2022

Yang X, Ali S, Zhao M, Richter L, Schäfer V, Schliehe-Diecks J, Frank M, Qi J, Larsen PK, Skerra J, Islam H, Wachtmeister T, Alter C, Huang A, Bhatia S, Köhrer K, Kirschning C, Weighardt H, Kalinke U, Kalscheuer R, Uhrberg M, Scheu S. Front Immunol. 2022 Apr 8. The Mycotoxin Beauvericin Exhibits Immunostimulatory Effects on Dendritic Cells via Activating the TLR4 Signaling Pathway. 13:856230. doi: 10.3389/fimmu.2022.856230 . eCollection 2022. PMID: 35464417 Free PMC article.

Faßbender S, Sondenheimer K, Majora M, Schindler J, Opitz FV, Pollet M, Haarmann-Stemmann T, Krutmann J, Weighardt H. J Invest Dermatol. 2022 Apr. Keratinocytes Counteract UVB-Induced Immunosuppression in Mice through HIF-1a Signaling. 142(4):1183-1193. doi: 10.1016/j.jid.2021.07.185 . Epub 2021 Sep 25. PMID: 34571000

2021

Erazo AB, Wang N, Standke L, Semeniuk AD, Fülle L, Cengiz SC, Thiem M, Weighardt H, Strugnell RA, Förster I. Immun Inflamm Dis. 2021 Sep;9(3). CCL17-expressing dendritic cells in the intestine are preferentially infected by Salmonella but CCL17 plays a redundant role in systemic dissemination. 891-904. doi: 10.1002/iid3.445. Epub 2021 May 4. PMID: 33945673 Free PMC article.

Novak N, Weighardt H, Valdelvira R, Izquierdo E, Förster I, Cabanillas B. Exp Dermatol. 2021 Nov;30(11). Herpes simplex virus 1 proteins can induce skin inflammation in an atopic dermatitis-like mouse model.1699-1704. doi: 10.1111/exd.14327. Epub 2021 Mar 22. PMID: 33751678

2020

Diehl KL, Vorac J, Hofmann K, Meiser P, Unterweger I, Kuerschner L, Weighardt H, Förster I, and Thiele C. 2020. Kupffer Cells Sense Free Fatty Acids and Regulate Hepatic Lipid Metabolism in High-Fat Diet and Inflammation. Cells. Oct 8;9(10):2258. doi: 10.3390/cells9102258

Taylor J, Sellin J, Kuerschner L, Krähl L, Majlesain Y, Förster I, Thiele C, Weighardt H*, and Weber E*. 2020. Generation of immune cell containing adipose organoids for in vitro analysis of immune metabolism. Sci Rep. Dec 3;10(1):21104. doi: 10.1038/s41598-020-78015-9 * equal contribution

Schanz O, Chijiiwa R, Cengiz SC, Majlesain Y, Weighardt H, Takeyama H, Förster I. Int J Mol Sci. 2020 Apr 30; Dietary AhR Ligands Regulate AhRR Expression in Intestinal Immune Cells and Intestinal Microbiota Composition. 21(9):3189. doi: 10.3390/ijms21093189 [Add to Citavi project by DOI] . PMID: 32366032 [Add to Citavi project by Pubmed ID] Free PMC article.

Merches K, Schiavi A, Weighardt H, Steinwachs S, Teichweyde N, Förster I, Hochrath K, Schumak B, Ventura N, Petzsch P, Köhrer K, Esser C. 2020. AHR Signaling Dampens Inflammatory Signature in Neonatal Skin γδ T Cells. Int J Mol Sci. 2020 Mar 24;21(6):2249. doi: 10.3390/ijms21062249 [Add to Citavi project by DOI] . PMID: 32213963 [Add to Citavi project by Pubmed ID] Free PMC article.

2019

Howe M, Bauer J, Schulze A, Kropp S, Locksley RM, Alferink J, Weighardt H, Scheu S. Int J Mol Sci. 2019 Sep 7; Production of IFNβ by Conventional Dendritic Cells after Stimulation with Viral Compounds and IFNβ-Independent IFNAR1-Signaling Pathways are Associated with Aggravation of Polymicrobial Sepsis. 20(18):4410. doi: 10.3390/ijms20184410 [Add to Citavi project by DOI] . PMID: 31500303 [Add to Citavi project by Pubmed ID] Free PMC article.

Cabanillas B, Weighardt H, Izquierdo E, Förster I, Novak N. 2020. IgE reactivity against herpes simplex virus 1 in patients with atopic dermatitis complicated by eczema herpeticum. . 75(1):226-229. doi: 10.1111/all.13986.

Schmidleithner L, Thabet Y, Schönfeld E, Köhne M, Sommer D, Abdullah Z, Sadlon T, Osei-Sarpong C, Subbaramaiah K, Copperi F, Haendler K, Varga T, Schanz O, Bourry S, Bassler K, Krebs W, Peters AE, Baumgart AK, Schneeweiss M, Klee K, Schmidt SV, Nüssing S, Sander J, Ohkura N, Waha A, Sparwasser T, Wunderlich FT, Förster I, Ulas T, Weighardt H, Sakaguchi S, Pfeifer A, Blüher M, Dannenberg AJ, Ferreirós N, Muglia LJ, Wickenhauser C, Barry SC, Schultze JL, Beyer M. Immunity. 2019 May 21; Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction. 50(5):1232-1248.e14. doi: 10.1016/j.immuni.2019.03.014 [Add to Citavi project by DOI] . Epub 2019 Apr 23. PMID: 31027998 [Add to Citavi project by Pubmed ID] Free article.

Wiszniewsky, A., Ritter, M., Krupp, V., Schulz, S., Arndts, K., Weighardt, H., Wanji, S., Hoerauf, A., Layland, L.E. 2019. The central adaptor molecule TRIF influences L. sigmodontis worm development. Parasitol. Res. 2019 Jan 15, Epub ahead of print.

2018

Fülle, L., Offermann, N., Hansen, J.N., Breithausen, B., Erazo, A.B., Schanz, O., Radau, L., Gondorf, F., Knöpper, K., Alferink, J., Abdullah, Z., Neumann, H., Weighardt, H., Henneberger, C., Halle, A., Förster, I. 2018. CCL17 exerts a neuroimmune modulatory function and is expressed in hippocampal neurons. Glia. 2018 Oct: 66(10): 2246 - 2261.

Fülle, L., Steiner, N., Funke, M., Gondorf, F., Pfeiffer, F., Siegl, J., Opitz, F.V., Hassel, S.K., Erazo, A.B., Schanz, O., Stunden, H.J., Blank, M., Gröber, C., Händler, K., Beyer, M., Weighardt, H., Latz, E., Schultze, J.L., Mayer, G., Förster, I. 2018 RNA aptamers recognizing murine CCL17 inhibit T cell chemotaxis and reduce contact hypersensitivity in vivo. Mol.Ther. 2018 Jan 3; 26(1): 95 - 104.

2017

Pillaiyar, T., Köse, M., Sylvester, K., Weighardt, H., Thimm, D., Borges, G., Förster, I., von Kügelgen, I., Müller, C.E. 2017. Diindolylmethane derivatives: Potent agonists of the immunostimulatory orphan G protein-coupled receptor GPR84. J Med Chem 2017, May 11,  60 (9), 3636 - 3655.  

Fassbender, S., Opitz, F.V., Johnen, S., Förster, I., Weighardt, H. 2017. MyD88 contributes to Staphylococcal Enterotoxin B-triggered atopic dermatitis-like skin inflammation in mice. 2017. J Invest Dermatol. S0022-202X (17) 31436 - 31437.

Koch, S., Stroisch, T.J., Vorac, J., Herrmann, N., Leib, N., Schnautz, S., Kirins, H., Förster, I., Weighardt, H., Bieber, T. 2017. AhR mediates an anti-inflammatory feed-back mechanism in human Langerhans cells involving FceRI and IDO. Allgery. 2017, Nov, 72 (11): 1686 - 1693..

2016

Haas, K., Weighardt, H., Deenen, R., Köhrer, K., Clausen, B., Zahner, S., Boukamp, P., Bloch, W., Krutmann, J., Esser, C. Aryl hdrocarbon receptor in keratinocytes is essential for murine skin barrier integrity. 2016. J Invest Dermatol 2016, Nov, 136(11): 2260 - 2269.

Brandstätter, O., Schanz, O., Vorac, J., König, J., Mori, T., Maruyama, T., Korkowski, M., Haarmann-Stemmann, T., von Smolinski, D., Schultze, J.L., Abel J., Esser, C., Takeyama, H., Weighardt, H., Förster, I. 2016. Balancing intestinal and systemic inflammation through cell type-specific expression of the aryl hydrocarbon receptor repressor. Sci Rep. 2016, May 17, 6:26091.

Didovic, S., Opitz, F.V., Holzmann. B., Förster, I., Weighardt, H. 2016. Requirement of MyD88 signaling in keratinocytes for Langerhans cell migration and initiation of atopic dermatitis-like symptoms in mice. Eur J Immunol. 46 (4), 981 - 992.

2015

Kroker, M., Sydlik, U., Autengruber, A., Cavelius, C., Weighardt, H., Kraegeloh, A., Unfried, K. 2015. Preventing carbon nanoparticle-induced lung inflammation reduces antigen-specific sensitization and subsequent allergic reactions in a mouse model. Part Fibre Toxicol. Jul 4: 12:20. doi: 10.1186/s12989-015-0093-5.

Weighardt, H. and Förster, I. 2015. Bcl-3 puts the brakes on contact hypersensitivity. Eur J Immunol. 45 (4), 971 - 974.

Sommer, D., Peters, A.E., Wirtz, T., Mai, M., Ackermann, J., Thabet, Y., Schmidt, J., Weighardt, H., Wunderlich, F.T., Degen, J., Schultze, J.L., Beyer, M. 2015. Corrigendum: Efficient genome engineering by targeted homologous recombination in mouse embryos using transcription activator-like effector nucleases. Nat. Commun. Feb. 20; 6:5927. doi:10.1038/ncomms6927.

2014

MacPherson, L., Ahmed, S., Tamblyn, L., Krutmann, J., Förster, I., Weighardt, H. and Matthews, J. 2014. Aryl hydrocarbon receptor repressor and TiPARP (ARTD14) use similar, but also distinct mechanisms to repress aryl hydrocarbon receptor signaling. Int. J. Mol.Sci. 15, 7939 - 7957.

Bald, T., Quast, T., Landsberg, J., Rogava, M., Glodde, N., Lopez-Ramos, D., Kohlmeyer, J., Riesenberg, S., van den Boorn-Konijnenberg, D., Hömig-Hölzel, C., Reuten, R., Schadow, B., Weighardt, H., Wenzel, D., Helfrich, I., Schadendorf, D., Bloch, W., Bianchi, M.E., Lugassy, C., Barnhill, R.L., Koch, M., Fleischmann, B.K., Förster, I., Kastenmüller, W., Kolanus, W., Hölzel, M., Gaffal, E. and Tüting, T. 2014. Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma. Nature 507, 109 - 113.

Globisch, T., Steiner, N., Fülle, L., Lukacs-Kornek, V., Degrandi, D., Dresing, P., Alfernik, J., Lang, R., Pfeffer, K., Beyer, M., Weighardt, H., Kurts, C., Ulas, T., Schulze, J.L. and Förster, I. 2014. Cytokine-dependent regulation of dendritic cell differentiation in the splenic microenvironment. Eur. J. Immunol. 44, 500 - 510.

2013

Tigges, J.*, Weighardt,H.*, Wolff,S., Gotz,C., Förster,I., Kohne,Z., Huebenthal, U.,Merk,H.F., Abel,J.,Haarmann-Stemmann,T., Krutmann,J., and Fritsche,E. 2013. Aryl Hydrocarbon Receptor Repressor (AhRR) Function Revisited: Repression of CYP1 Activity in Human Skin Fibroblasts Is Not Related to AhRR Expression. J.Invest Dermatol. Jan;133(1):87-96
(*equal contribution)

Wohn, C., J. L. Ober-Blobaum, S. Haak, S. Pantelyushin, C. Cheong, S. P. Zahner, S. Onderwater, M. Kant, H. Weighardt, B. Holzmann, B. Reizis, B. Becher, E. P. Prens, and B. E. Clausen. 2013. Langerin(neg) conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice. Proc. Natl. Acad. Sci. U. S. A 110: 10723-10728.

Wilhelmi, V., U. Fischer, H. Weighardt, K. Schulze-Osthoff, C. Nickel, B. Stahlmecke, T. A. Kuhlbusch, A. M. Scherbart, C. Esser, R. P. Schins, and C. Albrecht. 2013. Zinc oxide nanoparticles induce necrosis and apoptosis in macrophages in a p47phox- and Nrf2-independent manner. PLoS. One. 8: e65704.

Esser, C., I. Bargen, H. Weighardt, T. Haarmann-Stemmann, and J. Krutmann. 2013. Functions of the aryl hydrocarbon receptor in the skin. Semin.Immunopathol. 35: 677-691.

2012

Kohler, T., Reizis,B., Johnson,R.S., Weighardt,H., and Förster,I.. 2012. Influence of hypoxia-inducible factor 1alpha on dendritic cell differentiation and migration. Eur. J. Immunol. 42: 1226-1236.

Gais, P., Reim,D., Jusek,G., Rossmann-Bloeck,T., Weighardt,H., Pfeffer,K., Altmayr,F., Janssen,K.P., and Holzmann,B. 2012. Cutting edge: Divergent cell-specific functions of MyD88 for inflammatory responses and organ injury in septic peritonitis. J. Immunol. 188: 5833-5837.

2010

Gais,P., Tiedje,C., Altmayr,F., Gaestel,M., Weighardt,H., and Holzmann,B. 2010. TRIF Signaling Stimulates Translation of TNF-{alpha} mRNA via Prolonged Activation of MK2. J.Immunol., 184(10):5842-8.

Chmill,S., Kadow,S., Winter,M., Weighardt,H., and Esser,C. 2010 2,3,7,8-Tetrachlorodibenzo-P-Dioxin Impairs Stable Establishment of Oral Tolerance in Mice. Toxicol.Sci. 118(1):98-10.

Hammer,M., Echtenachter,B., Weighardt,H., Jozefowski,K., Rose-John,S., Mannel,D.N., Holzmann,B., and Lang,R.2010 Increased inflammation and lethality of Dusp1(-/-) mice in polymicrobial peritonitis models. Immunology;131(3):395-404.

2009

Reim, D., K. Westenfelder, S. Kaiser-Moore, S. Schlautkotter, B. Holzmann, and H. Weighardt. 2009. Role of T cells for cytokine production and outcome in a model of acute septic peritonitis. Shock 31:245-250.

Assfalg, V., N. Huser, D. Reim, S. Kaiser-Moore, T. Rossmann-Bloeck, H.Weighardt, A. R. Novotny, M. J. Stangl, B. Holzmann, and K. L. Emmanuel. 2009. Combined Immunosuppressive and Antibiotic Therapy Improves Bacterial Clearance and Survival of Polymicrobial Septic Peritonitis. Shock 33:155-61.

2008

Lochner, M., K. Kastenmuller, M. Neuenhahn, H. Weighardt, D. H. Busch, W. Reindl, and I. Forster. 2008. Decreased susceptibility of mice to infection with Listeria monocytogenes in the absence of interleukin-18. Infect. Immun. 76:3881-3890.

2007

Weber, G. F., S. Schlautkotter, S. Kaiser-Moore, F. Altmayr, B. Holzmann, and H.Weighardt. 2007. Inhibition of interleukin-22 attenuates bacterial load and organ failure during acute polymicrobial sepsis. Infect. Immun. 75:1690-1697.

Novotny, A. R., K. Emmanuel, S. Maier, A. Westerholt, H. Weighardt, J. Stadler, H. Bartels, M. Schwaiger, J. R. Siewert, B. Holzmann, and C. D. Heidecke. 2007. Cytochrome P450 activity mirrors nitric oxide levels in postoperative sepsis: predictive indicators of lethal outcome. Surgery 141:376-384.

Novotny, A., K. Emmanuel, E. Matevossian, M. Kriner, K. Ulm, H. Bartels, B. Holzmann, H. Weighardt*, and J. R. Siewert*. 2007. Use of procalcitonin for early prediction of lethal outcome of postoperative sepsis. Am. J. Surg. 194:35-39.
(*equal contribution)

Weighardt, H., and B. Holzmann. 2007. Role of Toll-like receptor responses for sepsis pathogenesis. Immunobiology 212:715-722.

Schroder, K., M. Spille, A. Pilz, J. Lattin, K. A. Bode, K. M. Irvine, A. D. Burrows, T. Ravasi, H. Weighardt, K. J. Stacey, T. Decker, D. A. Hume, A. H. Dalpke, and M. J. Sweet. 2007. Differential effects of CpG DNA on IFN-beta induction and STAT1 activation in murine macrophages versus dendritic cells: alternatively activated STAT1 negatively regulates TLR signaling in macrophages. J. Immunol. 179:3495-3503.

2006

Weighardt, H., J. Mages, G. Jusek, S. Kaiser-Moore, R. Lang, and B. Holzmann. 2006. Organ-specific role of MyD88 for gene regulation during polymicrobial peritonitis. Infect. Immun. 74:3618-3632.

Novotny, A. R., K. Emmanuel, K. Ulm, H. Bartels, J. R. Siewert, H. Weighardt*, and B. Holzmann*. 2006. Blood interleukin 12 as preoperative predictor of fatal postoperative sepsis after neoadjuvant radiochemotherapy. Br. J. Surg. 93:1283-1289.
(*equal contribution)

von, M. F., M. Schaefer, H. Weighardt, S. Bauer, C. J. Kirschning, H. Wagner, and T. Sparwasser. 2006. Toll-like receptor 9 contributes to recognition of Mycobacterium bovis Bacillus Calmette-Guerin by Flt3-ligand generated dendritic cells. Immunobiology 211:557-565.

Weighardt, H., S. Kaiser-Moore, S. Schlautkotter, T. Rossmann-Bloeck, U. Schleicher, C. Bogdan, and B. Holzmann. 2006. Type I IFN modulates host defense and late hyperinflammation in septic peritonitis. J. Immunol. 177:5623-5630.

Weber, G. F., F. C. Gaertner, W. Erl, K. P. Janssen, B. Blechert, B. Holzmann, H. Weighardt*, and M. Essler*. 2006. IL-22-mediated tumor growth reduction correlates with inhibition of ERK1/2 and AKT phosphorylation and induction of cell cycle arrest in the G2-M phase. J. Immunol. 177:8266-8272.
(*equal contribution)

2005

Feterowski, C., A. Novotny, S. Kaiser-Moore, P. F. Muhlradt, T. Rossmann-Bloeck, M. Rump, B. Holzmann, and H. Weighardt. 2005. Attenuated pathogenesis of polymicrobial peritonitis in mice after TLR2 agonist pre-treatment involves ST2 up-regulation. Int. Immunol. 17:1035-1046.

Emmanuel,K., Weighardt,H., Bartels,H., Siewert,J.R., and Holzmann,B., Current and future concepts of abdominal sepsis. World J Surg. 2005. 29: 3-9.

2004

Weighardt, H., G. Jusek, J. Mages, R. Lang, K. Hoebe, B. Beutler, and B. Holzmann. 2004. Identification of a TLR4- and TRIF-dependent activation program of dendritic cells . Eur. J. Immunol. 34:558-564.

Ruckdeschel, K., G. Pfaffinger, R. Haase, A. Sing, H. Weighardt, G. Hacker, B. Holzmann, and J. Heesemann. 2004. Signaling of apoptosis through TLRs critically involves toll/IL-1 receptor domain-containing adapter inducing IFN-beta, but not MyD88, in bacteria-infected murine macrophages. J. Immunol. 173:3320-3328.

Feterowski, C., M. Mack, H. Weighardt, B. Bartsch, S. Kaiser-Moore, and B. Holzmann. 2004. CC chemokine receptor 2 regulates leukocyte recruitment and IL-10 production during acute polymicrobial sepsis. Eur. J. Immunol. 34:3664-3673.

2003

Feterowski,C., Emmanuilidis,K., Miethke,T., Gerauer,K., Rump,M., Ulm,K., Holzmann,B., and Weighardt,H., Effects of functional Toll-like receptor-4 mutations on the immune response to human and experimental sepsis. Immunology 2003. 109: 426-431.

Holzmann,B., Weighardt,H., and Heidecke,C.D., [Receptors and signal proteins of the innate immune system as new targets in sepsis therapy. Reprogramming of the immune response]. Chirurg 2003. 74: 61-64.

2002

Heidecke,C.D., Weighardt,H., Feith,M., Fink,U., Zimmermann,F., Stein,H.J., Siewert,J.R., and Holzmann,B., Neoadjuvant treatment of esophageal cancer: Immunosuppression following combined radiochemotherapy. Surgery 2002. 132: 495-501.

Weighardt,H., Heidecke,C.D., Westerholt,A., Emmanuilidis,K., Maier,S., Veit,M., Gerauer,K., Matevossian,E., Ulm,K., Siewert,J.R., and Holzmann,B., Impaired monocyte IL-12 production before surgery as a predictive factor for the lethal outcome of postoperative sepsis. Ann.Surg. 2002. 235: 560-567.

Weighardt,H., Kaiser-Moore,S., Vabulas,R.M., Kirschning,C.J., Wagner,H., and Holzmann,B., Cutting edge: myeloid differentiation factor 88 deficiency improves resistance against sepsis caused by polymicrobial infection. J Immunol 2002. 169: 2823-2827.

Beer,S., Weighardt,H., Emmanuilidis,K., Harzenetter,M.D., Matevossian,E., Heidecke,C.D., Bartels,H., Siewert,J.R., and Holzmann,B., Systemic neuropeptide levels as predictive indicators for lethal outcome in patients with postoperative sepsis. Crit Care Med. 2002. 30: 1794-1798.

Emmanuilidis,K., Weighardt,H., Matevossian,E., Heidecke,C.D., Ulm,K., Bartels,H., Siewert,J.R., and Holzmann,B., Differential regulation of systemic IL-18 and IL-12 release during postoperative sepsis: high serum IL-18 as an early predictive indicator of lethal outcome. Shock 2002. 18: 301-305.

2001

Emmanuilidis,K., Weighardt,H., Maier,S., Gerauer,K., Fleischmann,T., Zheng,X.X., Hancock,W.W., Holzmann,B., and Heidecke,C.D., Critical role of Kupffer cell-derived IL-10 for host defense in septic peritonitis. J Immunol 2001. 167: 3919-3927.

Feterowski,C., Weighardt,H., Emmanuilidis,K., Hartung,T., and Holzmann,B., Immune protection against septic peritonitis in endotoxin-primed mice is related to reduced neutrophil apoptosis. Eur.J Immunol 2001. 31: 1268-1277.

2000

Weighardt,H., Heidecke,C.D., Emmanuilidis,K., Maier,S., Bartels,H., Siewert,J.R., and Holzmann,B., Sepsis after major visceral surgery is associated with sustained and interferon-gamma-resistant defects of monocyte cytokine production. Surgery 2000. 127: 309-315.

Heidecke,C.D., Weighardt,H., Hensler,T., Bartels,H., and Holzmann,B., [Immune paralysis of T-lymphocytes and monocytes in postoperative abdominal sepsis. Correlation of immune function with survival]. Chirurg 2000. 71: 159-165.

1999

Simins,A.B., Weighardt,H., Weidner,K.M., Weidle,U.H., and Holzmann,B., Functional cloning of ARM-1, an adhesion-regulating molecule upregulated in metastatic tumor cells. Clin.Exp.Metastasis 1999. 17: 641-648.

Heidecke,C.D., Hensler,T., Weighardt,H., Zantl,N., Wagner,H., Siewert,J.R., and Holzmann,B., Selective defects of T lymphocyte function in patients with lethal intraabdominal infection. Am.J Surg. 1999. 178: 288-292.

1994

Engelhardt, B., H. Gorlach, W. Risau, and H. Wekerle. 1994. Lysis of rat brain microvascular endothelial cells mediated by resting but not activated MBP-specific CD4+ T cell lines. J. Neuroimmunol. 55:69-80.