How the body protects itself from type 2 diabetes

Researchers at the DZNE and the University of Bonn discover a key role of the protein HPGD: New publication in the Journal "Immunity".

A specific group of white blood cells, termed "regulatory T cells", keeps the immune system in balance and suppresses its activity to protect the body against autoimmune diseases. Scientists at the German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn have now discovered a new mechanism by which regulatory T cells inhibit inflammation specifically in adipose tissue. This mechanism plays an important role in protecting against type 2 diabetes, as an overactive immune system in adipose tissue can promote insulin resistance and thus contribute to this metabolic disease. The study is now published in the journal “Immunity”.