., Schulte-Schrepping, J., Ulas, T., Moorlag, S. J. C. F. M., Kumar, V., Park, M. H., Joosten, L. A. B., Groh, L. A., Riksen, N. P., Espevik, T., Schlitzer, A., Li, Y., Fitzgerald, M. L., Netea, M. G., Schultze, J. L. and Latz, E. Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming.. Cell 172, 162–175.e14 (2018).

Mitroulis, I., Ruppova, K., Wang, B., Chen, L.-S., Grzybek, M., Grinenko, T., Eugster, A., Troullinaki, M., Palladini, A., Kourtzelis, I., Chatzigeorgiou, A., Schlitzer, A., Beyer, M., Joosten, L. A. B., Isermann, B., Lesche, M., Petzold, A., Simons, K., Henry, I., Dahl, A., Schultze, J. L., Wielockx, B., Zamboni, N., Mirtschink, P., Coskun, U., Hajishengallis, G., Netea, M. G. and Chavakis, T. Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity.Cell 172, 147–161.e12 (2018).

Ulas, T., Schultze, J. L. and Beyer, M. Bioinformatic Assessment of Macrophage Activation by the Innate Immune System. Methods Mol. Biol. 1714, 19–40 (2018).

2017

Wischhof, L., Maida, S., Piazzesi, A., Gioran, A., Barragan Sanz, K., Irsen, S., Beyer, M., Schultze, J. L., Dyer, M. J., Salomoni, P., Ehninger, D., Nicotera, P. and Bano, D. The SWI/SNF subunit Bcl7a contributes to motor coordination and Purkinje cell function. Sci. Rep. 7, 17055 (2017).

Sander, J., Schmidt, S. V, Cirovic, B., McGovern, N., Papantonopoulou, O., Hardt, A.-L., Aschenbrenner, A. C., Kreer, C., Quast, T., Xu, A. M., Schmidleithner, L. M., Theis, H., Thi Huong, L. Do, Sumatoh, H. R. Bin, Lauterbach, M. A. R., Schulte-Schrepping, J., Gunther, P., Xue, J., Bassler, K., Ulas, T., Klee, K., Katzmarski, N., Herresthal, S., Krebs, W., Martin, B., Latz, E., Handler, K., Kraut, M., Kolanus, W., Beyer, M., Falk, C. S., Wiegmann, B., Burgdorf, S., Melosh, N. A., Newell, E. W., Ginhoux, F., Schlitzer, A. and Schultze, J. L.Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2. Immunity 47, 1051–1066.e12 (2017).

Hosel, M., Quasdorff, M., Ringelhan, M., Kashkar, H., Debey-Pascher, S., Sprinzl, M. F., Bockmann, J.-H., Arzberger, S., Webb, D., von Olshausen, G., Weber, A., Schultze, J. L., Buning, H., Heikenwalder, M. and Protzer, U. Hepatitis B Virus Activates Signal Transducer and Activator of Transcription 3 Supporting Hepatocyte Survival and Virus Replication. Cell. Mol. Gastroenterol. Hepatol. 4, 339–363 (2017).

Camell, C. D., Sander, J., Spadaro, O., Lee, A., Nguyen, K. Y., Wing, A., Goldberg, E. L., Youm, Y.-H., Brown, C. W., Elsworth, J., Rodeheffer, M. S., Schultze, J. L. and Dixit, V. D. Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing. Nature 550, 119–123 (2017).

Bilkei-Gorzo, A., Albayram, O., Draffehn, A., Michel, K., Piyanova, A., Oppenheimer, H., Dvir-Ginzberg, M., Racz, I., Ulas, T., Imbeault, S., Bab, I., Schultze, J. L. and Zimmer, A. A chronic low dose of Delta(9)-tetrahydrocannabinol (THC) restores cognitive function in old mice. Nat. Med. 23, 782–787 (2017).

See, P., Dutertre, C.-A., Chen, J., Gunther, P., McGovern, N., Irac, S. E., Gunawan, M., Beyer, M., Handler, K., Duan, K., Sumatoh, H. R. Bin, Ruffin, N., Jouve, M., Gea-Mallorqui, E., Hennekam, R. C. M., Lim, T., Yip, C. C., Wen, M., Malleret, B., Low, I., Shadan, N. B., Fen, C. F. S., Tay, A., Lum, J., Zolezzi, F., Larbi, A., Poidinger, M., Chan, J. K. Y., Chen, Q., Renia, L., Haniffa, M., Benaroch, P., Schlitzer, A., Schultze, J. L., Newell, E. W. and Ginhoux, F. Mapping the human DC lineage through the integration of high-dimensional techniques. Science 356, (2017).

Aschenbrenner, A. C., Bassler, K., Brondolin, M., Bonaguro, L., Carrera, P., Klee, K., Ulas, T., Schultze, J. L. and Hoch, M. A cross-species approach to identify transcriptional regulators exemplified for Dnajc22 and Hnf4a. Sci. Rep. 7, 4056 (2017).

Ulas, T., Pirr, S., Fehlhaber, B., Bickes, M. S., Loof, T. G., Vogl, T., Mellinger, L., Heinemann, A. S., Burgmann, J., Schoning, J., Schreek, S., Pfeifer, S., Reuner, F., Vollger, L., Stanulla, M., von Kockritz-Blickwede, M., Glander, S., Barczyk-Kahlert, K., von Kaisenberg, C. S., Friesenhagen, J., Fischer-Riepe, L., Zenker, S., Schultze, J. L., Roth, J. and Viemann, D.S100-alarmin-induced innate immune programming protects newborn infants from sepsis. Nat. Immunol. 18, 622–632 (2017).

Aschenbrenner, A. C. and Schultze, J. L.New ‘programmers’ in tissue macrophage activation. Pflugers Arch. 469, 375–383 (2017).

Sander, J., Schultze, J. L. and Yosef, N. ImpulseDE: detection of differentially expressed genes in time series data using impulse models. Bioinformatics 33, 757–759 (2017).

Schlitzer, A. and Schultze, J. L.Tissue-resident macrophages - how to humanize our knowledge. Immunol. Cell Biol. 95, 173–177 (2017).

Schultze, J. L.Chromatin Remodeling in Monocyte and Macrophage Activation. Adv. Protein Chem. Struct. Biol. 106, 1–15 (2017).

Heine, A., Held, S. A. E., Schulte-Schrepping, J., Wolff, J. F. A., Klee, K., Ulas, T., Schmacke, N. A., Daecke, S. N., Riethausen, K., Schultze, J. L. and Brossart, P. Generation and functional characterization of MDSC-like cells. Oncoimmunology 6, e1295203 (2017).

2016

Heidkamp, G. F., Sander, J., Lehmann, C. H. K., Heger, L., Eissing, N., Baranska, A., Luhr, J. J., Hoffmann, A., Reimer, K. C., Lux, A., Soder, S., Hartmann, A., Zenk, J., Ulas, T., McGovern, N., Alexiou, C., Spriewald, B., Mackensen, A., Schuler, G., Schauf, B., Forster, A., Repp, R., Fasching, P. A., Purbojo, A., Cesnjevar, R., Ullrich, E., Ginhoux, F., Schlitzer, A., Nimmerjahn, F., Schultze, J. L. and Dudziak, D. Human lymphoid organ dendritic cell identity is predominantly dictated by ontogeny, not tissue microenvironment. Sci. Immunol. 1, (2016).

Stunnenberg, H. G. and Hirst, M. The International Human Epigenome Consortium: The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery. Cell 167, 1145–1149 (2016).

Durek, P., Nordstrom, K., Gasparoni, G., Salhab, A., Kressler, C., de Almeida, M., Bassler, K., Ulas, T., Schmidt, F., Xiong, J., Glazar, P., Klironomos, F., Sinha, A., Kinkley, S., Yang, X., Arrigoni, L., Amirabad, A. D., Ardakani, F. B., Feuerbach, L., Gorka, O., Ebert, P., Muller, F., Li, N., Frischbutter, S., Schlickeiser, S., Cendon, C., Frohler, S., Felder, B., Gasparoni, N., Imbusch, C. D., Hutter, B., Zipprich, G., Tauchmann, Y., Reinke, S., Wassilew, G., Hoffmann, U., Richter, A. S., Sieverling, L., Chang, H.-D., Syrbe, U., Kalus, U., Eils, J., Brors, B., Manke, T., Ruland, J., Lengauer, T., Rajewsky, N., Chen, W., Dong, J., Sawitzki, B., Chung, H.-R., Rosenstiel, P., Schulz, M. H., Schultze, J. L., Radbruch, A., Walter, J., Hamann, A. & Polansky, J. K. Epigenomic Profiling of Human CD4+ T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development.. 10.1016/j.immuni.2016.10.022.

Tedeschi, A., Dupraz, S., Laskowski, C. J., Xue, J., Ulas, T., Beyer, M., Schultze, J. L. & Bradke The Calcium Channel Subunit Alpha2delta2 Suppresses Axon Regeneration in the Adult CNS.. 10.1016/j.neuron.2016.09.026. Epub 2016 Oct 6.

Schlitzer A, Schultze JL.Tissue?resident macrophages — how to humanize our knowledge. 10.1038/icb.2016.82. Epub 2016 Oct 18.

Schuette, V., Embgenbroich, M., Ulas, T., Welz, M., Schulte-Schrepping, J., Draffehn, A. M., Quast, T., Koch, K., Nehring, M., Konig, J., Zweynert, A., Harms, F. L., Steiner, N., Limmer, A., Forster, I., Berberich-Siebelt, F., Knolle, P. A., Wohlleber, D., Kolanus, W., Beyer, M., Schultze, J. L. & Burgdorf, S. Mannose receptor induces T-cell tolerance via inhibition of CD45 and up-regulation of CTLA-4. 10.1073/pnas.1605885113. Epub 2016 Sep 6.

Mass, E., Ballesteros, I., Farlik, M., Halbritter, F., Gunther, P., Crozet, L., Jacome-Galarza, C. E., Handler, K., Klughammer, J., Kobayashi, Y., Gomez-Perdiguero, E., Schultze, J. L., Beyer, M., Bock, C. & Geissmann, F. Specification of tissue-resident macrophages during organogenesis. 10.1126/science.aaf4238. Epub 2016 Aug 4.

Schultze, J. L. Macrophage tolerance in the gut: It is in the epigenome! 10.1002/eji.201646545.

Szulzewsky, F., Arora, S., de Witte, L., Ulas, T., Markovic, D., Schultze, J. L., Holland, E. C., Synowitz, M., Wolf, S. A. & Kettenmann, H. Human glioblastoma-associated microglia/monocytes express a distinct RNA profile compared to human control and murine samples. Glia 64, 1416–1436 (2016).

Hagemeyer, N., Kierdorf, K., Frenzel, K., Xue, J., Ringelhan, M., Abdullah, Z., Godin, I., Wieghofer, P., Costa Jordao, M. J., Ulas, T., Yorgancioglu, G., Rosenbauer, F., Knolle, P. A., Heikenwalder, M., Schultze, J. L. & Prinz, M. Transcriptome?based profiling of yolk sac?derived macrophages reveals a role for Irf8 in macrophage maturation. EMBO J. 35, 1730–1744 (2016).

Carl-Philipp Hackstein, Lisa Mareike Assmus, Meike Welz, Sabine Klein, Timo Schwandt, Joachim Schultze, Irmgard Förster, Fabian Gondorf, Marc Beyer, Daniela Kroy, Christian Kurts, Jonel Trebicka, Wolfgang Kastenmüller, Percy A Knolle, Zeinab Abdullah Gut microbial translocation corrupts myeloid cell function to control bacterial infection during liver cirrhosis. 10.1136/gutjnl-2015-311224. Epub 2016 Jul 18.

Beins, E., Ulas, T., Ternes, S., Neumann, H., Schultze, J. L., Zimmer, A. Characterization of inflammatory markers and transcriptome profiles of differentially activated embryonic stem cell?derived microglia. 10.1002/glia.22979. Epub 2016 Mar 9.

Brandstatter, O., Schanz, O., Vorac, J., Konig, J., Mori, T., Maruyama, T., Korkowski, M., Haarmann-Stemmann, T., von Smolinski, D., Schultze, J. L., Abel, J., Esser, C., Takeyama, H., Weighardt, H., Forster, I. Balancing intestinal and systemic inflammation through cell type-specific expression of the aryl hydrocarbon receptor repressor. 10.1038/srep26091.

Beyer, M., Abdullah, Z., Chemnitz, J. M., Maisel, D., Sander, J., Lehmann, C., Thabet, Y., Shinde, P. V, Schmidleithner, L., Kohne, M., Trebicka, J., Schierwagen, R., Hofmann, A., Popov, A., Lang, K. S., Oxenius, A., Buch, T., Kurts, C., Heikenwalder, M., Fatkenheuer, G., Lang, P. A., Hartmann, P., Knolle, P. A., Schultze, J. L. Tumor-necrosis factor impairs CD4+ T cell–mediated immunological control in chronic viral infection. 10.1038/ni.3399. Epub 2016 Mar 7.

Sorg, U. R., Behnke, K., Degrandi, D., Reich, M., Keitel, V., Herebian, D., Deenen, R., Beyer, M., Schultze, J. L., Kohrer, K., Gabbert, H. E., Mayatepek, E., Haussinger, D., Pfeffer, K. Cooperative role of lymphotoxin ? receptor and tumor necrosis factor receptor p55 in murine liver regeneration. 10.1016/j.jhep.2015.12.006. Epub 2015 Dec 19.

Zimmer, S., Grebe, A., Bakke, S. S., Bode, N., Halvorsen, B., Ulas, T., Skjelland, M., De Nardo, D., Labzin, L. I., Kerksiek, A., Hempel, C., Heneka, M. T., Hawxhurst, V., Fitzgerald, M. L., Trebicka, J., Bjorkhem, I., Gustafsson, J.-A., Westerterp, M., Tall, A. R., Wright, S. D., Espevik, T., Schultze, J. L., Nickenig, G., Lutjohann, D., Latz, E. Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming. 10.1126/scitranslmed.aad6100.

Shahbazi, E., Moradi, S., Nemati, S., Satarian, L., Basiri, M., Gourabi, H., Zare Mehrjardi, N., Gunther, P., Lampert, A., Handler, K., Hatay, F. F., Schmidt, D., Molcanyi, M., Hescheler, J., Schultze, J. L., Saric, T., Baharvand, H. Conversion of Human Fibroblasts to Stably Self-Renewing Neural Stem Cells with a Single Zinc-Finger Transcription Factor. 10.1016/j.stemcr.2016.02.013. Epub 2016 Mar 24.

Ginhoux, F., Schultze, J. L., Murray, P. J., Ochando, J., Biswas, S. K. New insights into the multidimensional concept of macrophage ontogeny, activation and function. 10.1038/ni.3324.

Deng, M., Bragelmann, J., Schultze, J. L., Perner, S. Web-TCGA: an online platform for integrated analysis of molecular cancer data sets. 10.1186/s12859-016-0917-9.

Schmidt, S. V, Krebs, W., Ulas, T., Xue, J., Bassler, K., Gunther, P., Hardt, A.-L., Schultze, H., Sander, J., Klee, K., Theis, H., Kraut, M., Beyer, M., Schultze, J. L. The transcriptional regulator network of human inflammatory macrophages is defined by open chromatin. 10.1038/cr.2016.1. Epub 2016 Jan 5.

Schultze, J. L., Beyer, M. Myelopoiesis Reloaded: Single-Cell Transcriptomics Leads the Way. 10.1016/j.immuni.2015.12.019.

Schultze, J. L. Reprogramming of macrophages — new opportunities for therapeutic targeting. 10.1016/j.coph.2015.09.007. Epub 2015 Sep 29.

Aschenbrenner, A. C., Bassler, K., Brondolin, M., Bonaguro, L., Carrera, P., Klee, K., Ulas, T., Schultze, J. L. and Hoch, M. A cross-species approach to identify transcriptional regulators exemplified for Dnajc22 and Hnf4a. Sci. Rep. 7, 4056 (2017).

2015

Schultze, J. L. & Schmidt, S. V. Molecular features of macrophage activation. Semin. Immunol. 27, 416–423 (2015).

Milanez-Almeida, P., Ulas, T., Pasztoi, M., Glage, S., Schughart, K., Lutz, M. B., Schultze, J. L. & Huehn, J. CD11b+Ly6C++Ly6G- Cells with Suppressive Activity Towards T Cells Accumulate in Lungs of Influenza a Virus-Infected Mice. Eur. J. Microbiol. Immunol. (Bp). 5, 246–255 (2015).

Vacchelli, E., Ma, Y., Baracco, E. E., Sistigu, A., Enot, D. P., Pietrocola, F., Yang, H., Adjemian, S., Chaba, K., Semeraro, M., Signore, M., De Ninno, A., Lucarini, V., Peschiaroli, F., Businaro, L., Gerardino, A., Manic, G., Ulas, T., Gunther, P., Schultze, J. L., Kepp, O., Stoll, G., Lefebvre, C., Mulot, C., Castoldi, F., Rusakiewicz, S., Ladoire, S., Apetoh, L., Bravo-San Pedro, J. M., Lucattelli, M., Delarasse, C., Boige, V., Ducreux, M., Delaloge, S., Borg, C., Andre, F., Schiavoni, G., Vitale, I., Laurent-Puig, P., Mattei, F., Zitvogel, L. & Kroemer, G. Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1. Science 350, 972–978 (2015).

Labzin, L. I., Schmidt, S. V, Masters, S. L., Beyer, M., Krebs, W., Klee, K., Stahl, R., Lutjohann, D., Schultze, J. L., Latz, E. & De Nardo, D. ATF3 Is a Key Regulator of Macrophage IFN Responses. J. Immunol. 195, 4446–4455 (2015).

Bottcher, J. P., Beyer, M., Meissner, F., Abdullah, Z., Sander, J., Hochst, B., Eickhoff, S., Rieckmann, J. C., Russo, C., Bauer, T., Flecken, T., Giesen, D., Engel, D., Jung, S., Busch, D. H., Protzer, U., Thimme, R., Mann, M., Kurts, C., Schultze, J. L., Kastenmuller, W. & Knolle, P. A. Functional classification of memory CD8+ T cells by CX3CR1 expression. Nat. Commun. 6, 8306 (2015).

Schultze, J. L., Schmieder, A. & Goerdt, S. Macrophage activation in human diseases. Semin. Immunol. 27, 249–256 (2015).

Schultze, J. L. Teaching 'big data' analysis to young immunologists. Nat. Immunol. 16, 902–905 (2015).

Schultze, J. L. Transcriptional programming of human macrophages: on the way to systems immunology. J. Mol. Med. (Berl). 93, 589–597 (2015).

Mitschka, S., Ulas, T., Goller, T., Schneider, K., Egert, A., Mertens, J., Brustle, O., Schorle, H., Beyer, M., Klee, K., Xue, J., Gunther, P., Bassler, K., Schultze, J. L. & Kolanus, W. Co-existence of intact stemness and priming of neural differentiation programs in mES cells lacking Trim71Sci. Rep. 5, 11126 (2015).

Sommer, D., Peters, A. E., Wirtz, T., Mai, M., Ackermann, J., Thabet, Y., Schmidt, J., Weighardt, H., Wunderlich, F. T., Degen, J., Schultze, J. L. & Beyer, M. Efficient genome engineering by targeted homologous recombination in mouse embryos using transcription activator-like effector nucleasesNature communications 6, 5927 (2015).

Fassl, S. K., Austermann, J., Papantonopoulou, O., Riemenschneider, M., Xue, J., Bertheloot, D., Freise, N., Spiekermann, C., Witten, A., Viemann, D., Kirschnek, S., Stoll, M., Latz, E., Schultze, J. L., Roth, J. & Vogl, T. Transcriptome Assessment Reveals a Dominant Role for TLR4 in the Activation of Human Monocytes by the Alarmin MRP8. J. Immunol. 194, 575–583 (2015).

Austermann, J., Friesenhagen, J., Fassl, S. K., Petersen, B., Ortkras, T., Burgmann, J., Barczyk-Kahlert, K., Faist, E., Zedler, S., Pirr, S., Rohde, C., Muller-Tidow, C., von Kockritz-Blickwede, M., von Kaisenberg, C. S., Flohe, S. B., Ulas, T., Schultze, J. L., Roth, J., Vogl, T. & Viemann, D. Alarmins MRP8 and MRP14 Induce Stress Tolerance in Phagocytes under Sterile Inflammatory Conditions. Cell Rep. 9, 2112–2123 (2014).

Krebs, W., Schmidt, S. V, Goren, A., De Nardo, D., Labzin, L., Bovier, A., Ulas, T., Theis, H., Kraut, M., Latz, E., Beyer, M. & Schultze, J. L. Optimization of transcription factor binding map accuracy utilizing knockout-mouse modelsNucleic Acids Res. 42, 13051–13060 (2014).

Sistigu, A., Yamazaki, T., Vacchelli, E., Chaba, K., Enot, D. P., Adam, J., Vitale, I., Goubar, A., Baracco, E. E., Remedios, C., Fend, L., Hannani, D., Aymeric, L., Ma, Y., Niso-Santano, M., Kepp, O., Schultze, J. L., Tuting, T., Belardelli, F., Bracci, L., La Sorsa, V., Ziccheddu, G., Sestili, P., Urbani, F., Delorenzi, M., Lacroix-Triki, M., Quidville, V., Conforti, R., Spano, J.-P., Pusztai, L., Poirier-Colame, V., Delaloge, S., Penault-Llorca, F., Ladoire, S., Arnould, L., Cyrta, J., Dessoliers, M.-C., Eggermont, A., Bianchi, M. E., Pittet, M., Engblom, C., Pfirschke, C., Preville, X., Uze, G., Schreiber, R. D., Chow, M. T., Smyth, M. J., Proietti, E., Andre, F., Kroemer, G. & Zitvogel, L. Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapyNat. Med. 20, 1301–1309 (2014).

Schmole, A.-C., Lundt, R., Ternes, S., Albayram, O., Ulas, T., Schultze, J. L., Bano, D., Nicotera, P., Alferink, J. & Zimmer, A. Cannabinoid receptor 2 deficiency results in reduced neuroinflammation in an Alzheimer's disease mouse model. Neurobiol. Aging 36, 710–719 (2015).

2014

Bottcher, J. P., Schanz, O., Garbers, C., Zaremba, A., Hegenbarth, S., Kurts, C., Beyer, M., Schultze, J. L., Kastenmuller, W., Rose-John, S. & Knolle, P. A. IL-6 trans-Signaling-Dependent Rapid Development of Cytotoxic CD8+ T Cell FunctionCell Rep. 8, 1318–1327 (2014).

Schmidt, S. V & Schultze, J. L. New insights into IDO biology in bacterial and viral infectionsFront. Immunol. 5, 384 (2014).

Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., Locati, M., Mantovani, A., Martinez, F. O., Mege, J.-L., Mosser, D. M., Natoli, G., Saeij, J. P., Schultze, J. L., Shirey, K. A., Sica, A., Suttles, J., Udalova, I., van Ginderachter, J. A., Vogel, S. N. & Wynn, T. A. Macrophage activation and polarization: nomenclature and experimental guidelines.Immunity 41, 14–20 (2014).

Kummer, M. P., Hammerschmidt, T., Martinez, A., Terwel, D., Eichele, G., Witten, A., Figura, S., Stoll, M., Schwartz, S., Pape, H.-C., Schultze, J. L., Weinshenker, D., Heneka, M. T. & Urban, I. Ear2 Deletion Causes Early Memory and Learning Deficits in APP/PS1 MiceJ. Neurosci. 34, 8845–8854 (2014).

Schultze, J. L., Freeman, T., Hume, D. A. & Latz, E. A transcriptional perspective on human macrophage biologySemin. Immunol. 27, 44–50 (2015).

Xue, J., Schmidt, S. V, Sander, J., Draffehn, A., Krebs, W., Quester, I., De Nardo, D., Gohel, T. D., Emde, M., Schmidleithner, L., Ganesan, H., Nino-Castro, A., Mallmann, M. R., Labzin, L., Theis, H., Kraut, M., Beyer, M., Latz, E., Freeman, T. C., Ulas, T. & Schultze, J. L. Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation. Immunity 40, 274–288 (2014).

Globisch, T., Steiner, N., Fulle, L., Lukacs-Kornek, V., Degrandi, D., Dresing, P., Alferink, J., Lang, R., Pfeffer, K., Beyer, M., Weighardt, H., Kurts, C., Ulas, T., Schultze, J. L. & Forster, I. Cytokine‐dependent regulation of dendritic cell differentiation in the splenic microenvironmentEur. J. Immunol. 44, 500–510 (2014).

Sommer, D., Peters, A., Wirtz, T., Mai, M., Ackermann, J., Thabet, Y., Schmidt, J., Weighardt, H., Wunderlich, F. T., Degen, J., Schultze, J. L. & Beyer, M. Efficient genome engineering by targeted homologous recombination in mouse embryos using transcription activator-like effector nucleasesNat. Commun. 5, 3045 (2014).

Ma, Y., Mattarollo, S. R., Adjemian, S., Yang, H., Aymeric, L., Hannani, D., Portela Catani, J. P., Duret, H., Teng, M. W. L., Kepp, O., Wang, Y., Sistigu, A., Schultze, J. L., Stoll, G., Galluzzi, L., Zitvogel, L., Smyth, M. J. & Kroemer, G. CCL2/CCR2-Dependent Recruitment of Functional Antigen-Presenting Cells into Tumors upon ChemotherapyCancer Res. 74, 436–445 (2014).

De Nardo, D., Labzin, L. I., Kono, H., Seki, R., Schmidt, S. V, Beyer, M., Xu, D., Zimmer, S., Lahrmann, C., Schildberg, F. A., Vogelhuber, J., Kraut, M., Ulas, T., Kerksiek, A., Krebs, W., Bode, N., Grebe, A., Fitzgerald, M. L., Hernandez, N. J., Williams, B. R. G., Knolle, P., Kneilling, M., Rocken, M., Lutjohann, D., Wright, S. D., Schultze, J. L. & Latz, E. High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3Nat. Immunol. 15, 152–160 (2014).

2013

Lubkemeier, I., Andrie, R., Lickfett, L., Bosen, F., Stockigt, F., Dobrowolski, R., Draffehn, A. M., Fregeac, J., Schultze, J. L., Bukauskas, F. F., Schrickel, J. W. & Willecke, K. The Connexin40A96S mutation from a patient with atrial fibrillation causes decreased atrial conduction velocities and sustained episodes of induced atrial fibrillation in mice.J. Mol. Cell. Cardiol. 65, 19–32 (2013).

Schermer, B., Bartels, V., Frommolt, P., Habermann, B., Braun, F., Schultze, J. L., Roodbergen, M., Hoeijmakers, J. H., Schumacher, B., Nurnberg, P., Dolle, M. E., Benzing, T., Muller, R.-U. & Kurschat, C. E. Transcriptional profiling reveals progeroid Ercc1-/Δ mice as a model system for glomerular aging. BMC Genomics 14, 559 (2013).

Nino-Castro, A., Abdullah, Z., Popov, A., Thabet, Y., Beyer, M., Knolle, P., Domann, E., Chakraborty, T., Schmidt, S. V & Schultze, J. L.The IDO1-induced kynurenines play a major role in the antimicrobial effect of human myeloid cells against Listeria monocytogenes. Innate Immun. 20, 401–411 (2014).

Langhans, B., Kramer, B., Louis, M., Nischalke, H. D., Huneburg, R., Staratschek-Jox, A., Odenthal, M., Manekeller, S., Schepke, M., Kalff, J., Fischer, H.-P., Schultze, J. L. & Spengler, U. Intrahepatic IL-8 producing Foxp3(+)CD4(+) regulatory T cells and fibrogenesis in chronic hepatitis.C. J. Hepatol. 59, 229–235 (2013).

Beutner, C., Linnartz-Gerlach, B., Schmidt, S. V, Beyer, M., Mallmann, M. R., Staratschek-Jox, A., Schultze, J. L. & Neumann, H. Unique transcriptome signature of mouse microglia. Glia 61, 1429–1442 (2013).

Jux, B., Staratschek-Jox, A., Penninger, J. M., Schultze, J. L. & Kolanus, W. Vav1 regulates MHCII expression in murine resting and activated B cells. Int. Immunol. 25, 307–317 (2013).

Böttcher, J. P., Schanz, O., Wohlleber, D., Abdullah, Z., Debey-Pascher, S., Staratschek-Jox, A., Höchst, B., Hegenbarth, S., Grell, J., Limmer, A., Atreya, I., Neurath, M. F., Busch, D. H., Schmitt, E., van Endert, P., Kolanus, W., Kurts, C., Schultze, J. L., Diehl, L. & Knolle, P. A. Liver-Primed Memory T Cells Generated under Noninflammatory Conditions Provide Anti-infectious Immunity. Cell Rep. 3, 779–795 (2013).

2012

Roth, W., Kumar, V., Beer, H.-D., Richter, M., Wohlenberg, C., Reuter, U., Thiering, S., Staratschek-Jox, A., Hofmann, A., Kreusch, F., Schultze, J. L., Vogl, T., Roth, J., Reichelt, J., Hausser, I. & Magin, T. M. Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18. . J. Cell Sci. 125, 5269 LP-5279 (2012).

Herzfeld, T., Nolte, D., Grznarova, M., Hofmann, A., Schultze, J. L. & Müller, U. X-linked dystonia parkinsonism syndrome (XDP, lubag): disease-specific sequence change DSC3 in TAF1/DYT3 affects genes in vesicular transport and dopamine metabolism. . Hum. Mol. Genet. 22, 941–951 (2013).

Beyer, M. Interleukin-2 treatment of tumor patients can expand regulatory T cells. . Oncoimmunology 1, 1181–1182 (2012).

Beyer, M., Mallmann, M. R., Xue, J., Staratschek-Jox, A., Vorholt, D., Krebs, W., Sommer, D., Sander, J., Mertens, C., Nino-Castro, A., Schmidt, S. V & Schultze, J. L.High-Resolution Transcriptome of Human Macrophages. . PLoS One 7, e45466 (2012).

Schmidt, S. V., Nino-Castro, A. C. & Schultze, J. L.Regulatory dendritic cells: There is more than just immune activation. Front. Immunol. 3, 1–17 (2012).