Molekulare Immunologie und Zellbiologie
Prof. Dr. rer. nat. Waldemar Kolanus
Ausgewählte Publikationen
Thomas Quast, Karolin Zölzer, Donald Guu, Luis Alvarez, Carsten Küsters, Eva Kiermaier, U Benjamin Kaupp, Waldemar Kolanus. A Stable Chemokine Gradient Controls Directional Persistence of Migrating Dentritic Cells. Front Cell Dev Biol. 2022 Aug 9;10:943041. Doi: 10.3389/fcell.2022.943041. eCollection 2022
Phan Q Duy, Stefan C Weise,…Lucia A Torres-Fernández,…Bettina Jux,…Waldemar Kolanus, Kristopher T Kahle. Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus. Nat Neurosci. 2022 Apr;25(4):458-473. Doi:10.1038/s41593-022-01043-3
- Rafeld HL, Kolanus W, van Driel IR, Hartland EL. Interferon-induced GTPases
orchestrate host cell-autonomous defence against
bacterial pathogens. Biochem Soc Trans. 2021 May 18:BST20200900. doi:
10.1042/BST20200900. Online ahead of print.
PMID: 34003245 - Torres Fernández LA, Mitschka S, Ulas T, Weise S, Dahm K, Becker M, Händler
K, Beyer M, Windhausen J, Schultze JL, Kolanus
W. The stem cell-specific protein TRIM71 inhibits maturation and activity of
the pro-differentiation miRNA let-7 via two
independent molecular mechanisms. RNA. 2021 May 11:rna.078696.121. doi:
10.1261/rna.078696.121. Online ahead of
print. PMID: 33975917 - Torres-Fernández LA, Emich J, Port Y, Mitschka S, Wöste M, Schneider S,
Fietz D, Oud MS, Di Persio S, Neuhaus N, Kliesch S,
Hölzel M, Schorle H, Friedrich C, Tüttelmann F, Kolanus W. TRIM71 Deficiency
Causes Germ Cell Loss During Mouse Embryogenesis
and Is Associated With Human Male Infertility. Front Cell Dev Biol. 2021 May
13;9:658966. doi: 10.3389/
fcell.2021.658966. eCollection 2021. PMID: 34055789 - Torres-Fernández L A, Jux B, Bille M, Port Y, Schneider K, Geyer M, Mayer G, and W Kolanus.
The mRNA repressor TRIM71 cooperates with Nonsense-Mediated Decay factors to destabilize the mRNA of CDKN1A/p21.
Nucleic Acids Research 2019, 47, doi.org/10.1093/nar/gkz1057 - Jux B, Gosejacob D, Tolksdorf F, Mandel C, Rieck M, Namislo A, Pfeifer A, Kolanus W.
Cytohesin-3 is required for full insulin receptor signaling and controls body weight via lipid excretion.
Sci Rep. 2019 Mar 5;9(1):3442. doi: 10.1038/s41598-019-40231-3. - Tolksdorf F, Mikulec J, Geers B, Endig J, Sprezyna P, Heukamp LC, Knolle PA, Kolanus W, Diehl L.
The PDL1-inducible GTPase Arl4d controls T effector function by limiting IL-2 production.
Sci Rep. 2018 Oct 31;8(1):16123. doi: 10.1038/s41598-018-34522-4. - Yu CF, Peng WM, Schlee M, Barchet W, Eis-Hübinger AM, Kolanus W, Geyer M, Schmitt S, Steinhagen F, Oldenburg J, Novak N.
SOCS1 and SOCS3 Target IRF7 Degradation To Suppress TLR7-Mediated Type I IFN Production of Human Plasmacytoid Dendritic Cells.
J Immunol. 2018 Jun 15;200(12):4024-4035. doi: 10.4049/jimmunol.1700510. Epub 2018 Apr 30. - Chishti AA, Baumstark-Khan C, Koch K, Kolanus W, Feles S, Konda B, Azhar A, Spitta LF, Henschenmacher B, Diegeler S, Schmitz C, Hellweg CE.
Linear Energy Transfer Modulates Radiation-Induced NF-kappa B Activation and Expression of its Downstream Target Genes.
Radiat Res. 2018 Apr;189(4):354-370. doi: 10.1667/RR14905.1. Epub 2018 Jan 25. - Sander J, Schmidt SV, Cirovic B, McGovern N, Papantonopoulou O, Hardt AL, Aschenbrenner AC, Kreer C, Quast T, Xu AM, Schmidleithner LM, Theis H, Thi Huong LD, Sumatoh HRB, Lauterbach MAR, Schulte-Schrepping J, Günther P, Xue J, Baßler K, Ulas T, Klee K, Katzmarski N, Herresthal S, Krebs W, Martin B, Latz E, Händler K, Kraut M, Kolanus W, Beyer M, Falk CS, Wiegmann B, Burgdorf S, Melosh NA, Newell EW, Ginhoux F, Schlitzer A, Schultze JL.
Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2.
Immunity. 2017 Dec 19;47(6):1051-1066.e12. doi: 10.1016/j.immuni.2017.11.024 - Layer JP, Kronmüller MT, Quast T, van den Boorn-Konijnenberg D, Effern M, Hinze D, Althoff K, Schramm A, Westermann F, Peifer M, Hartmann G, Tüting T, Kolanus W, Fischer M, Schulte J, Hölzel M.
Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression.
Oncoimmunology. 2017 Apr 28;6(6):e1320626. doi: 10.1080/2162402X.2017.1320626. eCollection 2017. - Reinhardt J, Landsberg J, Schmid-Burgk JL, Ramis BB, Bald T, Glodde N, Lopez-Ramos D, Young A, Ngiow SF, Nettersheim D, Schorle H, Quast T, Kolanus W, Schadendorf D, Long GV, Madore J, Scolyer RA, Ribas A, Smyth MJ, Tumeh PC, Tüting T, Hölzel M.
MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy.
Cancer Res. 2017 Sep 1;77(17):4697-4709. doi: 10.1158/0008-5472.CAN-17-0395. Epub 2017 Jun 26. - Eppler FJ, Quast T, Kolanus W.
Dynamin2 controls Rap1 activation and integrin clustering in human T lymphocyte adhesion.
PLoS One. 2017 Mar 8;12(3):e0172443. doi: 10.1371/journal.pone.0172443. eCollection 2017. - Rieck M, Kremser C, Jobin K, Mettke E, Kurts C, Gräler M, Willecke K, Kolanus W.
Ceramide synthase 2 facilitates S1P-dependent egress of thymocytes into the circulation in mice.
Eur J Immunol. 2017 Apr;47(4):677-684. doi: 10.1002/eji.201646623. Epub 2017 Feb 27. - Bald T, Quast T, Landsberg J, Rogava M, Glodde N, Lopez-Ramos D, Kohlmeyer J, Riesenberg S, van den Boorn-Konijnenberg D, Hömig-Hölzel C, Reuten R, Schadow B, Weighardt H, Wenzel D, Helfrich I, Schadendorf D, Bloch W, Bianchi ME, Lugassy C, Barnhill RL, Koch M, Fleischmann BK, Förster I, Kastenmüller W, Kolanus W, Hölzel M, Gaffal E, Tüting T (2014).
Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma.
Nature. 2014 Feb 26. doi: 10.1038/nature13111. - Schiwon M, Weisheit C, Franken L, Gutweiler S, Dixit A, Meyer-Schwesinger C, Pohl JM, Maurice NJ, Thiebes S, Lorenz K, Quast T, Fuhrmann M, Baumgarten G, Lohse MJ, Opdenakker G, Bernhagen J, Bucala R, Panzer U, Kolanus W, Gröne HJ, Garbi N, Kastenmüller W, Knolle PA, Kurts C, Engel DR (2014).
Crosstalk between Sentinel and Helper Macrophages Permits Neutrophil Migration into Infected Uroepithelium.
Cell. 2014 Jan 30;156(3):456-68. doi: 10.1016/j.cell.2014.01.006. - Müller S, Quast T, Schröder A, Hucke S, Klotz L, Jantsch J, Gerzer R, Hemmersbach R, Kolanus W. (2013).
Salt-Dependent Chemotaxis of Macrophages.
PLoS One. 8, e73439 - Müller R, Herr C, Sukumaran SK, Omosigho NN, Plomann M, Riyahi TY, Stumpf M, Swaminathan K, Tsangarides M, Yiannakou K, Blau-Wasser R, Gallinger C, Schleicher M, Kolanus W, Noegel AA. (2013).
The cytohesin paralog Sec7 of Dictyostelium discoideum is required for phagocytosis and cell motility.
Cell Commun Signal.11, doi: 10.1186/1478-811X-11-54. - Ulbricht A, Eppler FJ, Tapia VE, van der Ven PF, Hampe N, Hersch N, Vakeel P, Stadel D, Haas A, Saftig P, Behrends C, Fürst DO, Volkmer R, Hoffmann B, Kolanus W, Höhfeld J. (2013).
Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy.
Curr Biol. 23, 430-435. - Jux B, Staratschek-Jox A, Penninger JM, Schultze JL, Kolanus W. (2013).
Vav1 regulates MHCII expression in murine resting and activated B cells.
Int Immunol. 25, 307-317. - Goller T, Seibold UK, Kremmer E, Voos W, Kolanus W. (2013).
Atad3 function is essential for early post-implantation development in the mouse.
PLoS One. 8, e54799. - Quast T, Eppler F, Semmling V, Schild C, Homsi Y, Levy S, Lang T, Kurts C, Kolanus W. (2011).
CD81 is essential for the formation of membrane protrusions and regulates Rac1-activation in adhesion-dependent immune cell migration.
Blood. 118, 1818-1827. - Semmling V, Lukacs-Kornek V, Thaiss CA, Quast T, Hochheiser K, Panzer U, Rossjohn J, Perlmutter P, Cao J, Godfrey DI, Savage PB, Knolle PA, Kolanus W, Förster I, Kurts C. (2010).
Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs.
Nat Immunol. 11, 313-320. - Shina MC, Müller R, Blau-Wasser R, Glöckner G, Schleicher M, Eichinger L, Noegel AA, Kolanus W. (2010).
A cytohesin homolog in Dictyostelium amoebae.
PLoS One. 5, e9378. - Quast T, Tappertzhofen B, Schild C, Grell J, Czeloth N, Förster R, Alon R, Fraemohs L, Dreck K, Weber C, Lämmermann T, Sixt M, Kolanus W. (2009).
Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells.
Blood. 113, 5801-5810. - Löer B, Bauer R, Bornheim R, Grell J, Kremmer E, Kolanus W, Hoch M. (2008).
The NHL-domain protein Wech is crucial for the integrin-cytoskeleton link.
Nat Cell Biol. 10, 422-428. - Beyer M, Thabet Y, Müller RU, Sadlon T, Classen S, Lahl K, Basu S, Zhou X, Bailey-Bucktrout SL, Krebs W, Schönfeld EA, Böttcher J, Golovina T, Mayer CT, Hofmann A, Sommer D, Debey-Pascher S, Endl E, Limmer A, Hippen KL, Blazar BR, Balderas R, Quast T, Waha A, Mayer G, Famulok M, Knolle PA, Wickenhauser C, Kolanus W, Schermer B, Bluestone JA, Barry SC, Sparwasser T, Riley JL, Schultze JL. (2011).
Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation.
Nat Immunol. 12, 898-907.