Ausgewählte Publikationen des LIMES-Instituts

Eine Gesamtübersicht über die Publikationen der vergangenen Jahre finden Sie in unserem Broschüren-Downloadbereich.

2022

Barret DCA, Schertler GFX, Kaupp UB, Marino J. The structure of the native CNGA1/CNGB1 CNG channel from bovine retinal rods. Nat Struct Mol Biol. 2022 Jan;29(1):32-39. doi: 10.1038/s41594-021-00700-8. Epub 2021 Dec 30. PMID: 34969975

Bonaguro L, Schulte-Schrepping J, Ulas T, Aschenbrenner AC, Beyer M, Schultze JL. A guide to systems-level immunomics. Nat Immunol. 2022 Oct;23(10):1412-1423. doi: 10.1038/s41590-022-01309-9. Epub 2022 Sep 22. PMID: 36138185 Review.

Carraro C, Bonaguro L, Schulte-Schrepping J, Horne A, Oestreich M, Warnat-Herresthal S, Helbing T, De Franco M, Haendler K, Mukherjee S, Ulas T, Gandin V, Goettlich R, Aschenbrenner AC, Schultze JL, Gatto B. Decoding mechanism of action and sensitivity to drug candidates from integrated transcriptome and chromatin state. Elife. 2022 Aug 31;11:e78012. doi: 10.7554/eLife.78012. PMID: 36043458 Free PMC article.

Dietler J, Gelfert R, Kaiser J, Borin V, Renzl C, Pilsl S, Ranzani AT, García de Fuentes A, Gleichmann T, Diensthuber RP, Weyand M, Mayer G, Schapiro I, Möglich A. Signal transduction in light-oxygen-voltage receptors lacking the active-site glutamine. Nat Commun. 2022 May 12;13(1):2618. doi: 10.1038/s41467-022-30252-4. PMID: 35552382 Free PMC article. 

Duy PQ, Weise SC, Marini C, Li XJ, Liang D, Dahl PJ, Ma S, Spajic A, Dong W, Juusola J, Kiziltug E, Kundishora AJ, Koundal S, Pedram MZ, Torres-Fernández LA, Händler K, De Domenico E, Becker M, Ulas T, Juranek SA, Cuevas E, Hao LT, Jux B, Sousa AMM, Liu F, Kim SK, Li M, Yang Y, Takeo Y, Duque A, Nelson-Williams C, Ha Y, Selvaganesan K, Robert SM, Singh AK, Allington G, Furey CG, Timberlake AT, Reeves BC, Smith H, Dunbar A, DeSpenza T Jr, Goto J, Marlier A, Moreno-De-Luca A, Yu X, Butler WE, Carter BS, Lake EMR, Constable RT, Rakic P, Lin H, Deniz E, Benveniste H, Malvankar NS, Estrada-Veras JI, Walsh CA, Alper SL, Schultze JL, Paeschke K, Doetzlhofer A, Wulczyn FG, Jin SC, Lifton RP, Sestan N, Kolanus W, Kahle KT. Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus. Nat Neurosci. 2022 Apr;25(4):458-473. doi: 10.1038/s41593-022-01043-3. Epub 2022 Apr 4. PMID: 35379995 Free PMC article.

Faßbender S, Sondenheimer K, Majora M, Schindler J, Opitz FV, Pollet M, Haarmann-Stemmann T, Krutmann J, Weighardt H. Keratinocytes Counteract UVB-Induced Immunosuppression in Mice through HIF-1a Signaling. J Invest Dermatol. 2022 Apr;142(4):1183-1193. doi: 10.1016/j.jid.2021.07.185. Epub 2021 Sep 25. PMID: 34571000

Ferreira AV, Uijen RF, Bulut O, de Jonge MI, Domínguez-Andrés J, Netea MG. Limited role of the spleen in a mouse model of trained immunity: Impact on neutrophilia. J Leukoc Biol. 2022 Jan;111(1):9-17. doi: 10.1002/JLB.4HI0221-106RR. Epub 2021 Oct 1. PMID: 34596266 Free PMC article.

Imambocus BN, Zhou F, Formozov A, Wittich A, Tenedini FM, Hu C, Sauter K, Macarenhas Varela E, Herédia F, Casimiro AP, Macedo A, Schlegel P, Yang CH, Miguel-Aliaga I, Wiegert JS, Pankratz MJ, Gontijo AM, Cardona A, Soba P. A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae. Curr Biol. 2022 Jan 10;32(1):149-163.e8. doi: 10.1016/j.cub.2021.10.069. Epub 2021 Nov 18. PMID: 34798050

Karagiannis F, Peukert K, Surace L, Michla M, Nikolka F, Fox M, Weiss P, Feuerborn C, Maier P, Schulz S, Al B, Seeliger B, Welte T, David S, Grondman I, de Nooijer AH, Pickkers P, Kleiner JL, Berger MM, Brenner T, Putensen C; Bonn COVIMMUNE Consortium; Kato H, Garbi N, Netea MG, Hiller K, Placek K, Bode C, Wilhelm C. Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19. Nature. 2022 Sep;609(7928):801-807. doi: 10.1038/s41586-022-05128-8. Epub 2022 Jul 28. PMID: 35901960 Free PMC article.

Laufkötter O, Hu H, Miljković F, Bajorath J. Structure- and Similarity-Based Survey of Allosteric Kinase Inhibitors, Activators, and Closely Related Compounds. J Med Chem. 2022 Jan 27;65(2):922-934. doi: 10.1021/acs.jmedchem.0c02076. Epub 2021 Jan 21. PMID: 33476146 Review.

Paradis M, Kucharowski N, Edwards Faret G, Maya Palacios SJ, Meyer C, Stümpges B, Jamitzky I, Kalinowski J, Thiele C, Bauer R, Paululat A, Sellin J, Bülow MH. The ER protein Creld regulates ER-mitochondria contact dynamics and respiratory complex 1 activity. Sci Adv. 2022 Jul 22;8(29):eabo0155. doi: 10.1126/sciadv.abo0155. Epub 2022 Jul 22. PMID: 35867795 Free PMC article.

Quast T, Zölzer K, Guu D, Alvarez L, Küsters C, Kiermaier E, Kaupp UB, Kolanus W. A Stable Chemokine Gradient Controls Directional Persistence of Migrating Dendritic Cells. Front Cell Dev Biol. 2022 Aug 9;10:943041. doi: 10.3389/fcell.2022.943041. eCollection 2022. PMID: 36016652 Free PMC article.

Weier AK, Homrich M, Ebbinghaus S, Juda P, Miková E, Hauschild R, Zhang L, Quast T, Mass E, Schlitzer A, Kolanus W, Burgdorf S, Gruß OJ, Hons M, Wieser S, Kiermaier E. Multiple centrosomes enhance migration and immune cell effector functions of mature dendritic cells. J Cell Biol. 2022 Dec 5;221(12):e202107134. doi: 10.1083/jcb.202107134. Epub 2022 Oct 10. PMID: 36214847

2021

Divangahi M, Aaby P, Khader SA, Barreiro LB, Bekkering S, Chavakis T, van Crevel R, Curtis N, DiNardo AR, Dominguez-Andres J, Duivenwoorden R, Fanucchi S, Fayad Z, Fuchs E, Hamon M, Jeffrey KL, Khan N, Joosten LAB, Kaufmann E, Latz E, Matarese G, van der Meer JWM, Mhlanga M, Moorlag SJCFM, Mulder WJM, Naik S, Novakovic B, O’Neill L, Ochando J, Ozato K, Riksen NP, Sauerwein R, Sherwood ER, Schlitzer A, Schultze JL, Sieweke MH, Benn CS, Stunnenberg H, Sun J, van de Veerdonk FL, Weis S, Williams DL, Xavier R, Netea MG. Trained immunity, tolerance, priming and differentiation: distinct immunological processes. Nat Immunol. 2021 Jan;22(1):2-6. doi: 10.1038/s41590-020-00845-6. PMID: 33293712 No abstract available.

Embgenbroich M, van der Zande HJP, Hussaarts L, Schulte-Schrepping J, Pelgrom LR, García-Tardón N, Schlautmann L, Stoetzel I, Händler K, Lambooij JM, Zawistowska-Deniziak A, Hoving L, de Ruiter K, Wijngaarden M, Pijl H, Willems van Dijk K, Everts B, van Harmelen V, Yazdanbakhsh M, Schultze JL, Guigas B, Burgdorf S. Soluble mannose receptor induces proinflammatory macrophage activation and metaflammation. Proc Natl Acad Sci U S A. 2021 Aug 3;118(31):e2103304118. doi: 10.1073/pnas.2103304118. PMID: 34326259

Hückesfeld S, Schlegel P, Miroschnikow A, Schoofs A, Zinke I, Haubrich AN, Schneider-Mizell CM, Truman JW, Fetter RD, Cardona A, Pankratz MJ. Unveiling the sensory and interneuronal pathways of the neuroendocrine connectome in Drosophila. Elife. 2021 Jun 4;10:e65745. doi: 10.7554/eLife.65745. PMID: 34085637 Free PMC article.

Izadifar A, Courchet J, Virga DM, Verreet T, Hamilton S, Ayaz D, Misbaer A, Vandenbogaerde S, Monteiro L, Petrovic M, Sachse S, Yan B, Erfurth ML, Dascenco D, Kise Y, Yan J, Edwards-Faret G, Lewis T, Polleux F, Schmucker D. Axon morphogenesis and maintenance require an evolutionary conserved safeguard function of Wnk kinases antagonizing Sarm and Axed. Neuron. 2021 Sep 15;109(18):2864-2883.e8. doi: 10.1016/j.neuron.2021.07.006. Epub 2021 Aug 11. PMID: 34384519

Katzmarski N, Domínguez-Andrés J, Cirovic B, Renieris G, Ciarlo E, Le Roy D, Lepikhov K, Kattler K, Gasparoni G, Händler K, Theis H, Beyer M, van der Meer JWM, Joosten LAB, Walter J, Schultze JL, Roger T, Giamarellos-Bourboulis EJ, Schlitzer A, Netea MG. Transmission of trained immunity and heterologous resistance to infections across generations. Nat Immunol. 2021 Nov;22(11):1382-1390. doi: 10.1038/s41590-021-01052-7. Epub 2021 Oct 18. PMID: 34663978

Kern P, Balzer NR, Blank N, Cygon C, Wunderling K, Bender F, Frolov A, Sowa JP, Bonaguro L, Ulas T, Homrich M, Kiermaier E, Thiele C, Schultze JL, Canbay A, Bauer R, Mass E. Creld2 function during unfolded protein response is essential for liver metabolism homeostasis. FASEB J. 2021 Oct;35(10):e21939. doi: 10.1096/fj.202002713RR.PMID: 34549824

Krämer B, Knoll R, Bonaguro L, ToVinh M, Raabe J, Astaburuaga-García R, Schulte-Schrepping J, Kaiser KM, Rieke GJ, Bischoff J, Monin MB, Hoffmeister C, Schlabe S, De Domenico E, Reusch N, Händler K, Reynolds G, Blüthgen N, Hack G, Finnemann C, Nischalke HD, Strassburg CP, Stephenson E, Su Y, Gardner L, Yuan D, Chen D, Goldman J, Rosenstiel P, Schmidt SV, Latz E, Hrusovsky K, Ball AJ, Johnson JM, Koenig PA, Schmidt FI, Haniffa M, Heath JR, Kümmerer BM, Keitel V, Jensen B, Stubbemann P, Kurth F, Sander LE, Sawitzki B; Deutsche COVID-19 OMICS Initiative (DeCOI), Aschenbrenner AC, Schultze JL, Nattermann J. Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19. Immunity. 2021 Nov 9;54(11):2650-2669.e14. doi: 10.1016/j.immuni.2021.09.002. Epub 2021 Sep 4. PMID: 34592166 Free PMC article.

Müller P, Sahlbach M, Gasper S, Mayer G, Müller J, Pötzsch B, Heckel A. Controlling Coagulation in Blood with Red Light. Angew Chem Int Ed Engl. 2021 Oct 4;60(41):22441-22446. doi: 10.1002/anie.202108468. Epub 2021 Aug 31. PMID: 34293228 Free PMC article.

Warnat-Herresthal S, Schultze H, Shastry KL, Manamohan S, Mukherjee S, Garg V, Sarveswara R, Händler K, Pickkers P, Aziz NA, Ktena S, Tran F, Bitzer M, Ossowski S, Casadei N, Herr C, Petersheim D, Behrends U, Kern F, Fehlmann T, Schommers P, Lehmann C, Augustin M, Rybniker J, Altmüller J, Mishra N, Bernardes JP, Krämer B, Bonaguro L, Schulte-Schrepping J, De Domenico E, Siever C, Kraut M, Desai M, Monnet B, Saridaki M, Siegel CM, Drews A, Nuesch-Germano M, Theis H, Heyckendorf J, Schreiber S, Kim-Hellmuth S; COVID-19 Aachen Study (COVAS), Nattermann J, Skowasch D, Kurth I, Keller A, Bals R, Nürnberg P, Rieß O, Rosenstiel P, Netea MG, Theis F, Mukherjee S, Backes M, Aschenbrenner AC, Ulas T; Deutsche COVID-19 Omics Initiative (DeCOI), Breteler MMB, Giamarellos-Bourboulis EJ, Kox M, Becker M, Cheran S, Woodacre MS, Goh EL, Schultze JL. Swarm Learning for decentralized and confidential clinical machine learning. Nature. 2021 Jun;594(7862):265-270. doi: 10.1038/s41586-021-03583-3. Epub 2021 May 26. PMID: 34040261 Free PMC article.

Wunderling K, Leopold C, Jamitzky I, Yaghmour M, Zink F, Kratky D, Thiele C. Hepatic synthesis of triacylglycerols containing medium-chain fatty acids is dominated by diacylglycerol acyltransferase 1 and efficiently inhibited by etomoxir. Mol Metab. 2021 Mar;45:101150. doi: 10.1016/j.molmet.2020.101150. Epub 2020 Dec 23. PMID: 33359403

Yu Z, Centola M, Valero J, Matthies M, Šulc P, Famulok M. A Self-Regulating DNA Rotaxane Linear Actuator Driven by Chemical Energy. J Am Chem Soc. 2021 Aug 25;143(33):13292-13298. doi: 10.1021/jacs.1c06226. Epub 2021 Aug 16. PMID: 34398597

2020

Becker M, Schultze H, Bresniker K, Singhal S, Ulas T, Schultze JL.  A novel computational architecture for large-scale genomics. Nat Biotechnol. 2020 Nov;38(11):1239-1241. doi: 10.1038/s41587-020-0699-5. PMID: 32999473

Bernardes JP, Mishra N, Tran F, Bahmer T, Best L, Blase JI, Bordoni D, Franzenburg J, Geisen U, Josephs-Spaulding J, Köhler P, Künstner A, Rosati E, Aschenbrenner AC, Bacher P, Baran N, Boysen T, Brandt B, Bruse N, Dörr J, Dräger A, Elke G, Ellinghaus D, Fischer J, Forster M, Franke A, Franzenburg S, Frey N, Friedrichs A, Fuß J, Glück A, Hamm J, Hinrichsen F, Hoeppner MP, Imm S, Junker R, Kaiser S, Kan YH, Knoll R, Lange C, Laue G, Lier C, Lindner M, Marinos G, Markewitz R, Nattermann J, Noth R, Pickkers P, Rabe KF, Renz A, Röcken C, Rupp J, Schaffarzyk A, Scheffold A, Schulte-Schrepping J, Schunk D, Skowasch D, Ulas T, Wandinger KP, Wittig M, Zimmermann J, Busch H, Hoyer BF, Kaleta C, Heyckendorf J, Kox M, Rybniker J, Schreiber S, Schultze JL, Rosenstiel P; HCA Lung Biological Network; Deutsche COVID-19 Omics Initiative (DeCOI). Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19. Immunity. 2020 Dec 15;53(6):1296-1314.e9. doi: 10.1016/j.immuni.2020.11.017. Epub 2020 Nov 26. PMID: 33296687

Beyer M, Abdullah Z, Chemnitz JM, Maisel D, Sander J, Lehmann C, Thabet Y, Shinde PV, Schmidleithner L, Köhne M, Trebicka J, Schierwagen R, Hofmann A, Popov A, Lang KS, Oxenius A, Buch T, Kurts C, Heikenwalder M, Fätkenheuer G, Lang PA, Hartmann P, Knolle PA, Schultze JL.  Publisher Correction: Tumor-necrosis factor impairs CD4+ T cell-mediated immunological control in chronic viral infection. Nat Immunol. 2020 Sep;21(9):1135. doi: 10.1038/s41590-020-0749-7. PMID: 32620862

Bonaguro L, Köhne M, Schmidleithner L, Schulte-Schrepping J, Warnat-Herresthal S, Horne A, Kern P, Günther P, Ter Horst R, Jaeger M, Rahmouni S, Georges M, Falk CS, Li Y, Mass E, Beyer M, Joosten LAB, Netea MG, Ulas T, Schultze JL, Aschenbrenner AC.  CRELD1 modulates homeostasis of the immune system in mice and humans. Nat Immunol. 2020 Dec;21(12):1517-1527. doi: 10.1038/s41590-020-00811-2. Epub 2020 Nov 9. PMID: 33169013

Cirovic B, de Bree LCJ, Groh L, Blok BA, Chan J, van der Velden WJFM, Bremmers MEJ, van Crevel R, Händler K, Picelli S, Schulte-Schrepping J, Klee K, Oosting M, Koeken VACM, van Ingen J, Li Y, Benn CS, Schultze JL, Joosten LAB, Curtis N, Netea MG, Schlitzer A. BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment. Cell Host Microbe. 2020 Aug 12;28(2):322-334.e5. doi: 10.1016/j.chom.2020.05.014. Epub 2020 Jun 15. PMID: 32544459

Giamarellos-Bourboulis EJ, Tsilika M, Moorlag S, Antonakos N, Kotsaki A, Domínguez-Andrés J, Kyriazopoulou E, Gkavogianni T, Adami ME, Damoraki G, Koufargyris P, Karageorgos A, Bolanou A, Koenen H, van Crevel R, Droggiti DI, Renieris G, Papadopoulos A, Netea MG. Activate: Randomized Clinical Trial of BCG Vaccination against Infection in the Elderly. Cell. 2020 Sep 1. pii: S0092-8674(20)31139-9. doi: 10.1016/j.cell.2020.08.051. [Epub ahead of print] PMID: 32941801

Miroschnikow A, Schlegel P, Pankratz MJ. Making Feeding Decisions in the Drosophila Nervous System. Curr Biol. 2020 Jul 20;30(14):R831-R840. doi: 10.1016/j.cub.2020.06.036. PMID: 32693083

Neubert P, Homann A, Wendelborn D, Bär AL, Krampert L, Trum M, Schröder A, Ebner S, Weichselbaum A, Schatz V, Linz P, Veelken R, Schulte-Schrepping J, Aschenbrenner AC, Quast T, Kurts C, Geisberger S, Kunzelmann K, Hammer K, Binger KJ, Titze J, Müller DN, Kolanus W, Schultze JL, Wagner S, Jantsch J. NCX1 represents an ionic Na+ sensing mechanism in macrophages. PLoS Biol. 2020 Jun 22;18(6):e3000722. doi: 10.1371/journal.pbio.3000722. eCollection 2020 Jun. PMID: 32569301

Pilsl S, Morgan C, Choukeife M, Möglich A, Mayer G.  Optoribogenetic control of regulatory RNA molecules. Nat Commun. 2020 Sep 24;11(1):4825. doi: 10.1038/s41467-020-18673-5. PMID: 32973178

Schulte-Schrepping J, Reusch N, Paclik D, Baßler K, Schlickeiser S, Zhang B, Krämer B, Krammer T, Brumhard S, Bonaguro L, De Domenico E, Wendisch D, Grasshoff M, Kapellos TS, Beckstette M, Pecht T, Saglam A, Dietrich O, Mei HE, Schulz AR, Conrad C, Kunkel D, Vafadarnejad E, Xu CJ, Horne A, Herbert M, Drews A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, Müller-Redetzky H, Heim KM, Machleidt F, Uhrig A, Bosquillon de Jarcy L, Jürgens L, Stegemann M, Glösenkamp CR, Volk HD, Goffinet C, Landthaler M, Wyler E, Georg P, Schneider M, Dang-Heine C, Neuwinger N, Kappert K, Tauber R, Corman V, Raabe J, Kaiser KM, Vinh MT, Rieke G, Meisel C, Ulas T, Becker M, Geffers R, Witzenrath M, Drosten C, Suttorp N, von Kalle C, Kurth F, Händler K, Schultze JL, Aschenbrenner AC, Li Y, Nattermann J, Sawitzki B, Saliba AE, Sander LE; Deutsche COVID-19 OMICS Initiative (DeCOI).Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment. Cell. 2020 Sep 17;182(6):1419-1440.e23. doi: 10.1016/j.cell.2020.08.001. Epub 2020 Aug 5 PMID: 32810438 

2019

Bekkering S, Stiekema LCA, Bernelot Moens S, Verweij SL, Novakovic B, Prange K, Versloot M, Roeters van Lennep JE, Stunnenberg H, de Winther M, Stroes ESG, Joosten LAB, Netea MG, Riksen NP. Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia. Cell Metab. 2019 Jul 2;30(1):1-2. doi: 10.1016/j.cmet.2019.05.014. Epub 2019 Jun 13. PubMed PMID: 31204280.

Camell CD, Günther P, Lee A, Goldberg EL, Spadaro O, Youm YH, Bartke A, Hubbard GB, Ikeno Y, Ruddle NH, Schultze J, Dixit VD. Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis. Cell Metab. 2019 Dec 3;30(6):1024-1039.e6. doi: 10.1016/j.cmet.2019.10.006. Epub 2019 Nov 14. PubMed PMID: 31735593; PubMed Central PMCID: PMC6944439.

Domínguez-Andrés J, Novakovic B, Li Y, Scicluna BP, Gresnigt MS, Arts RJW, Oosting M, Moorlag SJCFM, Groh LA, Zwaag J, Koch RM, Ter Horst R, Joosten LAB, Wijmenga C, Michelucci A, van der Poll T, Kox M, Pickkers P, Kumar V, Stunnenberg H, Netea MG. The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity. Cell Metab. 2019 Jan 8;29(1):211-220.e5. doi: 10.1016/j.cmet.2018.09.003. Epub 2018 Oct 4. PubMed PMID: 30293776.

Dos Santos JC, Barroso de Figueiredo AM, Teodoro Silva MV, Cirovic B, de Bree LCJ, Damen MSMA, Moorlag SJCFM, Gomes RS, Helsen MM, Oosting M, Keating ST, Schlitzer A, Netea MG, Ribeiro-Dias F, Joosten LAB. β-Glucan-Induced Trained Immunity Protects against Leishmania braziliensis Infection: a Crucial Role for IL-32. Cell Rep. 2019 Sep 3;28(10):2659-2672.e6. doi: 10.1016/j. celrep.2019.08.004. PubMed PMID: 31484076.

Dress RJ, Dutertre CA, Giladi A, Schlitzer A, Low I, Shadan NB, Tay A, Lum J, Kairi MFBM, Hwang YY, Becht E, Cheng Y, Chevrier M, Larbi A, Newell EW, Amit I, Chen J, Ginhoux F. Plasmacytoid dendritic cells develop from Ly6D(+) lymphoid progenitors distinct from the myeloid lineage. Nat Immunol. 2019 Jul;20(7):852-864. doi: 10.1038/s41590-019-0420-3. Epub 2019 Jun 18. PubMed PMID: 31213723.

Eggert F, Kurscheidt K, Hoffmann E, Kath-Schorr S. Towards Reverse Transcription with an Expanded Genetic Alphabet. Chembiochem. 2019 Jul 1;20(13):1642-1645. doi: 10.1002/cbic.201800808. Epub 2019 May 3. PubMed PMID: 30741472.

Goossens P, Rodriguez-Vita J, Etzerodt A, Masse M, Rastoin O, Gouirand V, Ulas T, Papantonopoulou O, Van Eck M, Auphan-Anezin N, Bebien M, Verthuy C, Vu Manh TP, Turner M, Dalod M, Schultze JL, Lawrence T. Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression. Cell Metab. 2019 Jun 4;29(6):1376-1389.e4. doi: 10.1016/j.cmet.2019.02.016. Epub 2019 Mar 28. PubMed PMID: 30930171.

Jacome-Galarza CE, Percin GI, Muller JT, Mass E, Lazarov T, Eitler J, Rauner M, Yadav VK, Crozet L, Bohm M, Loyher PL, Karsenty G, Waskow C, Geissmann F. Developmental origin, functional maintenance and genetic rescue of osteoclasts. Nature. 2019 Apr;568(7753):541-545. doi: 10.1038/s41586-019-1105-7. Epub 2019 Apr 10. PubMed PMID: 30971820; PubMed Central PMCID: PMC6910203.

Liu Z, Gu Y, Chakarov S, Bleriot C, Kwok I, Chen X, Shin A, Huang W, Dress RJ, Dutertre CA, Schlitzer A, Chen J, Ng LG, Wang H, Liu Z, Su B, Ginhoux F. Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells. Cell. 2019 Sep 5;178(6):1509-1525.e19. doi: 10.1016/j.cell.2019.08.009. PubMed PMID: 31491389.

Mikuličić S, Finke J, Boukhallouk F, Wüstenhagen E, Sons D, Homsi Y, Reiss K, Lang T, Florin L. ADAM17-dependent signaling is required for oncogenic human papillomavirus entry platform assembly. Elife. 2019 May 20;8. pii: e44345. doi: 10.7554/eLife.44345. PMID: 31107240.

Rosenthal M, Pfeiffer F, Mayer G. A Receptor-Guided Design Strategy for Ligand Identification. Angew Chem Int Ed Engl. 2019 Jul 29;58(31):10752-10755. doi: 10.1002/anie.201903479. Epub 2019 Jun 26. PubMed PMID: 31050104.

Thiele C, Wunderling K, Leyendecker P. Multiplexed and single cell tracing of lipid metabolism. Nat Methods. 2019 Nov;16(11):1123-1130. doi: 10.1038/s41592-019-0593-6. Epub 2019 Oct 14. PubMed PMID: 31611692.

Torres-Fernández LA, Jux B, Bille M, Port Y, Schneider K, Geyer M, Mayer G, Kolanus W. The mRNA repressor TRIM71 cooperates with Nonsense-Mediated Decay factors to destabilize the mRNA of CDKN1A/p21. Nucleic Acids Res. 2019 Dec 16;47(22):11861-11879. doi: 10.1093/nar/gkz1057. PubMed PMID: 31732746.

Weber AM, Kaiser J, Ziegler T, Pilsl S, Renzl C, Sixt L, Pietruschka G, Moniot S, Kakoti A, Juraschitz M, Schrottke S, Lledo Bryant L, Steegborn C, Bittl R, Mayer G, Möglich A. A blue light receptor that mediates RNA binding and translational regulation. Nat Chem Biol. 2019 Nov;15(11):1085-1092. doi: 10.1038/s41589-019-0346-y. Epub 2019 Aug 26. PubMed PMID: 31451761; PubMed Central PMCID: PMC6811359.

Yahia-Cherbal H, Rybczynska M, Lovecchio D, Stephen T, Lescale C, Placek K, Larghero J, Rogge L, Bianchi E. NFAT primes the human RORC locus for RORγt expression in CD4+T cells. Nat Commun. 2019 Nov 26;10(1):5450. doi: 10.1038/s41467-019-13451-4. PubMed PMID: 31772175; PubMed Central PMCID: PMC6879466

2018

Arts RJW, Moorlag SJCFM, Novakovic B, Li Y, Wang SY, Oosting M, Kumar V, Xavier RJ, Wijmenga C, Joosten LAB, Reusken CBEM, Benn CS, Aaby P, Koopmans MP, Stunnenberg HG, van Crevel R, Netea MG. BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity. Cell Host Microbe. 2018 Jan 10;23(1):89-100.e5. doi: 10.1016/j.chom.2017.12.010. PubMed PMID: 29324233.

Bakker OB, Aguirre-Gamboa R, Sanna S, Oosting M, Smeekens SP, Jaeger M, Zorro M, Võsa U, Withoff S, Netea-Maier RT, Koenen HJPM, Joosten I, Xavier RJ, Franke L, Joosten LAB, Kumar V, Wijmenga C, Netea MG, Li Y. Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses. Nat Immunol. 2018 Jul;19(7):776-786. doi: 10.1038/s41590-018-0121-3. Epub 2018 May 21. PubMed PMID: 29784908; PubMed Central PMCID: PMC6022810.

Bülow MH, Wingen C, Senyilmaz D, Gosejacob D, Sociale M, Bauer R, Schulze H, Sandhoff K, Teleman AA, Hoch M, Sellin J. Unbalanced lipolysis results in lipotoxicity and mitochondrial damage in peroxisome-deficient Pex19 mutants. Mol Biol Cell. 2018 Feb 15;29(4):396-407. doi: 10.1091/mbc.E17-08-0535. Epub 2017 Dec 27. PubMed 

Christ A, Günther P, Lauterbach MAR, Duewell P, Biswas D, Pelka K, Scholz CJ, Oosting M, Haendler K, Baßler K, Klee K, Schulte-Schrepping J, Ulas T, Moorlag SJCFM, Kumar V, Park MH, Joosten LAB, Groh LA, Riksen NP, Espevik T, Schlitzer A, Li Y, Fitzgerald ML, Netea MG, Schultze JL, Latz E. Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming. Cell. 2018 Jan 11;172(1-2):162-175.e14. doi: 10.1016/j.cell.2017.12.013. PubMed PMID: 29328911;  PubMed Central PMCID: PMC6324559.

Domenyuk V, Gatalica Z, Santhanam R, Wei X, Stark A, Kennedy P, Toussaint B, Levenberg S, Wang J, Xiao N, Greil R, Rinnerthaler G, Gampenrieder SP, Heimberger AB, Berry DA, Barker A, Quackenbush J, Marshall JL, Poste G, Vacirca JL, Vidal GA, Schwartzberg LS, Halbert DD, Voss A, Magee D, Miglarese MR, Famulok M, Mayer G, Spetzler D. Poly-ligand profiling differentiates trastuzumab-treated breast cancer patients according to their outcomes. Nat Commun. 2018 Mar 23;9(1):1219. doi: 10.1038/s41467-018-03631-z. PubMed PMID: 29572535; PubMed Central PMCID: PMC5865185.

Fülle L, Offermann N, Hansen JN, Breithausen B, Erazo AB, Schanz O, Radau L, Gondorf F, Knöpper K, Alferink J, Abdullah Z, Neumann H, Weighardt H, Henneberger C, Halle A, Förster I. CCL17 exerts a neuroimmune modulatory function and is expressed in hippocampal neurons. Glia. 2018 Oct;66(10):2246-2261. doi: 10.1002/glia.23507. Epub 2018 Sep 12. PubMed PMID: 30277599.

Fülle L, Steiner N, Funke M, Gondorf F, Pfeiffer F, Siegl J, Opitz FV, Haßel SK, Erazo AB, Schanz O, Stunden HJ, Blank M, Gröber C, Händler K, Beyer M, Weighardt H, Latz E, Schultze JL, Mayer G, Förster I. RNA Aptamers Recognizing Murine CCL17 Inhibit T Cell Chemotaxis and Reduce Contact Hypersensitivity In Vivo. Mol Ther. 2018 Jan 3;26(1):95-104. doi: 10.1016/j.ymthe.2017.10.005. Epub 2017 Oct 13. PubMed PMID: 29103909; PubMed Central PMCID: PMC5763148.

Haydell MW, Centola M, Adam V, Valero J, Famulok M. Temporal and Reversible Control of a DNAzyme by Orthogonal Photoswitching. J Am Chem Soc. 2018 Dec 12;140(49):16868-16872. doi: 10.1021/jacs.8b08738. Epub 2018 Nov 26. PubMed PMID: 30444607.

Kabrani E, Chu VT, Tasouri E, Sommermann T, Baßler K, Ulas T, Zenz T, Bullinger L, Schultze JL, Rajewsky K, Sander S. Nuclear FOXO1 promotes lymphomagenesis in germinal center B cells. Blood. 2018 Dec 20;132(25):2670-2683. doi: 10.1182/blood-2018-06-856203. Epub 2018 Oct 17. PubMed PMID: 30333121. 

Miroschnikow A, Schlegel P, Schoofs A, Hueckesfeld S, Li F, Schneider-Mizell CM, Fetter RD, Truman JW, Cardona A, Pankratz MJ. Convergence of monosynaptic and polysynaptic sensory paths onto common motor outputs in a Drosophila feeding connectome. Elife. 2018 Dec 11;7. pii: e40247. doi: 10.7554/eLife.40247. PubMed PMID: 30526854; PubMed Central PMCID: PMC6289573.

2017

Hofmann K, Lamberz C, Piotrowitz K, Offermann N, But D, Scheller A, Al-Amoudi A, Kuerschner L. Tanycytes and a differential fatty acid metabolism in the hypothalamus. Glia. 2017 Feb;65(2):231- 249. doi: 10.1002/glia.23088. Epub 2016 Oct 11. PubMed PMID: 27726181.

Merklinger E, Schloetel JG, Weber P, Batoulis H, Holz S, Karnowski N, Finke J, Lang T. The packing density of a supramolecular membrane protein cluster is controlled by cytoplasmic interactions. Elife. 2017 Jul 19;6. pii: e20705. doi: 10.7554/eLife.20705. PubMed PMID: 28722652; PubMed Central PMCID: PMC5536946.

Rieck M, Kremser C, Jobin K, Mettke E, Kurts C, Gräler M, Willecke K, Kolanus W. Ceramide synthase 2 facilitates S1P-dependent egress of thymocytes into the circulation in mice. Eur J Immunol. 2017 Apr;47(4):677-684. doi: 10.1002/eji.201646623. Epub 2017 Feb 27. PubMed PMID: 28198542.

Sander J, Schmidt SV, Cirovic B, McGovern N, Papantonopoulou O, Hardt AL, Aschenbrenner AC, Kreer C, Quast T, Xu AM, Schmidleithner LM, Theis H, Thi Huong LD, Sumatoh HRB, Lauterbach MAR, Schulte-Schrepping J, Günther P, Xue J, Baßler K, Ulas T, Klee K, Katzmarski N, Herresthal S, Krebs W, Martin B, Latz E, Händler K, Kraut M, Kolanus W, Beyer M, Falk CS, Wiegmann B, Burgdorf S, Melosh NA, Newell EW, Ginhoux F, Schlitzer A, Schultze JL. Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2. Immunity. 2017 Dec 19;47(6):1051-1066.e12. doi: 10.1016/j.immuni.2017.11.024. PubMed PMID: 29262348; PubMed Central PMCID: PMC5772172.

Schüller A, Matzner D, Lünse CE, Wittmann V, Schumacher C, Unsleber S, Brötz-Oesterhelt H, Mayer C, Bierbaum G, Mayer G. Activation of the glmS Ribozyme Confers Bacterial Growth Inhibition. Chembiochem. 2017 Mar 2;18(5):435-440. doi: 10.1002/cbic.201600491. Epub 2017 Jan 30. PubMed PMID: 28012261.

See P, Dutertre CA, Chen J, Günther P, McGovern N, Irac SE, Gunawan M, Beyer M, Händler K, Duan K, Sumatoh HRB, Ruffin N, Jouve M, Gea-Mallorquí E, Hennekam RCM, Lim T, Yip CC, Wen M, Malleret B, Low I, Shadan NB, Fen CFS, Tay A, Lum J, Zolezzi F, Larbi A, Poidinger M, Chan JKY, Chen Q, Rénia L, Haniffa M, Benaroch P, Schlitzer A, Schultze JL, Newell EW, Ginhoux F. Mapping the human DC lineage through the integration of high-dimensional techniques. Science. 2017 Jun 9;356(6342). pii: eaag3009. doi: 10.1126/science.aag3009. Epub 2017 May 4. PubMed PMID: 28473638.

Ulas T, Pirr S, Fehlhaber B, Bickes MS, Loof TG, Vogl T, Mellinger L, Heinemann AS, Burgmann J, Schöning J, Schreek S, Pfeifer S, Reuner F, Völlger L, Stanulla M, von Köckritz-Blickwede M, Glander S, Barczyk-Kahlert K, von Kaisenberg CS, Friesenhagen J, Fischer-Riepe L, Zenker S, Schultze JL, Roth J, Viemann D. S100-alarmin-induced innate immune programming protects newborn infants from sepsis. Nat Immunol. 2017 May 1. doi: 10.1038/ni.3745. [Epub ahead of print]100: Valero J, Lohmann F, Famulok M. Interlocked DNA topologies for nanotechnology. Curr Opin Biotechnol. 2017 Dec;48:159-167. doi: 10.1016/j.copbio.2017.04.002. Epub 2017 May 12. Review. PubMed PMID: 28505598.

Weber P, Batoulis H, Rink KM, Dahlhoff S, Pinkwart K, Söllner TH, Lang T. Electrostatic anchoring precedes stable membrane attachment of SNAP25/SNAP23 to the plasma membrane. Elife. 2017 Feb 27;6. pii: e19394. doi: 10.7554/eLife.19394. PubMed PMID: 28240595; PubMed Central PMCID: PMC5362264.

Wingen A, Carrera P, Ekaterini Psathaki O, Voelzmann A, Paululat A, Hoch M. Debris buster is a Drosophila scavenger receptor essential for airway physiology. Dev Biol. 2017 Oct 1;430(1):52-68. doi: 10.1016/j.ydbio.2017.08.018. Epub 2017 Aug 15. PubMed PMID: 28821389.

 

2016

Batoulis H, Schmidt TH, Weber P, Schloetel JG, Kandt C, Lang T. Concentration Dependent Ion-Protein Interaction Patterns Underlying Protein Oligomerization Behaviours. Sci Rep. 2016 Apr 7;6:24131. 

Beyer M, Abdullah Z, Chemnitz JM, Maisel D, Sander J, Lehmann C, Thabet Y, Shinde PV, Schmidleithner L, Köhne M, Trebicka J, Schierwagen R, Hofmann A, Popov A, Lang KS, Oxenius A, Buch T, Kurts C, Heikenwalder M, Fätkenheuer G, Lang PA, Hartmann P, Knolle PA, Schultze JL. Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection. Nat Immunol. 2016 May;17(5):593-603. 

Brandstätter O, Schanz O, Vorac J, König J, Mori T,  Maruyama T, Korkowski M, Haarmann-Stemmann T, von Smolinski D, Schultze JL, Abel J, Esser Ch, Takeyama H, Weighardt H, Förster I. Balancing intestinal and systemic inflammation through cell type-specific expression of the aryl hydrocarbon receptor repressor. Sci Rep. 2016 May 17;6:26091.

Gaebler A, Penno A, Kuerschner L, Thiele C. A highly sensitive protocol for microscopy of alkyne lipids and fluorescently tagged or immunostained proteins. J Lipid Res. 2016 Oct;57(10):1934-1947. PubMed PMID: 27565170; PubMed Central PMCID: PMC5036357.

Gosejacob D, Jäger PS, Vom Dorp K, Frejno M, Carstensen AC, Köhnke M, Degen J, Dörmann P, Hoch M. Ceramide Synthase 5 Is Essential to Maintain C16:0-Ceramide Pools and Contributes to the Development of Diet-induced Obesity. J Biol Chem. 2016 Mar 25;291(13):6989-7003. 

Hückesfeld S, Peters M, Pankratz MJ. Central relay of bitter taste to the protocerebrum by peptidergic interneurons in the Drosophila brain. Nat Commun. 2016 Sep 13;7:12796. doi: 10.1038/ncomms12796. PubMed PMID: 27619503; PubMed Central PMCID: PMC5027282.

Kreer C, Kuepper JM, Zehner M, Quast T, Kolanus W, Schumak B, Burgdorf S. N-glycosylation converts non-glycoproteins into mannose receptor ligands and reveals antigen-specific T cell responses in vivo. Oncotarget. 2016 Dec 28. doi: 10.18632/oncotarget.14314. [Epub ahead of print] PubMed PMID: 28036287.

Pfeiffer F, Mayer G. Selection and Biosensor Application of Aptamers for Small Molecules. Front Chem. 2016 Jun 15;4:25. 

Schlegel P, Texada MJ, Miroschnikow A, Schoofs A, Hückesfeld S, Peters M, Schneider-Mizell CM, Lacin H, Li F, Fetter RD, Truman JW, Cardona A, Pankratz MJ. Synaptic transmission parallels neuromodulation in a central food-intake circuit. Elife. 2016 Nov 15;5. pii: e16799. doi: 10.7554/eLife.16799. PubMed PMID: 27845623; PubMed Central PMCID: PMC5182061.

Schoofs A, Pankratz MJ. Neuroscience: Hunger Pangs in the Fly Brain. Curr Biol. 2016 Aug 8;26(15):R701-3. 

Schuette V, Embgenbroich M, Ulas T, Welz M, Schulte-Schrepping J, Draffehn AM, Quast T, Koch K, Nehring M, König J, Zweynert A, Harms FL, Steiner N, Limmer A, Förster I, Berberich-Siebelt F, Knolle PA, Wohlleber D, Kolanus W, Beyer M, Schultze JL, Burgdorf S. Mannose receptor induces T-cell tolerance via inhibition of CD45 and up-regulation of CTLA-4. Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):10649-54. doi: 10.1073/pnas.1605885113. PubMed PMID: 27601670; PubMed Central PMCID: PMC5035904.

Schultze JL, Beyer M. Myelopoiesis Reloaded: Single-Cell Transcriptomics Leads the Way. Immunity. 2016 Jan 19;44(1):18-20. 

Weigandt J, Chung CL, Jester SS, Famulok M. Daisy Chain Rotaxanes Made from Interlocked DNA Nanostructures. Angew Chem Int Ed Engl. 2016 Apr 25;55(18):5512-6. 

 

2015

Destainville N, Schmidt TH, Lang T. Where Biology Meets Physics-A Converging View on Membrane Microdomain Dynamics. Curr Top Membr. 2016;77:27-65. doi: 10.1016/bs.ctm.2015.10.004. Epub 2015 Nov 27.

Kath-Schorr S, Cycloadditions for studying nucleic acids. Topics in Current Chemistry, 2015, 374, 1-27.

Lennarz S, Alich TC, Kelly T, Blind M, Beck H, Mayer G. Selective aptamer-based control of intraneuronal signaling. Angew Chem Int Ed Engl. 2015 Apr 27;54(18):5369-73. doi: 10.1002/anie.201409597. Epub 2015 Mar 5. PubMed PMID: 25754968.

Matzner D, Mayer G. (Dis)similar Analogues of Riboswitch Metabolites as Antibacterial Lead Compounds. J Med Chem. 2015 Apr 23;58(8):3275-86.

Mitschka S, Ulas T, Goller T, Schneider K, Egert A, Mertens J, Brüstle O, Schorle H, Beyer M, Klee K, Xue J, Günther P, Bassler K, Schultze JL, Kolanus W. Co-existence of intact stemness and priming of neural differentiation programs in mES cells lacking Trim71. Sci Rep. 2015 Jun 9;5:11126.

Richard M, Hoch M. Drosophila eye size is determined by Innexin 2-dependent Decapentaplegic signalling. Dev Biol. 2015 Dec 1;408(1):26-40. 

Schultze JL. Teaching ‚big data‘ analysis to young immunologists. Nat Immunol. 2015 Sep;16(9):902-5. 

Tolle F, Brändle GM, Matzner D, Mayer G. A Versatile Approach Towards Nucleobase-Modified Aptamers. Angew Chem Int Ed Engl. 2015 Sep 7;54(37):10971-4. 

Zehner M, Marschall AL, Bos E, Schloetel JG, Kreer C, Fehrenschild D, Limmer A, Ossendorp F, Lang T, Koster AJ, Dübel S, Burgdorf S. The translocon protein Sec61 mediates antigen transport from endosomes in the cytosol for cross-presentation to CD8(+) T cells. Immunity. 2015 May 19;42(5):850-63.

2014

Mass E, Wachten D, Aschenbrenner AC, Voelzmann Aand Hoch M. (2014). Murine Creld1 Controls Cardiac Development through Activation of Calcineurin/NFATc1 Signaling. Developmental cell, 28(6), 711-726.

Xue J, Schmidt SV, Sander J, Draffehn A, Krebs W, Quester I, De Nardo D, Gohel TD, Emde M, Schmidleithner L, Hariharasudan G, Nino-Castro A, Mallmann M, Labzin L, Theis H, Kraut M, Beyer M, Latz E, Freeman TC, Ulas T and Schultze JL. (2014). Transcriptome-based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation. Immunity, Feb 20;40(2):274-88.

Sommer D, Peters A, Wirtz T, Mai M, Ackermann J, Thabet Y, Schmidt J, Weighardt H, Wunderlich FT, Degen J, Schultze JL and Beyer M. (2014). Efficient genome engineering by targeted homologous recombination in mouse embryos using transcription activator-like effector nucleases. Nature communications,  Jan 13;5:3045. doi: 10.1038/ncomms4045.

2013

De Nardo D, Labzin LI, Kono H, Seki R, Schmidt SV, Beyer M, Xu D, Zimmer S, Lahrmann C, Schilberg FA, Vogelhuber J, Kraut M, Ulas T, Kerksiek A, Krebs W, Bode N, Grebe A, Fitzgerald ML, Hernandez NJ, Williams B, Knolle PA, Kneiling M, Rocken M, Lutjohann D, Wright SD, Schultze JL and Latz E. (2013). High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via transcriptional regulator ATF3. Nature Immunology, 2014 Feb;15(2):152-60. Epub 2013 Dec 8.

Li T and Famulok M. (2013). I-motif-programmed functionalization of DNA nanocircles. Journal of the American Chemical Society, 135(4), 1593-1599.

2012

McInnes N, Sadlon TJ, Brown CY, Pederson S, Beyer M, Schultze JL, McColl S, Goodall GJ and Barry SC. (2012). FOXP3 and FOXP3-regulated microRNAs suppress SATB1 in breast cancer cells. Oncogene, 31(8), 1045-1054.

Lohmann F, Ackermann D and Famulok M. (2012). Reversible light switch for macrocycle mobility in a DNA rotaxane. Journal of the American Chemical Society, 134(29), 11884-11887.

Li T, Ackermann D, Hall AM and Famulok M. (2012). Input-dependent induction of oligonucleotide structural motifs for performing molecular logic. Journal of the American Chemical Society, 134(7), 3508-3516.

Li J, Malaby AW, Famulok M, Sabe H, Lambright DG and Hsu VW. (2012). Grp1 plays a key role in linking insulin signaling to glut4 recycling. Developmental cell, 22(6), 1286-1298.

Khodosevich K, Zuccotti A, Kreuzberg MM, Le Magueresse C, Frank M, Willecke K and Monyer H. (2012). Connexin45 modulates the proliferation of transit-amplifying precursor cells in the mouse subventricular zone. Proceedings of the National Academy of Sciences of the United States of America, 109(49), 20107-20112.

Jennemann R, Rabionet M, Gorgas K, Epstein S, Dalpke A, Rothermel U, Bayerle A, van der Hoeven F, Imgrund S, Kirsch J, Nickel W, Willecke K, Riezman H, Grone HJ and Sandhoff R. (2012). Loss of ceramide synthase 3 causes lethal skin barrier disruption. Human molecular genetics, 21(3), 586-608.

Contreras FX, Ernst AM, Haberkant P, Bjorkholm P, Lindahl E, Gonen B, Tischer C, Elofsson A, von Heijne G, Thiele C, Pepperkok R, Wieland F and Brugger B. (2012). Molecular recognition of a single sphingolipid species by a protein's transmembrane domain. Nature, 481(7382), 525-529.

2011

Zehner M, Chasan AI, Schuette V, Embgenbroich M, Quast T, Kolanus W and Burgdorf S. (2011). Mannose receptor polyubiquitination regulates endosomal recruitment of p97 and cytosolic antigen translocation for cross-presentation. Proceedings of the National Academy of Sciences of the United States of America, 108(24), 9933-9938.

Tress O, Maglione M, Zlomuzica A, May D, Dicke N, Degen J, Dere E, Kettenmann H, Hartmann D and Willecke K. (2011). Pathologic and phenotypic alterations in a mouse expressing a connexin47 missense mutation that causes Pelizaeus-Merzbacher-like disease in humans. PLoS genetics, 7(7), e1002146.

Schutz M, Auth T, Gehrt A, Bosen F, Korber I, Strenzke N, Moser T and Willecke K. (2011). The connexin26 S17F mouse mutant represents a model for the human hereditary keratitis-ichthyosis-deafness syndrome. Human molecular genetics, 20(1), 28-39.

Quast T, Eppler F, Semmling V, Schild C, Homsi Y, Levy S, Lang T, Kurts C and Kolanus W. (2011). CD81 is essential for the formation of membrane protrusions and regulates Rac1-activation in adhesion-dependent immune cell migration. Blood, 118(7), 1818-1827.

Hagen N, Hans M, Hartmann D, Swandulla D and van Echten-Deckert G. (2011). Sphingosine-1-phosphate links glycosphingolipid metabolism to neurodegeneration via a calpain-mediated mechanism. Cell death and differentiation, 18(8), 1356-1365.

Bill A, Blockus H, Stumpfe D, Bajorath J, Schmitz A and Famulok M. (2011). A homogeneous fluorescence resonance energy transfer system for monitoring the activation of a protein switch in real time. Journal of the American Chemical Society, 133(21), 8372-8379.

Beyer M, Thabet Y, Muller RU, Sadlon T, Classen S, Lahl K, Basu S, Zhou X, Bailey-Bucktrout SL, Krebs W, Schonfeld EA, Bottcher J, Golovina T, Mayer CT, Hofmann A, Sommer D, Debey-Pascher S, Endl E, Limmer A, Hippen KL, Blazar BR, Balderas R, Quast T, Waha A, Mayer G, Famulok M, Knolle PA, Wickenhauser C, Kolanus W, Schermer B, Bluestone JA, Barry SC, Sparwasser T, Riley JL and Schultze JL. (2011). Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation. Nature immunology, 12(9), 898-907.

2010

Bill A, Schmitz A, Albertoni B, Song JN, Heukamp LC, Walrafen D, Thorwirth F, Verveer PJ, Zimmer S, Meffert L, Schreiber A, Chatterjee S, Thomas RK, Ullrich RT, Lang T and Famulok M. (2010). Cytohesins are cytoplasmic ErbB receptor activators. Cell, 143(2), 201-211.

Stutte S, Quast T, Gerbitzki N, Savinko T, Novak N, Reifenberger J, Homey B, Kolanus W, Alenius H and Förster I. (2010). Requirement of CCL17 for CCR7- and CXCR4-dependent migration of cutaneous dendritic cells. Proceedings of the National Academy of Sciences of the United States of America, 107(19), 8736-8741.

Mayer G, Ahmed MS, Dolf A, Endl E, Knolle PA and Famulok M. (2010). Fluorescence-activated cell sorting for aptamer SELEX with cell mixtures. Nature protocols, 5(12), 1993-2004.

Burgdorf S, Schuette V, Semmling V, Hochheiser K, Lukacs-Kornek V, Knolle PA and Kurts C. (2010). Steady-state cross-presentation of OVA is mannose receptor-dependent but inhibitable by collagen fragments. Proceedings of the National Academy of Sciences of the United States of America, 107(13), E48-49; author reply E50-41.

Becker T, Loch G, Beyer M, Zinke I, Aschenbrenner AC, Carrera P, Inhester T, Schultze JL and Hoch M. (2010). FOXO-dependent regulation of innate immune homeostasis. Nature, 463(7279), 369-373.

Ackermann D, Schmidt TL, Hannam JS, Purohit CS, Heckel A and Famulok M. (2010). A double-stranded DNA rotaxane. Nature nanotechnology, 5(6), 436-442.

2009

Quast T, Tappertzhofen B, Schild C, Grell J, Czeloth N, Forster R, Alon R, Fraemohs L, Dreck K, Weber C, Lammermann T, Sixt M and Kolanus W. (2009). Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells. Blood, 113(23), 5801-5810.

Klotz L, Burgdorf S, Dani I, Saijo K, Flossdorf J, Hucke S, Alferink J, Nowak N, Beyer M, Mayer G, Langhans B, Klockgether T, Waisman A, Eberl G, Schultze J, Famulok M, Kolanus W, Glass C, Kurts C and Knolle PA. (2009). The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity. The Journal of experimental medicine, 206(10), 2079-2089.

Dobrowolski R, Hertig G, Lechner H, Worsdorfer P, Wulf V, Dicke N, Eckert D, Bauer R, Schorle H and Willecke K. (2009). Loss of connexin43-mediated gap junctional coupling in the mesenchyme of limb buds leads to altered expression of morphogens in mice. Human molecular genetics, 18(15), 2899-2911.

Beyer M, Karbach J, Mallmann MR, Zander T, Eggle D, Classen S, Debey-Pascher S, Famulok M, Jager E and Schultze JL. (2009). Cancer vaccine enhanced, non-tumor-reactive CD8(+) T cells exhibit a distinct molecular program associated with "division arrest anergy". Cancer research, 69(10), 4346-4354.

Bauer R, Voelzmann A, Breiden B, Schepers U, Farwanah H, Hahn I, Eckardt F, Sandhoff K and Hoch M. (2009). Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila. The EMBO journal, 28(23), 3706-3716.

2008

Loer B, Bauer R, Bornheim R, Grell J, Kremmer E, Kolanus W and Hoch M. (2008). The NHL-domain protein Wech is crucial for the integrin-cytoskeleton link. Nature cell biology, 10(4), 422-428.

Hafner M, Vianini E, Albertoni B, Marchetti L, Grune I, Gloeckner C and Famulok M. (2008). Displacement of protein-bound aptamers with small molecules screened by fluorescence polarization. Nature protocols, 3(4), 579-587.

Burgdorf S, Scholz C, Kautz A, Tampe R and Kurts C. (2008). Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation. Nature immunology, 9(5), 558-566.

Buch S, Melcher C, Bauer M, Katzenberger J and Pankratz MJ. (2008). Opposing effects of dietary protein and sugar regulate a transcriptional target of Drosophila insulin-like peptide signaling. Cell metabolism, 7(4), 321-332.

2007

Roell W, Lewalter T, Sasse P, Tallini YN, Choi BR, Breitbach M, Doran R, Becher UM, Hwang SM, Bostani T, von Maltzahn J, Hofmann A, Reining S, Eiberger B, Gabris B, Pfeifer A, Welz A, Willecke K, Salama G, Schrickel JW, Kotlikoff MI and Fleischmann BK. (2007). Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia. Nature, 450(7171), 819-824.

Gareus R, Huth M, Breiden B, Nenci A, Rosch N, Haase I, Bloch W, Sandhoff K and Pasparakis M. (2007). Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation. Nature cell biology, 9(4), 461-469.

Burgdorf S, Kautz A, Bohnert V, Knolle PA and Kurts C. (2007). Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation. Science, 316(5824), 612-616.

Behr M, Wingen C, Wolf C, Schuh R and Hoch M. (2007). Wurst is essential for airway clearance and respiratory-tube size control. Nature cell biology, 9(7), 847-853.

2006

Hafner M, Schmitz A, Grune I, Srivatsan SG, Paul B, Kolanus W, Quast T, Kremmer E, Bauer I and Famulok M. (2006). Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistance. Nature, 444(7121), 941-944.

Fuss B, Becker T, Zinke I and Hoch M. (2006). The cytohesin Steppke is essential for insulin signalling in Drosophila. Nature, 444(7121), 945-948.