Selected list of Publications
Embgenbroich M, van der Zande HJP, Hussaarts L, Schulte-Schrepping J, Pelgrom LR, García-Tardón N, Schlautmann L, Stoetzel I, Händler K, Lambooij JM, Zawistowska-Deniziak A, Hoving L, de Ruiter K, Wijngaarden MA, Pijl H, Willems van Dijk K, Everts B, van Harmelen V, Yazdanbakhsh M, Schultze JL, Guigas B, Burgdorf S. Soluble mannose receptor induces proinflammatory macrophage activation and metaflammation. (2021) Proc Natl Acad Sci U S A.;118(31):e2103304118. doi: 10.1073/pnas.2103304118
van der Zande HJP, Nitsche D, Schlautmann L, Guigas B, Burgdorf S. The Mannose Receptor: From Endocytic Receptor and Biomarker to Regulator of (Meta)Inflammation. (2021) Front Immunol. Oct 14;12:765034. doi: 10.3389/fimmu.2021.765034
Schuette V, Embgenbroich M, Ulas T, Welz M, Schulte-Schrepping J, Draffehn AM, Quast T, Koch K, Nehring M, König J, Zweynert A, Harms FL, Steiner N, Limmer A, Förster I, Berberich Siebelt F, Knolle PA, Wohlleber D, Kolanus W, Beyer M, Schultze JL, Burgdorf S. Mannose receptor induces T-cell tolerance via inhibition of CD45 and up-regulation of CTLA-4. (2016) Proc Natl Acad Sci U S A.;113(38):10649-54. doi: 10.1073/pnas.1605885113
Zehner M, Marschall AL, Bos E, Schloetel JG, Kreer C, Fehrenschild D, Limmer A, Ossendorp F, Lang T, Koster AJ, Dübel S, Burgdorf S. The translocon protein Sec61 mediates antigen transport from endosomes in the cytosol for cross-presentation to CD8(+) T cells. (2015) Immunity;42(5):850-63. doi: 10.1016/j.immuni.2015.04.008
Schuette, V., Burgdorf, S. The ins-and-outs of endosomal antigens for cross-presentation. (2014) Curr Opin Immunol. DOI 10.1016/j.coi.2013.11.001
Zehner, M. and Burgdorf, S. Regulation of antigen transport into the cytosol for cross-presentation by ubiquitination of the Mannose Receptor (2013). Mol Immunol, 55: 146-148.
Chasan AI, Beyer B, Kurts C, Burgdorf S. (2013). Isolation of a specialized, antigen-loaded early endosomal subpopulation by flow cytometry. Methods Mol Biol, 960: 379-388.
Zehner, M., Rauen, J., Chasan, A.I., Embgenbroich, M., Camps, M.G., Kaden, S., Haas, A., Kurts, C., Endl, E., Beyer, M., Gröne, H.J., Ossendorp, F. and Burgdorf, S. (2012) Intraendosomal flow cytometry: A novel approach to analyze the protein composition of antigen-loaded endosomes. Eur J Immunol, 42: 1-4.
Everts, B., Hussaarts, l., Driessen, N.N., Meevissen, M.H.J., Schramm, G., van der Ham, A.J., van der Hoeven, B., Burgdorf, S., Mohrs, M., Pearce, E.J., Hokke, C.H., Haas, H., Smits, H.H. and Yazdanbakhsh, M. (2012) Schistosome‐derived omega‐1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor. J Exp Med, 209: 1753-1767.
Zehner, M., Chasan, A.I., Schuette, V., Embgenbroich, M., Quast, T., Kolanus, W., Burgdorf S. (2011) Mannose receptor polyubiquitination regulates endosomal recruitment of p97 and cytosolic antigen translocation for cross-presentation. Proc Natl Acad Sci USA, 108(24): 9933-9938.
Burgdorf, S., Schuette, V., Semmling, V., Hochheiser, K., Lukacs-Kornek, V., Knolle, P.A. and Kurts C (2010) Steady-state cross-presentation of OVA is mannose receptor-dependent but inhibitable by collagen fragments. Proc Natl Acad Sci USA, 107(13):E48-9.
Klotz, L., Hucke, S., Thimm, D., Schultze, J., Edenhofer, F., Kurts, C., Klockgether, T., Knolle, P. and Burgdorf, S. (2009) Increased antigen cross-presentation but impaired cross-priming after activation of PPARg is mediated by up-regulation of B7H1. J Immunol, 183(1):129-136.
Klotz, L., Burgdorf, S., Dani, I., Saijo, K., Flossdorf, J., Hucke, S., Alferink, J., Novak, N., Beyer, M., Mayer, G., Langhans, B., Klockgether, T., Waisman, A., Eberl, G., Schultze, J., Famulok, M., Kolanus, W., Glass, C., Kurts C. and Knolle, P.A, (2009) The nuclear receptor PPARg selectively controls TH17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity. J Exp Med, 206:2079-2089.
Burgdorf, S., Schölz, C., Kautz, A., Tampé, R. and Kurts, C. (2008) Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation. Nat Immunol, 9(5): 558-566.
Burgdorf, S. and Kurts, C. (2008) Endocytosis mechanisms and the cell biology of antigen-presentation. Curr Opin Immunol, 20(1):89-95.
Burgdorf, S., Kautz, A., Böhnert, V., Knolle, P.A. and Kurts C. (2007). Distinct antigen uptake and intracellular routing mechanisms for CD4 or CD8 T cell activation. Science, 316(5824):612-6.
Burgdorf, S., Lukacs-Kornek, V. and Kurts, C. (2006). The mannose receptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation. J Immunol, 176(11):6770-6.
Burgdorf, S., Leister, P. and Scheidtmann, K.H. (2004). TSG101 interacts with AATF and enhances AR-mediated transcription by promoting its mono-ubiquitination. J Biol Chem, 279(17):17524-34.