Publikationen

Publikationen 2018 bis heute

Marie Paradis, Nicole Kucharowski, Gabriela Edwards Faret, Santiago José Maya Palacios,Christian Meyer, Birgit Stümpges, Isabell Jamitzky, Julia Kalinowski, Christoph Thiele, Reinhard Bauer, Achim Paululat, Julia Sellin, Margret H. Bülow. The ER protein Creld regulates ER-mitochondria contact dynamics and respiratory complex 1 activity.
doi: 10.21203/rs.3.rs-911428/v1

Ben D. McNally, Dean F. Ashley, Lea Hänschke, Hélène N. Daou, Nicole T. Watt, Steven A. Murfitt, Amanda D. V. MacCannell, Anna Whitehead, T. Scott Bowen, Francis W. B. Sanders, Michele Vacca, Klaus K. Witte, Graeme R. Davies, Reinhard Bauer, Julian L. Griffin & Lee D. Roberts. Long-chain ceramides are cell non-autonomous signals linking lipotoxicity to endoplasmic reticulum stress in skeletal muscle. Nat Commun. 2022 Apr 1;13(1):1748.
doi: 10.1038/s41467-022-29363-9.

De Filippis C, Napoli B, Rigon L, Guarato G, Bauer R, Tomanin R, Orso G. Drosophila D-idua Reduction Mimics Mucopolysaccharidosis Type I Disease-Related Phenotypes. Cells. 2021 Dec 31;11(1):129.
doi: 10.3390/cells11010129.

Paul Kern, Nora R. Balzer, Nelli Blank, Cornelia Cygon, Klaus Wunderling, Franziska Bender, Alex Frolov, Jan-Peter Sowa, Lorenzo Bonaguro, Thomas Ulas, Mirka Homrich, Eva Kiermaier, Christoph Thiele, Joachim L. Schultze, Ali Canbay, Reinhard Bauer, Elvira Mass. Creld2 function during unfolded protein response is essential for liver metabolism homeostasis. FASEB J, 2021 Oct;35(10):e21939.
doi: 10.1096/fj.202002713RR.

Rigon L, Kucharowski N, Eckardt F, Bauer R. Modeling Mucopolysaccharidosis Type II in the Fruit Fly by Using the RNA Interference Approach. Life (Basel). 2020 Oct 30;10(11):263.
doi: 10.3390/life10110263.

Sellin J, Fülle JB, Thiele C, Bauer R, Bülow MH. Free fatty acid determination as a tool for modeling metabolic diseases in Drosophila. J Insect Physiol. 2020 Oct;126:104090 Epub 2020 Jul 28.
doi: 10.1016/j.jinsphys.2020.104090

Sociale M, Wulf AL, Breiden B, Klee K, Thielisch M, Eckardt F, Sellin J, Bülow MH, Löbbert S, Weinstock N, Voelzmann A, Schultze J, Sandhoff K, Bauer R. Ceramide Synthase Schlank Is a Transcriptional Regulator Adapting Gene Expression to Energy Requirements. Cell Rep., 22, 967-978, (2018). 
doi: 10.1016/j.celrep.2017.12.090

Bülow MH, Wingen C, Senyilmaz D, Gosejacob D, Sociale M, Bauer R, Schulze H, Sandhoff K, Teleman AA, Hoch M, Sellin J. Unbalanced lipolysis results in lipotoxicity and mitochondrial damage in peroxisome-deficient Pex19 mutants. Mol Biol Cell, 29, 396-407, (2018). 
doi: 10.1091/mbc.E17-08-0535

Bickert A, Kern P, van Uelft M, Herresthal S, Ulas T, Gutbrod K, Breiden B, Degen J, Sandhoff K, Schultze JL, Dörmann P, Hartmann D, Bauer R, Willecke K. Inactivation of ceramide synthase 2 catalytic activity in mice affects transcription of genes involved in lipid metabolism and cell division. Biochim Biophys Acta Mol Cell Biol Lipids. 1863,734-749, (2018). 
doi: 10.1016/j.bbalip.2018.04.006

Publikationen 2016 und 2017

Aschenbrenner AC, Bassler K, Brondolin M, Bonaguro L, Carrera P, Klee K, Ulas T, Schultze JL, Hoch M. A cross-species approach to identify transcriptional regulators exemplified for Dnajc22 and Hnf4a. Sci Rep. 2017 Jun 22;7(1):4056.

Loch G, Zinke I, Mori T, Carrera P, Schroer J, Takeyama H, Hoch M. Antimicrobial peptides extend lifespan in Drosophila. PLoS One. 2017 May 17;12(5):e0176689.

Richard M, Bauer R, Tavosanis G, Hoch M. The gap junction protein Innexin3 is required for eye disc growth in Drosophila. Dev Biol. 2017 May 15;425(2):191-207.

Sellin J, Schulze H, Paradis M, Gosejacob D, Papan C, Shevchenko A, Psathaki OE, Paululat A, Thielisch M, Sandhoff K, Hoch M. Characterization of Drosophila Saposin-related mutants as a model for lysosomal sphingolipid storage diseases. Dis Model Mech. 2017 Jun 1;10(6):737-750.

Wakabayashi S, Sawamura N, Voelzmann A, Broemer M, Asahi T, Hoch M. Ohgata, the Single Drosophila Ortholog of Human Cereblon, Regulates Insulin Signaling-dependent Organismic Growth. J Biol Chem. 2016 Nov 25;291(48):25120-25132. Epub 2016 Oct 4.

Voelzmann A, Wulf AL, Eckardt F, Thielisch M, Brondolin M, Pesch YY, Sociale M, Bauer R, Hoch M. Nuclear Drosophila CerS Schlank regulates lipid homeostasis via the homeodomain, independent of the lag1p motif. FEBS Lett. 2016 Apr;590(7):971-81. doi: 10.1002/1873-3468.12125. Epub 2016 Mar 28.

Gosejacob D, Jäger PS, Vom Dorp K, Frejno M, Carstensen AC, Köhnke M, Degen J, Dörmann P, Hoch M. Ceramide Synthase 5 Is Essential to Maintain C16:0-Ceramide Pools and Contributes to the Development of Diet-induced Obesity. J Biol Chem. 2016 Mar 25;291(13):6989-7003. doi: 10.1074/jbc.M115.691212. Epub 2016 Feb 7.

Weitere ausgewählte Publikationen

Mass E, Wachten D, Aschenbrenner AC, Voelzmann A and Hoch M. (2014). Murine Creld1 Controls Cardiac Development through Activation of Calcineurin/NFATc1 Signaling. Dev Cell 2014; 28(6): 711-726.

Becker T, Loch G, Beyer M, Zinke I, Aschenbrenner AC, Carrera P, Inhester T, Schultze JL, Hoch M. FOXO-dependent regulation of innate immune homeostasis. Nature 2010; 463: 369-373.

Bauer R, Voelzmann A, Breiden B, Schepers U, Farwanah H, Hahn I, Eckardt F, Sandhoff K, Hoch M. Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila. EMBO J 2009; 28: 3706-3716.

Behr M, Wingen C, Wolf C, Schuh R, Hoch M. Wurst is essential for airway clearance and respiratory-tube size control. Nat Cell Biol 2007; 9: 847-853. 

Fuss B, Becker T, Zinke I, Hoch M. The cytohesin Steppke is essential for insulin signalling in Drosophila. Nature 2006; 444: 945-948.