Ältere Publikationen

2005

  • Jäger, S., Rasched, G., Kornreich-Leshem, H., Engesser, M., Thum, O., and Famulok, M.
    A versatile toolbox for variable DNA functionalisation at high density.
    J. Am. Chem. Soc. 2005, 127, 15071-15082. [PDF]
    • Highlight on Jäger et al. by Eisenstein, M.
      Chemical Biology: Decking out your DNA
      Nature Methods 2005, 2, 896. [PDF]
       
  • Najafi-Shoushtari, H., and Famulok, M.
    Competitive regulation of modular allosteric aptazymes by a small molecule and oligonucleotide effector.
    RNA 2005, 11, 1514-1520. [PDF] - [Supplementary material]
     
  • Joseph, S., Gronewold, T. M., Schlensog, M. D., Olbrich, C., Quandt, E., Famulok, M., and Schirner, M.
    Specific targeting of ultrasound contrast agent (USCA) for diagnostic application: an in vitro feasibility study based on SAW biosensor.
    Biosens. Bioelectron. 2005, 2, 1829-1835. [PDF]
     
  • Fusz, S., Eisenführ, A., Srivatsan, S. G., Heckel, A., and Famulok, M.
    A ribozyme for the aldol reaction.
    Chem. Biol. 2005, 12, 941-950. [PDF]
    • News and Views on Fusz et al. by Yarus, M.
      Chemical Biology: Bring them back alive.
      Nature 2005, 438, 40. [PDF]
    • News coverage on Fusz et al. by Anheuser, M.
      Am Anfang allen Lebens - Was war zuerst da: Eiweiß, DNS oder RNS?
      Süddeutsche Zeitung, 29.09.2005, Wissen
      Weitze, M.-D.
      Per Evolution zu neuen Katalysatoren
        Neue Zürcher Zeitung 23.11.2005, Forschung und Technik
         
    • Wahle, T., Prager, K., Raffler, N., Haass, C., Famulok, M., and Walter, J.
      CGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network.
      Mol. Cell Neurosci. 2005, 29, 453-461. [PDF]
       
    • Gronewold, T. M. A., Glass, S., Quandt, E., and Famulok, M.
      Monitoring complex formation in the blood coagulation cascade using aptamer-coated SAW sensors.
      BioSens. Bioelectron. 2005, 20, 2044-2052. [PDF]

    2004

    • Najafi-Shoushtari, S. H., Mayer, G., and Famulok, M.
      Sensing complex regulatory networks by conformationally controlled hairpin ribozymes.
      Nucleic Acids Res. 2004, 29, 3212-3219. [PDF]

    • Theis, M., Knorre, A., Kellersch, B., Moelleken, J., Wieland, F., Kolanus, W., and Famulok, M.
      Discriminatory aptamer reveals serum response element transcription regulated by cytohesin 2.
      Proc. Natl. Acad. Sci. 2004, 101, 11221-11226. [PDF]

    • Jäger, S., and Famulok, M.
      Generation and amplification of DNA functionalized at ultra-high density.
      Angew. Chem. Int. Ed. 2004, 43, 3337-3340. [PDF]

    • Schlensog, M. D., Gronewold, T. M. A., Tewes, M., Famulok, M., and Quandt, E.
      A Love-wave biosensor using nucleic acids as ligands.
      Sens. Actuat. 2004, 101, 308-315. [PDF]

    • Hartig, J. S., Grüne, I., Najafi-Shoushtari, S. H., and Famulok, M.
      Sequence-specific detection of microRNAs by signal-amplifying ribozymes.
      J. Am. Chem. Soc. 2004, 126, 722-723. [PDF]

    2003

    • Betat, H., Vogel, S., Struhalla, M., Förster, H.-H., Famulok, M., Welzel, P., and Hahn, U.
      Aptamers that recognize the lipid moiety of the antibiotic Moenomycin A.
      Biol. Chem.2003, 384, 1497-1500. [PDF]

    • Raffler, N. A., Schneider-Mergener, J., and Famulok, M.
      A novel class of small functional peptides that bind and inhibit human α-thrombin isolated by mRNA display.
      Chem. Biol. 2003, 10, 69-79. [PDF]

    • Eisenführ, A., Arora, P. S., Sengle, G., Takaoka, L. R., Nowick, J. S., and Famulok, M.
      A Ribozyme with Michaelase activity: Synthesis of the substrate precursors.
      Bioorg. Med. Chem. 2003, 11, 235-249. [PDF]

    2002

    • Hartig, J. S., and Famulok, M.
      Reporter ribozymes for real-time analysis of domain-specific interactions in biomolecules: HIV-1 reverse transcriptase and the primer-template complex.
      Angew. Chem. Int. Ed. 2002, 41, 4263-4266. [PDF]

    • Proske, D., Gilch, S., Wopfner, F., Schätzl, H. M., Winnacker, E.-L., and Famulok, M.
      Prion-protein-specific aptamer reduces PrPSc formation.
      ChemBioChem 2002, 3, 717-725. [PDF]

    • Hartig, J. S., Najafi-Shoushtari, S. H., Grüne, I., Yan, A., Ellington, A. D., and Famulok, M.
      Protein-dependent ribozymes report molecular interactions in real time.
      Nat. Biotechnol. 2002, 20, 717-722. [PDF]

    • Proske, D., Höfliger, M., Söll, R. M., Beck-Sickinger, A. G., and Famulok, M.
      A Y2 receptor mimetic aptamer directed against neuropeptide Y.
      J. Biol. Chem. 2002, 277, 11416-11422. [PDF]

    2001

    • Thum, O., Jäger, S., and Famulok, M.
      Functionalized DNA: A new replicable biopolymer.
      Angew. Chem. Int. Ed. 2001, 40, 3990-3993. [PDF]

    • Piganeau, N., Thuillier, V., and Famulok, M.
      In vitro selection of allosteric ribozymes: Theory and experimental validation.
      J. Mol. Biol. 2001, 312, 885-898. [PDF]

    • Schürer, H., Stembera, K., Knoll, D., Mayer, G., Blind, M., Förster, H., Famulok, M., Welzel, P., and Hahn, U.
      Aptamers that bind to the antibiotic Moenomycin A.
      Bioorg. Med. Chem. 2001, 9, 2557-2563. [PDF]

    • Sengle, G., Eisenführ, A., Arora, P. S., Nowick, J. S., and Famulok, M.
      Novel RNA catalysts for the Michael reaction.
      Chem. Biol. 2001, 8, 459-473. [PDF]

    • Mayer, G., Blind, M., Nagel, W., Böhm, T., Knorr, T., Jackson, C. L., Kolanus, W., and Famulok, M.
      Controlling small guanine–nucleotide-exchange factor function through cytoplasmic RNA intramers.
      Proc. Natl. Acad. Sci. USA 2001, 98, 4961-4965. [PDF]

    • Schürer, H., Buchynskyy, A., Korn, K., Famulok, M., Welzel, P., and Hahn, U.
      Fluorescence correlation spectroscopy as a new method for the investigation of aptamer/target interactions.
      Biol. Chem. 2001, 382, 479-481. [PDF]

    • Jenne, A., Hartig, J. S., Piganeau, N., Tauer, A., Samarsky, D. A., Green, M. R., Davies, J., and Famulok, M.
      Rapid identification and characterization of hammerhead-ribozyme inhibitors using fluorescence-based technology.
      Nat. Biotechnol. 2001, 19, 56-61. [PDF]

    2000

    • Piganeau, N., Jenne, A., Thuillier, V., and Famulok, M.
      An allosteric ribozyme regulated by Doxycycline.
      Angew. Chem. Int. Ed. 2000, 39, 4369-4373. [PDF] - [Corrigendum]

    • Sengle, G., Jenne, A., Arora, P. S., Seelig, B., Nowick, J. S., Jäschke, A., and Famulok, M.
      Synthesis, incorporation efficiency, and stability of disulfide bridged functional groups at RNA 5'-ends.
      Bioorg. Med. Chem. 2000, 8, 1317-1329. [PDF]