Originalarbeiten

  • Tang, Y., Majewska, M., Leß B., Mehmeti I., Wollnitzke P., Semleit N., Levkau B., Saba D.J., van Echten-Deckert G., Gurgul-Convey E. "The fate of intracellular S1P regulates lipid droplet turnover and lipotoxicity in pancreatic beta-cells" J.Lipid Res. 65,100587 (2024)  https://doi.org/10.1016/j.jlr.2024.100587

  • Wollnitzke P., Wagner R., Afsar Y.S., Werner M., Geschold R., Müller E.C., Werz O., van Echten-Deckert G., Menche D. "Synthesis and biological evaluation of simplified ajudazol derivatives reveal potent 5-lipoxygenase inhibition and considerable apoptotic activity in neuroblastoma cells" Biorg.Med.Chem.Lett. 93, 129464 (2023) doi.org/10.1016/j.bmcl.2023.129464

  • Alam, S.; Afsar, S.Y.; Wolter, M.A.; Volk, L.M.; Mitroi, D.N.; Meyer Zu Heringdorf, D.; van Echten-Deckert, G. "S1P Lyase Deficiency in the Brain Promotes Astrogliosis and NLRP3 Inflammasome Activation via Purinergic Signaling". Cells 12, (2023) DOI: 10.3390/cells12141844
  • van Echten-Deckert, G. "The role of sphingosine 1-phosphate metabolism in brain health and disease" Pharmacol. Ther. 244, 108381 (2023) DOI: 10.1016/j.pharmthera.2023.108381
  • Alam, S., Afsar, S.Y., van Echten-Deckert, G. "S1P Released by SGPL1-Deficient Astrocytes Enhances Astrocytic ATP Production via S1PR2,4, Thus Keeping Autophagy in Check: Potential Consequences for Brain Health"  IJMS (2023) DOI: 10.3390/ijms24054581
  • Afsar, S.Y., Alam, S., Fernandez Gonzales, C., van Echten-Deckert, G. "Sphingosine-1-phosphate-lyase deficiency affects glucose metabolism in a way that abets oncogenesis" Mol. Oncol. 16, 3642 - 3653 (2022) http://doi.org/10.1002/1878-0261.13300
  • Piazessi, A., Wang, Y., Jackson1, J., Wischhof, L., Zeisler-Diehl, V., Scifo, E., Oganezova, I., Hoffmann, T., Gomez Martin, P., Bertan, F., Wrobel, CJJ, Schroeder, FC, Ehninger, D., Händler K., Schultze, JL, Schreiber, L., van Echten-Deckert, G.,  Nicotera, P., & Bano, D. "CEST‐2.2 overexpression alters lipid metabolism and extends longevity of mitochondrial mutants". EMBO J. 23: e52606 (2022)  http://doi.org/10.15252/embr.202152606
  • Piazzesi, A., Afsar, S.Y., van Echten-Deckert, G. "Sphingolipid metabolism in the development and progression of cancer: one cancer's help is another's hindrance". Mol. Oncol. 15, 3256-79 (2021) https://doi.org/10.1002/1878-0261.13063
  • Iwama, T., Kano, K., Saigusa, D., Ekroos, K., van Echten-Deckert, G., Vogt, J., Aoki, J. Development of an on-tissue derivatization method for MALDI mass spectrometry imaging of bioactive lipids containing phosphate monoester using Phos-tag. Anal. Chem. 93 (8): 3867-75 (2021) https://pubs.acs.org/doi/10.1021/acs.analchem.0c04479
  • Bethlehem, L., van Echten-Deckert, G. Ectoines as novel anti-inflammatory and tissue protective lead compounds with special focus on inflammatory bowel disease and lung inflammation, Pharmacol. Res. 164:105389 (2021) https://doi.org/10.1016/j.phrs.2020.105389
  • van Echten-Deckert, G. Guest Editor, Special Issue on "Sphingolipids: From Pathology to Therapeutic Perspectives", Cells 9(11):2404 (2020) https://www.mdpi.com/journal/cells/special_issues/Sphingolipids_Pathology; https://doi.org/10.3390/cells9112404
  • Alam, S., Piazzesi, A., Abd El Fatah, M., Raucamp, M., van Echten-Deckert, G. Neurodegeneration Caused by S1P-Lyase Deficiency Involves Calcium-Dependent Tau Pathology and Abnormal Histone Acetylation, Cells 9:2189 (2020) https://doi.org/10.3390/cells9102189
  • Zeisler-Diehl, V., Ali Ali Al-Khutabi, E., Kirfel, G., van Echten-Deckert, G., Herzog, V. Detection of endogenous lipids in chicken feathers distinct from preen gland constituents, Protoplasma, 257 (6):1709 - 1724 (2020) https://doi.org/10.1007/s00709-020-01544-7
  • van Kruining, D., Luoa, Q., van Echten-Deckert, G., Mielke, M.M., Bowmand, A., Ellis, S., Oliveirae, T.G., Martinez-Martine, P. Sphingolipids as Prognostic Biomarkers of Neurodegeneration, Neuroinflammation, and Psychatric Diseases and their Emerging Role in Lipidomic Investigation Methods, Advanced Drug Delivery Reviews, in press (2020) https://doi.org/10.1016/j.addr.2020.04.009
  • Hagen-Euteneuer, N., Alam, S., Rindsfuesser, H., Meyer zu Heringdorf, D., van Echten-Deckert, G. S1P-lyase deficiency uncouples ganglioside formation - Potential contribution to tumorigenic capacity. BBA-Molecular and Cell Biology of Lipids 1865:158708 (2020) https://doi.org/10.1016/j.bbalip.2020.158708
  • Karunakaran, I., Alam, S., Jayagopi, S., Frohberger, S.J., Hansen, J.N., Kuehlwein. J., Hölbling, B., Schumak, B., Hübner, M.P., Gräler, M.H., Halle, A., van Echten-Deckert, G. Neural sphingosine 1-phosphate accumulation activates microglia and links impaired autophagy and inflammation. GLIA, 67:1859 - 1872 (2019) https://doi.org/10.1002/glia.23663
  • van Echten-Deckert, G., Alam, S. Sphingolipid metabolism - an ambiguous regulator of autophagy in the brain. Biol Chem 399(8): 837 - 850 (2018) https://doi.org/10.1515/hsz-2018-0237
  • Mitroi, D.N., Karunakaran, I., Gräler, M., Saba, J., Ehninger, D., Ledesma, M.D., van Echten-Deckert, G. SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production. Autophagy, 13: 885 - 899 (2017)
    www.tandfonline.com/doi/full/10.1080/15548627.2017.1291471
  • Karunakaran, I., van Echten-Deckert, G. Sphingosine 1-phosphate - A double edged sword in the brain. BBA-Biomembranes 1858 (9): 1573-1582 (2017) dx.doi.org/10.1016/j.bbamem.2017.03.008

  • Vienken, H., Mabrouki, N., Grabau, K., Class, R.F., Rudowski, A., Schömel, N., Pfeilschifter, J., Lütjohann, D., van Echten-Deckert, G., Meyer zu Heringdorf, D. Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibriblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca2+ storage. Sci. Rep. 7, 43575; doi: 10.1038/srep43575 (2017) www.nature.com/articles/srep43575

  • Mitroi, D.N., Deutschman, A., Raucamp, M., Karunakaran, I., Glebov, K., Hans, M., Walter, J., Saba, J., Gräler, M., Ehninger, D., Sopova, E., Shupliakov, O., Swandulla, D., van Echten-Deckert, G. Sphingosine 1-phosphate lyase ablation disrupts presynaptic architecture and function via an ubiquitin - proteasome mediated mechanism. Sci. Rep. 6, 37064; doi:10.1038/srep37064 (2016) rdcu.be/mWJ7
  • van Echten-Deckert, G., Hagen-Euteneuer, N., Karaca, I., Walter, J. Sphingosine-1-phosphate: boon and bane for the brain. Cell Physiol Biochem., 34: 148-57 (2014)
  • Karaca, I., Tamboli, I.Y., Glebov, K., Richter, J., Fell, L.H., Grimm, M.O., Haupenthal, V.J., Hartmann, T., Graeler, M.H., van Echten-Deckert, G., Walter, J. Deficiency of sphingosine-1-phosphate lyase impairs lysosomal metabolism of the amyloid precursor protein  J. Biol. Chem., 289: 16761-72 (2014)
    http://www.ncbi.nlm.nih.gov/pubmed/24808180
  • Srinivasan, P.K., Ngwi Fet, N., Bleilevens, C., Afify, M. , Doorschodt, B., Yagi, S., van Echten-Deckert, G., Tolba, R.H. Hydroxyectoine ameliorates preservation injury in deceased after cardiac death donors in experimental liver grafts. Ann. Transplant., 19:165-73 (2014)
  • Wedeking A., Hagen-Euteneuer, N., Gurgui, M., Broere, R., Lentzen, Tolba, R.H., Galinski, E., van Echten-Deckert, G. A Lipid Anchor Improves the protective Effect of Ectoine in Inflammation. Curr. Med. Chem., 21: 2565-72 (2014)
  • Nakabachi, R. Ueoka, K. Oshima, R. Teta, A. Mangoni, M. Gurgui, N.J. Oldham, G. van Echten-Deckert, K. Okamura, Y. Hongoh, S. Miyagishima, M. Hattori, J. Piel and T. Fukatsu. Defensive Bacteriome Symbiont with a Drastically Reduced Genome. Curr. Biol., 23: 1478-84 (2013) doi: 10.1016/j.cub.2013.06.027. Epub 2013 Jul 11.
  • Pech, T., Ohsawa, I., Praktiknjo, M., Overhaus, M., Wehner, S., Abu-Elmagd, K., van Echten-Deckert, G., Kalff, C.J., Schaefer, N. A natural tetrahydropyrimidine (ectoine) ameliorates ischemia reperfusion injury after intestinal transplantation in rats. Pathobiology, 80: 102-110 (2013)
  • Walter, Jochen, van Echten-Deckert, Gerhild: Cross-talk of membrane lipids and Alzheimer-related proteins. Mol. Neurodegen. 8:34-45 (2013)
  • Taube, A., Lambernd, S., van Echten-Deckert, G., Eckard, K., Eckel, J. Adipokines Promote Lipotoxicity in Human Skeletal Muscle Cells Arch. Physiol. Biochem. 12: 92-101 (2012)
  • Hagen-Euteneuer, N, Lütjohann, D., Park, H., Merrill, A.H.Jr., van Echten-Deckert G. S1P-lyase-deficiency increases sphingolipid formation via recycling pathway on expense of de novo biosynthesis. J. Biol. Chem. 287: 9128-9136 (2012 ) 
    http://www.jbc.org/content/early/2012/01/30/jbc.M111.302380.full.pdf+html
  • van Echten-Deckert, Gerhild, Walter, Jochen. Sphingolipids: Critical players in Alzheimer's disease. Prog Lipid Res 51: 378-393 (2012)
  • Hagen, N., Hans, M., Hartmann, D., Swandulla, D., van Echten-Deckert, G. Sphingosine-1-phosphate links sphingolipid metabolism to neurodegeneration via a calpain-mediated mechanism. Cell Death Differ. 18: 1356-1365 (2011)
    http://www.nature.com/cdd/journal/vaop/ncurrent/full/cdd20117a.html
  • ter Braak, M., Claas, R.F., Hegen, B., Labocha, S., Ferreirós, N., Pfeilschifter, J., Huwiler, A., van Echten-Deckert, G., Meyer zu Heringdorf D. Cis-4-Methylsphingosine is a Sphingosine-1-phosphate Receptor Modulator. Biochem. Pharmacol. 81: 617-625 (2011)
  • Teta, R., Gurgui, M., Helfrich, E.J.N., Künne, S., Van Echten-Deckert, G., Mangon, A., Piel, J. Genome Mining Reveals trans-AT Polyketide Synthase-Directed Antibiotic Biosynthesis in the Bacterial Phylum Bacteroidetes. ChemBioChem. 11: 2506 – 2512 (2010)
  • Gurgui, M, Broere, R., Kalff, J.C., van Echten-Deckert, G. Dual action of sphingosine 1-phosphate in eliciting proinflammatory responses in primary cultured rat intestinal smooth muscle cells. Cell Signal 22: 1727-1733 (2010)
  • Wei, L., Wedeking, A., Büttner, R., Kalff, C.J., Tolba, H.R., van Echten-Deckert, G. A natural tetrahydropyrimidine protects small bowel from cold ischemia and subsequent warm in vitro reperfusion injury. Pathobiology 76: 212-220 (2009)
  • Hagen, N., Van Veldhoven P.P., Proia R.L., Park, H., Merill, H.A.Jr., van Echten-Deckert, G. Subcellular origin of sphingosine-1-phosphate is essential for its toxic effect in lyase-deficient neurons. J. Biol. Chem. 284: 11346-53 (2009)
  • Sell, H., Eckardt, K., Taube, A., Tews, D., Gurgui, M., van Echten-Deckert, G., Eckel, J. Skeletal muscle insulin resistance induced by adipocyte-conditioned medium: underlying mechanisms and reversibility. Am. J. Physiol. 294: E1070-1077 (2008)
  • Tauzin, S., Ding, Heidrun, Khatib, Karim, Ahmad, Ishtiag, Burdevet, Dimitri, van Echten-Deckert, Gerhild, Lindquist, A. Jonathan, Schraven, Burkhart, Nasir-du-Din, Borisch, Bettina, Hoessli, C. Daniel. Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts. Blood 111:2310-20 (2008)
  • van Echten-Deckert, Gerhild, Gurgui Mihaela. Golgi localization of glycosyltransferases involved in ganglioside biosynthesis. Curr. Drug Targets 9(4), 282-291 (2008)
  • Broere, R, Gurgui, M, van Echten-Deckert, G. Identification of target genes of sphingosine-1-phosphate using DualChip technology in intestinal smooth muscle cells. Supplement to Chim. Oggi/CHEM. TODAY 25, 28-30 (2007)
  • Kralj, A., Gurgui, M., König, M.G., van Echten-Deckert, G. Trichothecenes induce accumulation of glucosylceramide in neural cells by interfering with lactosylceramide synthase activity. Toxicol. Appl. Pharmacol. 225, 113-122 (2007)
  • Kralj, Ana, Kehraus, Stefan, Krick, Anja, van Echten-Deckert, Gerhild, König, Gabriele M. Two New Depsipeptides from the Marine Fungus Spicellum roseum. Planta medica 73, 366-371 (2007)
  • van Echten-Deckert, Gerhild, Saathoff H Manuela, Kirfel, Gregor, Herzog, Volker. Specific distribution of barrier-relevant ceramides in the developing epidermis and the periderm/subperiderm cell-layers during chicken embryogenesis. Eur. J. Cell Biol. 86, 675-682 (2007)
  • Wedeking, Annika, van Echten-Deckert, Gerhild. Glycosphingolipid structure and function in membranes. Curr. Org. Chem. 11, 579-589 (2007)
  • Dragusin, Mihaela, Wehner, Sven, Kelly, Samuel, Wang, Elaine, Merrill, Alfred H. Jr.,  Kalff, Jörg C., van Echten-Deckert, Gerhild. Effects of sphingosine-1-phosphate and ceramide-1-phosphate on rat intestinal smooth muscle cells: implications in postoperative ileus. The FASEB J 20, 1930-1932 (2006)
  • Nätzker, Sven, Hagen, Nadine, van Echten-Deckert, Gerhild. Activation of p38 mitogen-activated protein kinase and partial reactivation of the cell cycle by cis-4-methylsphingosine direct post-mitotic neurons towards apoptosis. Genes to Cells 11, 269-279 (2006)
  • van Echten-Deckert, Gerhild, Herget, Thomas. Sphingolipid metabolism in neural cells. Biochim. Biophys. Acta - Biomembranes 1758, 1978-1994 (2006)
  • Wedeking, Annika, van Echten-Deckert, Gerhild. Sphingolipid metabolism and function in nerve tissue. In: Sphingolipids and Cell Function (E. Albi, S.G. Pandalai, V. Magni, eds.) Research Signpost p. 137-168 (2006)
  • Allende, Maria L., Sasaki, Teiji, Kawai, Hiromichi, Olivera, Ana, Mi Yide, van Echten-Deckert, Gerhild, Hajdu Richard, Rosenbach Mark, Keohane Carol Ann, Mandala, Suzanne, Spiegel, Sarah, Proia, Richard L. Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720. J. Biol. Chem. 279, 52487-52492 (2004)
  • Triola, G, Fabrias, G, Dragusin, M, Niederhausen, L, Broere, R, Llebaria, A, van Echten-Deckert, G. Specificity of the dihydroceramide desaturase inhibitor N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide (GT11) in primary cultured cerebellar neurons. Mol Pharmacol. 66, 1671-1678 (2004)
  • Buccoliero, Rosaria, Bodennec Jaques, van Echten-Deckert, Gerhild, Sandhoff, Konrad, Futerman, Anthony H. Phospholipid synthesis is specifically decreased in neuronal tissues in a mouse model of Sandhoff disease. J. Neurochem. 90, 80-88 (2004)
  • Dragusin, Mihaela, Gurgui, Cristian, Schwarzmann, Günter, Hoernschemeyer, Joerg and van Echten-Deckert, Gerhild. Metabolism of the unnatural anticancer lipid safingol (L-threo-dihydrosphingosine) in cultured cells. J. Lipid Res. 44, 1772-1779 (2003)
  • Semac, Isabelle, Palomba, Carmen, Kulangara, Karina, Klages Natacha, van Echten-Deckert, Gerhild, Borisch, Bettina, Hoessli, Daniel C. Anti-CD20 therapeutic antibody rituximab modifies the functional organization of rafts/microdomains of B lymphoma cells. Cancer Res. 63, 534-540 (2003)
  • Betz, Raymund, Sandhoff , Konrad, Fischer, Klaus-Dieter, van Echten-Deckert, Gerhild. Detection and identification of Vav1 protein in primary cultured murine cerebellar neurons and in neuroblastoma cells (SH-SY5Y and Neuro-2a). Neurosci. Lett. 13, 37-40 (2003)
  • Pelled, Dori, Riebeling, Christian, van Echten-Deckert, Gerhild, Sandhoff, Konrad, Futerman, H. Anthony. Reduced rates of axonal and dendritic growth in embryonic hippocampal neurons cultured from a mouse model of Sandhoff disease. Neuropathol. and Appld. Neurobiol. 29, 341-349 (2003)
  • Elsen, Lutz, Betz, Raymund, Schwarzmann, Günter, Sandhoff, Konrad, van Echten-Deckert, Gerhild. Identification of ceramide binding proteins in neuronal cells.        Neurochem. Res.  27, 717-727 (2002)
  • Nätzker, Sven, Heinemann, Thomas, Figueroa-Perez1, Santiago, Schnieders, Barbara, Schmidt, R. Richard, Sandhoff, Konrad, van Echten-Deckert, Gerhild. cis-4-Methylsphingosine-phosphate induces apoptosis in neuroblastoma cells by opposite effects on p38 and ERK MAPKs. Biol. Chem. 383, 1885-1894 (2002)
  • van Echten-Deckert, Gerhild, Nätzger, Sven. The role of sphingolipids in cell signaling. Studies with synthetic analogues. Proc. Internatl. Convention of the Pharm. Soc. Korea 2, 102-108 (2001)
  • Sadeghlar, Farsaneh, Sandhoff, Konrad, van Echten-Deckert, Gerhild. Cell type specific localization of sphingomyelin biosynthesis. FEBS. Lett. 478, 9-12 (2000)
  • Herget, T, Esdar, C, Oehrlein , SA., Heinrich, M, Schütze, S, Maelicke, A, van Echten-Deckert, G. Production of ceramides causes apoptosis during early neural differentiation in vitro. J. Biol. Chem. 275, 30344-30354 (2000)
  • Schulze, Heike, Michel, Christoph, van Echten-Deckert, Gerhild. Dihydroceramide desaturase. In: Methods in Enzymology (Y.A. Hannun, A.H. Merrill, eds.) Academic Press San Diego, Vol. 311, p. 22-30 (2000)
  • van Echten-Deckert, Gerhild. Steuerung der Sphingolipid-Biosynthese. Signalfunktion von Sphingolipid-Metaboliten. Biospektrum 3, 194-195 (2000)
  • van Echten-Deckert, Gerhild. Sphingolipid extraction, and analysis by thin-layer chromatography. In: Methods in Enzymology (Y.A. Hannun, A.H. Merrill, eds.) Academic Press San Diego, Vol. 312, p. 64-79 (2000)
  • Ilangumaran, Subburaj, Arni, Stephan, van Echten-Deckert, Gerhild, Borisch, Bettina, Hoessli, Daniel, C. Microdomain-dependent regulation of Lck and Fyn protein-tyrosine kinases in T lymphocyte plasma membranes. Mol. Biol. Cell 10, 891-905 (1999)
  • van Echten-Deckert, Gerhild, Sandhoff, Konrad. Organization and topology of sphingolipid metabolism. In: Comprehensive Natural Products Chemistry (B.M. Pinto, ed.) Elsevier Science Amsterdam-Oxford, Vol. 3, p.87-106 (1999)
  • van Echten-Deckert, Gerhild, Schick, Andreas, Heinemann, Thomas, Schnieders, Barbara. Phosphorylated cis-4-methylsphingosine mimics the mitogenic effect of sphingosine-1-phosphate in Swiss 3T3 fibroblasts. J. Biol. Chem. 273, 23585-23589 (1998)
  • van Echten-Deckert, Gerhild, Giannis, Athanassios, Schwarz, Andreas, Futerman, Anthony, H., Sandhoff, Konrad. 1-Methylthiodihydroceramide, a novel analog of dihydroceramide, stimulates sphinganine degradation resulting in a decreased de novo sphingolipid biosynthesis. J. Biol. Chem. 273, 1184-1191 (1998)
  • Sandhoff, Konrad, Kolter, Thomas, van Echten-Deckert, Gerhild. Sphingolipid metabolism: Sphingoid analogs, sphingolipid activator proteins and the pathology of the cell. Annals New York Acad. Sci. 845, 139-151 (1998)
  • Michel, Christoph, van Echten-Deckert, Gerhild. Conversion of dihydroceramide to ceramide occurs at the cytosolic face of the endoplasmic reticulum. FEBS Lett. 416, 153-155 (1997)
  • van Echten-Deckert, Gerhild, Klein, Andreas, Linke, Thomas, Heinemann, Thomas, Weisgerber, Judith, Sandhoff, Konrad. Turnover of endogenous ceramide in cultured normal and Farber fibroblasts. J. Lipid Res. 38, 2569-2579 (1997b)
  • Michel, Christoph, van Echten-Deckert, Gerhild, Rother, Jürgen, Sandhoff, Konrad, Wang, Elaine, Merrill, Alfred, H., Jr. Characterization of ceramide synthesis: A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide. J. Biol. Chem. 272, 22432-22437 (1997)
  • van Echten-Deckert, Gerhild, Zschoche, Alexandra, Bär, Thomas, Schmidt, R. Richard, Raths, Andrea, Heinemann, Thomas, Sandhoff, Konrad. cis-4-Methylsphingosine decreases sphingolipid biosynthesis by specifically interfering with serine palmitoyltransferase activity in primary cultured neurons. J. Biol. Chem. 272, 15825-15833 (1997a)
  • Hirschberg, Koret, Zisling, Rivka, van Echten-Deckert, Gerhild, Futermann, Anthony H. Ganglioside synthesis during the development of neuronal polarity. J. Biol. Chem. 271, 14876-14882 (1996)
  • Arni, Stephan, Ilangumaran, Subburaj, van Echten-Deckert, Gerhild, Sandhoff, Konrad, Poincelet, Monique, Briol, Anne, Runager-Brändle, Elisabeth and Hoessli, Daniel, C. Differential regulation of Src-family protein tyrosine kinases in GPI domains of T lymphocyte plasma membranes. Biochem. Biophys. Res. Commun. 225, 801-807 (1996)
  • Zacharias, Claudia, van Echten-Deckert, Gerhild, Wang, Elaine, Merrill, Alfred, H., Jr., and Sandhoff, Konrad. The effect of fumonisin B1 on developing chick embryos: Correlation between de novo sphingolipid biosynthesis and gross morphological changes. Glycoconjugate J. 13, 167-175 (1996)
  • Suzuki, Kunihiko, van Echten-Deckert, Gerhild, Klein, Andreas, Sandhoff, Konrad. Glycosphingolipids and sphingolipid activator proteins: Cell biology, biochemistry and molecular genetics. In: Biochemistry of Cell Membranes. A compendium of selected topics (Papa, S., Tager, J.M. eds.), Birkhäuser Verlag, 137-149 (1995)
  • Sandhoff, Konrad, van Echten-Deckert, Gerhild. Glycolipids of cellular surfaces: Topology of metabolism, function and pathobiochemistry of glycolipid binding proteins. In: Trafficking of Intracellular Membranes: From molecular sorting to membrane fusion (Pedroso de Lima, M. C., Düzgünes, N., Hoekstra, D. eds.), Springer Verlag, NATO ASI Series, Vol. H 91, p. 235-246 (1995)
  • Kolter, Thomas, van Echten-Deckert Gerhild, Sandhoff, Konrad. Synthesis of sphinganine analogues modified in the head group. Tetrahedron 50, 13425-13432 (1994)
  • Zacharias, Claudia, van Echten-Deckert, Gerhild, Plewe, Michael, Schmidt, R. Richard, Sandhoff, Konrad. A truncated epoxy-glucosylceramide uncouples glycosphingolipid biosynthesis by decreasing lactosylceramide synthase activity. J. Biol. Chem. 269, 13313-13317 (1994)
  • Sandhoff, Konrad, van Echten, Gerhild. Topology and regulation of ganglioside metabolism - Function and pathobiochemistry of sphingolipid activator proteins. In: Glyco- and Cell biology - 44. Colloquium Mosbach - (Wieland, F., Reutter, W. eds.), Springer Verlag, 69 –79 (1994)
  • Sandhoff, Konrad, van Echten, Gerhild. Metabolism of gangliosides - Topology, pathobiochemistry and sphingolipid activator proteins. In Current Topics in Membranes (Hoekstra, D. ed.), Academic Press, Chapter 3, Vol. 40, p. 75-91 (1994)
  • Sandhoff, Konrad, van Echten, Gerhild. Ganglioside metabolism: Enzymology, topology and regulation. In: Progress in Brain Research (L. Svennerholm, A.K. Ashbury, R.A. Reisfeld, K. Sandhoff, K. Suzuki, G. Tettamanti, G. Toffano, eds.), Elsevier Science B.V., Chapter 2, Vol. 101, p. 17-29 (1994)
  • Merrill, Alfred, H. Jr., van Echten, Gerhild, Wang, Elaine, Sandhoff, Konrad. Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. J. Biol. Chem. 268, 27299-27306 (1993)
  • Klima, Horst, Klein, Andreas, van Echten, Gerhild, Schwarzmann, Günter, Suzuki, Kunihiko, Sandhoff, Konrad. Over-expression of a functionally active human GM2-activator protein in Escherichia coli. Biochem. J. 292, 571-576 (1993)
  • van Echten, Gerhild, Sandhoff, Konrad. Ganglioside Metabolism. Enzymology, topology and regulation. J. Biol. Chem. 268, 5341-5344 (1993)
  • Sandhoff, Konrad, van Echten, Gerhild. Ganglioside metabolism - Topology and regulation. In: Advances in Lipid Research (Bell, R.M., Hannun, Y.A., Merrill, A.H.Jr. eds.) Academic Press, Vol. 26, p. 119-142 (1993)
  • Rother, Jürgen, van Echten, Gerhild, Schwarzmann, Günter, Sandhoff, Konrad. Biosynthesis of sphingolipids: Dihydroceramide and not sphinganine is desaturated by cultured cells. Biochem. Biophys. Res. Commun. 189, 14-20 (1992)
  • Mandon, C. Elisabet, Ehses, Ingrid, Rother, Jürgen, van Echten, Gerhild, Sandhoff, Konrad.  Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver. J. Biol. Chem. 267, 11144-11148 (1992)
  • Iber, Heinrich, van Echten, Gerhild, Sandhoff, Konrad. Fractionation of primary cultured neurons: Distribution of sialyltransferases involved in ganglioside biosynthesis. J. Neurochem., 58, 1533-1537 (1992)
  • Sandhoff, Konrad, van Echten, Gerhild, Schröder, Maria, Schnabel, Doris, Suzuki, Kunihiko. Metabolism of glycolipids. The role of glycolipid-binding proteins in the function and pathobiochemistry of lysosomes. Biochem. Soc. Trans. 20, 695-699 (1992)
  • Mandon, C. Elisabet, van Echten, Gerhild, Birk, Rolf, Schmidt, R. Richard,  Sandhoff, Konrad. Sphingolipid biosynthesis in cultured neurons - Down-regulation of serine palmitoyltransferase by sphingoid bases. Eur. J. Biochem.198, 667-674 (1991)
  • Iber, Heinrich, van Echten, Gerhild, Sandhoff, Konrad. Substrate specificity of 2->3 sialyltransferases in ganglioside biosynthesis of rat liver Golgi. Eur. J. Biochem. 195, 115-120 (1991)
  • Iber, Heinrich, van Echten, Gerhild, Klein, A. Roger, Sandhoff, Konrad. pH-Dependent changes of ganglioside biosynthesis in neuronal cell culture. Eur. J. Cell Biol. 52, 236-240 (1990)
  • van Echten, Gerhild, Birk, Rolf, Brenner-Weiß, Gerald, Schmidt, R. Richard, Sandhoff, Konrad. Modulation of sphingolipid biosynthesis in primary cultured neurons by long chain bases. J. Biol. Chem. 265, 9333-9339 (1990b)
  • van Echten, Gerhild, Iber, Heinrich, Stotz, Harald, Takatsuki, Akira, Sandhoff, Konrad. Uncoupling of ganglioside biosynthesis by Brefeldin A. Eur. J. Cell Biol. 51, 135-139 (1990a)
  • van Echten, Gerhild, Sandhoff, Konrad. Modulation of ganglioside biosynthesis in primary cultured neurons. J. Neurochem. 52, 207-214 (1989)
  • van Echten, Gerhild, Eckel, Jürgen, Reinauer, Hans. Down-regulation of insulin receptors in the heart: Studies on primary cultured adult cardiac myocytes. Biochim. Biophys. Acta 886, 468-473 (1986)
  • Eckel, Jürgen, van Echten, Gerhild, Reinauer, Hans. Adult cardiac myocytes in culture: Cell characteristics and insulin-receptor interaction. Am. J. Physiol. 249, H212-H221 (1985)
  • Mester, Radu, Scripcariu, Dragos, Hutter, Gerhild. NAD kinase from Saccharomyces carlsbergensis. Purification and characterization. Rev. Roum. Biochim. 17, 4, 263-271 (1980)

Patente

  • Tolba, R., van Echten-Deckert G., Lentzen, G., Bilstein, A. Verwendung von Tetrahydropyrimidinen, 09706015.6 – 2123  PCT/EP2009000641 (2010).